Inflammatory response to a marathon run in amateur athletes

Kaleta-Duss, Anna Maria; Lewicka-Potocka, Zuzanna; Dąbrowska−Kugacka, Alicja; Raczak, Grzegorz; Siekierzycka, Anna; Woźniak, Marcin; Kalinowski, Leszek; Lewicka, Ewa

doi:10.31373/ejtcm/136659

Cited by 4 publications

(3 citation statements)

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“…As previously reported elsewhere 24,25 , marathon running led to an elevation in the cardiovascular stress biomarkers such as cardiac troponin I (cTnI), endothelin-1 (ET-1), galectin-3 (Gal-3), pentraxin-3 (PTX-3), human growth differentiation factor 15 (GDF-15), and neopterin. The novelty of the data presented here includes TMAO and TMA results.…”

Section: Introductionsupporting

confidence: 53%

Section: Study Groupmentioning

confidence: 99%

“…Study participants were asked to avoid high-intensity training and participation in competitions for the following two weeks after completing the marathon. The observations presented are based on reported studies 24,25 . Because of the availability of the sample for the analysis of the present study, 28 of the original 35 subjects have been investigated.…”

Section: Study Groupmentioning

confidence: 99%

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Cardiovascular Stress Biomarkers in Response to Marathon Running in Male Athletes with Various Plasma Trimethylamine N-oxide Levels

Siekierzycka,

Radulska,

Woźniak

et al. 2024

Preprint

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Habitual physical activity is known to support cardiovascular health. However, when intensive exercise is performed for long durations, it can negatively affect the cardiovascular system. We evaluated the exercise-induced physiological responses of cardiac markers in male marathon runners with basal levels of trimethylamine-N-oxide (TMAO) plasma below (LT) and equal or above (HT) value of 4.0 µM. Blood samples from 28 marathon runners were collected two weeks before the marathon run (control before), after finishing the race (post-marathon), and two weeks after the race (control after). Serum cardiac troponin I (cTnI), endothelin-1 (ET-1), galectin-3, pentraxin-3, human growth differentiation factor 15, and neopterin were determined by the enzyme immunoassay method. Plasma trimethylamine and TMAO were measured by the ultra-high-performance liquid chromatography-mass spectrometry method. Running a marathon increased level of circulating stress biomarkers. A greater post-marathon elevation of cTnI and ET-1 was associated with higher plasma TMAO levels in the control samples prior to the marathon. A significant increase in ET-1 in post-marathon HT samples may indicate increased blood pressure and myocardial load due to increased vascular tone. Such an increase leads to greater myocardial cell membrane permeability and cTnI release. These modifications were not associated with other determined cardiovascular and inflammatory markers.

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Section: Introductionsupporting

confidence: 53%

Section: Study Groupmentioning

confidence: 99%

Section: Study Groupmentioning

confidence: 99%

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