Inflammatory pseudotumour of the maxilla

Abstract

Inflammatory pseudotumour (IP), also known as inflammatory myofibroblastic tumour (IMT), is a rare lesion of the maxillofacial skeleton and a diagnosis by exclusion. We describe three cases which affected the maxilla, two women and one man of ages 67, 56 and 70 years at presentation. All showed the typical, rather non-specific histopathological features. IgG4-positive plasma cells varied greatly in prominence, and none of the three lesions expressed ALK-1. Both women responded to steroids and radiotherapy, though one also required azathioprine. Despite maxillectomy, radiotherapy, steroids and cyclophosphamide, the man suffered intracranial spread and succumbed to persistent disease. The cases described here demonstrate the clinicopathological difficulties presented by this entity and its aggressive, unpredictable behaviour.

Laryngeal Myofibroblastic Tumor: A New Therapeutic Approach. A Case Report

“…1 In this regard, Kichenaradjou et al recommend longer follow-up periods due to the unpredictable behavior of these tumors. 12 However, the follow-up period we employed is in line with that published by the majority of the authors: Tay and Balakrishnan (12 months), 2 Yan and Hu (12 months), 6 Suzuki et al (14 months), 7 Do et al (6 months), 9 Kieu et al (12 months), 10 Girardi et al (14 months). 13 We have considerably reduced the comorbidity and suffering of these patients by applying these measures.…”

“…Due to the high recurrence and morbidity rates associated with surgery and the good response to corticosteroids, some authors prefer to use corticosteroids as initial therapy. 1,3, [10][11][12][13][14] In our case, we used methylprednisolone as first-line treatment instead of surgery. The lesion is in complete remission.…”

Intraosseous inflammatory pseudotumor of the maxilla: A case report

“…In a recent report by Neronov et al, 25 cases of intraosseous IPT of the jaw were reported, with the mandible being the most affected. After an extensive literature search, less than 10 cases of maxillary IPT were found, 3 , 11 , 12 all of which were osteolytic. Two cases were on the right side, and seven were on the left.…”

Maxillary Inflammatory Myofibroblastic Tumor

“…Radiotherapy can be employed as therapeutic modality instead of oral corticosteroid therapy and has been known to produce tumor free survival [11].…”