Inflammatory Pseudotumor of the Spleen

Inflammatory Pseudotumor of the Spleen: Report of a Case

“…IPT of the spleen may present with both clinical signs and symptoms suggestive of a malignant lymphoproliferative process. Ultrasonography may reveal a partially calcified well-defined echogenic mass or hypoechoic discrete lesions, 5,12 as observed in our case. It has been reported that on CT examination following contrast administration, the presence of a central satellite area corresponding to a fibrous plaque is strongly suggestive of an IPT.…”

“…Inflammatory pseudotumor has histological features of a mixed inflammatory cell infiltrate of plasma cells, lymphocytes, and histiocytes in a fibroblastic stroma. 5 The histopathological diagnosis of IPT does not pose any great difficulty. They can occur in a variety of organs, including the liver, spleen, pancreas, gastrointestinal tract, mesentery, bladder, lymph nodes, respiratory tract, lung, meninges, soft tissues, and orbit.…”

“…3,10 Another hypothesis is that these lesions may be due to an intraparenchymatous hemorrhage secondary to trauma or coagulopathy. 5 The third theory is that the main initial event may have been a focal parenchymal necrosis with hemorrhage. 4 The latter is an immunological hypothesis that is suggested as a cause of the disease due to the high content of plasma cells in inflammatory lesions.…”

Inflammatory pseudotumor of the spleen: Report of a case

“…Although inflammatory pseudotumors have been reported in several anatomic locations, 1-8 splenic involvement is extremely rare. Since the first two cases of inflammatory pseudotumor of the spleen were reported by Cotelingam and Jaffe in 1984, 11 24 cases in Japan 12-25 and 42 cases outside Japan 11,14,[26][27][28][29][30][31][32][33][34][35][36][37][38][39] have been reported. The clinical features of these cases, including the present case, are summarized in Table 1.…”

“…Including the present case, 38 (56%) of 67 the reported cases were detected incidentally. 11,[14][15][16][17][19][20][21][22][23][24][26][27][28][31][32][33][34][35] The diagnostic imaging of splenic inflammatory pseudotumor showed different patterns. Ultrasonography showed a low echoic mass in most cases.…”