Inflammatory Pseudotumor of the Lung with Rapid Growth

Yano, Yukihiro; Mori, Masahide; Kagami, Shinichi; Fushitani, Kenji; Sugano, Teppei; Namba, Yoshinobu; Yoneda, Takunari; Yokota, Soichiro; Maeda, Hitoshi; Ueda, Kayo

doi:10.2169/internalmedicine.48.2201

Cited by 9 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pulmonary inflammatory pseudotumor is an extremely rare benign condition that is considered to have a variety of etiologies ranging from inflammation to low‐grade neoplasm . It accounts for 0.04% of primary pulmonary and bronchial tumors . Pulmonary inflammatory pseudotumors most commonly present as a single solitary nodule resembling lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Case report of anti‐transcription intermediary factor‐1‐γ/α antibody‐positive dermatomyositis associated with gastric cancer and immunoglobulin G4‐positive pulmonary inflammatory pseudotumor

Ito

Imafuku

Hamaguchi

et al. 2013

The Journal of Dermatology

View full text Add to dashboard Cite

Dermatomyositis is a rare connective tissue disease often associated with internal malignancy and interstitial pneumonitis. Serologically, various auto-antibodies (Ab) are associated with dermatomyositis. Anti-transcription intermediary factor-1-γ/α (TIF-1-γ/α) Ab was recently identified as an auto-Ab and was observed mostly in cancer-associated dermatomyositis. IgG4-related disease is a newly described entity characterized by increased serum IgG4 levels and IgG4-positive plasma cell infiltration with fibrosis in organs such as the pancreas and parotid gland. IgG4-related disease also includes inflammatory pseudotumors in various organs. We report herein a 59-year-old Japanese man who had dermatomyositis complicated with a gastric cancer and an IgG4-related pulmonary inflammatory pseudotumor. He manifested typical classical Gottron's papules on the fingers, V-sign erythema on the chest, flagellate erythema on the back, nail fold bleeding and facial erythema. Serum levels of anti-TIF-1-γ/α Ab were positive as assessed by immunoprecipitation assay. He also had bilateral swelling of the parotid gland, and an excised specimen of the lung showed inflammatory pseudotumor with IgG4-positive plasma cells. As far as we know, this case is the first to report the association of IgG4-related disease and TIF-1-γ/α-positive dermatomyositis. Further accumulation of such cases is required to elucidate the mechanism of this association.

show abstract

Section: Discussionmentioning

confidence: 99%

Case report of anti‐transcription intermediary factor‐1‐γ/α antibody‐positive dermatomyositis associated with gastric cancer and immunoglobulin G4‐positive pulmonary inflammatory pseudotumor

Ito

Imafuku

Hamaguchi

et al. 2013

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Some lower aggressive lung cancers kept stable or got smaller in certain period [5,16,26] , and some benign nodules grew rapidly [27] , so we did not use the pathological results as a reference of real growth in nGGOs. For solid nodules, an increase in measured nodule volume more than 22.3% was regarded as real growth in software calculation [13] .…”

Section: Discussionmentioning

confidence: 99%

Evaluating the growth of pulmonary nodular ground-glass opacity on CT: Comparison of volume rendering and thin slice images

Liang

Liu

et al. 2011

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

View full text Add to dashboard Cite

This study examined the value of volume rendering (VR) interpretation in assessing the growth of pulmonary nodular ground-glass opacity (nGGO). A total of 47 nGGOs (average size, 9.5 mm; range, 5.7-20.6 mm) were observed by CT scanning at different time under identical parameter settings. The growth of nGGO was analyzed by three radiologists by comparing the thin slice (TS) CT images of initial and repeat scans with side-by-side cine mode. One week later synchronized VR images of the two scans were compared by side-by-side cine mode to evaluate the nGGO growth. The nodule growth was rated on a 5-degree scale: notable growth, slight growth, dubious growth, stagnant growth, shrinkage. Growth standard was defined as: Density increase ≥ 30 HU and (or) diameter increase (by 20% in nodules ≥ 10 mm, 30% in nodules of 5-9 mm). Receiver operating characteristic (ROC) was performed. The results showed that 32 nGGOs met the growth criteria (29 nGGOs showed an increase in density; 1 nGGO showed an increase in diameter; 2 nGGOs showed an increase in both diameter and density). Area under ROC curve revealed that the performance with VR interpretation was better than that with TS interpretation (P<0.01, P<0.05 and P<0.05 for observers A, B and C respectively). Consistency between different observers was excellent with both VR interpretation (κ=0.89 for observers A&C, A&B, B&C) and TS interpretation (κ=0.71 for A&B, κ=0.68 for A&C, κ= 0.74 for B&C), but time spending was less with VR interpretation than with TS interpretation (P<0.0001, P<0.0001 and P<0.05 for observers A, B and C, respectively). It was concluded that VR is a useful technique for evaluating the growth of nGGO.

show abstract

“…The natural history is that of a slow-growing mass starting as a focus of organized pneumonia with a tendency for local invasion. However, rare cases of rapid growth have been reported (Yano et al 2009). Extension of the tumor beyond the confines of the lung is common.…”

Section: Benign Tumorsmentioning

confidence: 99%