Inflammatory Pseudotumor of the Temporal Bone: Three Cases and a Review of the Literature

Tian, Huiqin; Liu, Tingting; Tang, Lijun; Chen, Zhibin; Xing, Guangqian

doi:10.1155/2013/480476

Cited by 13 publications

(13 citation statements)

References 25 publications

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“…(See Table 3). One review in 2013 identified only 29 cases 6 . We are only able to speculate as to why our institution has had a high population of patients with the diagnosis of IPT over the past several years despite no objective data to support a long-term, significant increase in diagnosis of IPT within the head and neck or other areas of the body.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Pseudotumor of the Temporal Bone: A Case Series

Ortlip¹,

Drake²,

Raghavan³

et al. 2017

Otology &Amp; Neurotology

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Objective: Inflammatory pseudotumor of the temporal bone is a benign, idiopathic inflammatory process that is locally invasive and a cause of significant morbidity. This study reviews our experience with seven patients and is currently the largest series to date. Study Design: Retrospective review from January 1, 2014 to January 1, 2016. Setting: Single tertiary medical center. Patients: There were five male and two female (n = 7) subjects with a diagnosis of temporal bone inflammatory pseudotumor. The mean age at presentation was 41 years old. The most common presenting symptoms were hearing loss (7/7) and headache (4/7). Four patients demonstrated an inflammatory aural polyp. Two patients experienced facial nerve paralysis. Intervention(s): Seven patients underwent computed tomography and six underwent magnetic resonance imaging. Corticosteroids and antibiotics were the initial treatment of choice. Five patients also underwent surgery. As adjuvant therapy, two patients received Rituximab, one patient received radiation, and one received mycophenolate mofetil. Main Outcome Measure(s): Clinical courses were followed with focus on symptoms, disease recurrence, duration, and treatment. Mean follow-up was 17.8 months. Results: The primary lesions demonstrated T2 hypo-intensity and enhancement as well as diffuse dural thickening on magnetic resonance imaging in five of six patients. Histopathology demonstrated chronic inflammation in the setting of hyalinized fibrosis (7/7). All the patients are currently symptomatically stable. Conclusion: Inflammatory pseudotumor of the temporal bone can cause devastating effects on neurological function and quality of life. Recognition of characteristic imaging and histopathology can expedite appropriate treatment. Patients may require chronic steroid therapy. Adjunctive therapy with radiation and immuno-modulation are currently being explored.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Pseudotumor of the Temporal Bone: A Case Series

Ortlip¹,

Drake²,

Raghavan³

et al. 2017

Otology &Amp; Neurotology

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“…To date, less than 50 cases of IPT involving the temporal bone have been reported (Table 1). 2,5‐32 Therefore, the clinical physiology of IPT in the temporal bone has not been fully understood, and no standard treatment has been established.…”

Section: Introductionmentioning

confidence: 99%

Labyrinthine destruction caused by inflammatory pseudotumor of the temporal bone: A report of three cases and review of the literature

Imamura

Kasuya

Shimanuki

et al. 2021

Laryngoscope Investig Oto

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Background Inflammatory pseudotumors (IPTs) are rare, idiopathic, and inflammatory lesions that are histopathologically benign. Here, we present three cases of labyrinthine destruction caused by an IPT. Methods The first patient was a 74‐year‐old male with a mass lesion extending from the inner ear to the external ear canal. The second patient was a 62‐year‐old female with a foliated polycystic lesion in the petrous bone on the dorsal side of the left internal auditory canal. The third patient was a 68‐year‐old female with a mass extending from the inner ear to the middle ear, destroying the semicircular canal and cochlea. Results In two cases, we performed surgical resection successfully with no recurrence. In the other case, the lesion showed shrinkage after chemotherapy for colorectal cancer incidentally found during the examination process. Conclusion Surgical technique and indication for IPT should be based on the location and function of the lesion. In addition, there is room to consider pharmacotherapy as a treatment option for IPT of the temporal bone. Level of Evidence 4.

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“…Past treatments have included combinations of steroids, surgical resection, radiation, and/or immunomodulators. Treatment with immunomodulators have included cyclophosphamide, mycophenolate mofetil, methotrexate, alpha interferon, azathioprine, and rituximab (1,2,4,(8)(9)(10)(11)(12)(13). Complete resection is preferred; however, tumor location may prevent a safe and tolerable approach (2).…”

Section: Introductionmentioning

confidence: 99%