Inflammatory response to acute hypoxia in humans

Burki, N. K.; Tetenta, Sodienye

doi:10.1016/j.pupt.2013.05.008

Cited by 8 publications

(6 citation statements)

References 31 publications

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“…This study was one of the few valuable clinical studies on this topic [ 24 - 28 ]. To the best of our knowledge, this was the first report comparing the HIF-1α levels after open and/or endovascular revascularization.…”

Section: Discussionmentioning

confidence: 99%

Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?

Yücel

Gürsoy

Ketenciler

et al. 2021

Vasc Specialist Int

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Section: Discussionmentioning

confidence: 99%

Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?

Yücel

Gürsoy

Ketenciler

et al. 2021

Vasc Specialist Int

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“…In contrast, a study examining the effect of exercise in normobaric hypoxia on oxidative stress demonstrated that moderate-intensity activity lowers oxidative stress, advocating that exercise is protective against AMS and not causative [40]. It was not possible to acquire continuous oxygen saturation data due to the physical demands for the polar workers, but changes in EPO and VEGF were examined as an indirect marker of hypoxic burden, as EPO and VEGF are mainly angiogenic factors that are known to be elevated during hypoxemia to maintain oxygen homeostasis [41][42][43]. In this study, venous blood samples indicated a greater elevation in EPO and VEGF in the individuals with AMS, which may be a result of exacerbated tissue hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Activity Patterns to Acute Mountain Sickness in South Pole Workers

et al. 2019

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This study aimed to evaluate the influence of physical activity on incidence of acute mountain sickness (AMS) by continuous activity monitoring in a free-living sample of South Pole workers over the initial 72 h at altitude exposure of 2,840 m (9,318 ft). Body Media activity monitors were worn by 47 healthy participants. AMS was defined by the Lake Louise symptom questionnaire. Venous blood samples were taken at sea level and approximately 48 h after high altitude exposure. AMS incidence was 34% (n=16/47) over the first 48 h and 40% (n=19/47) over 72 h. On day 2 at high altitude, individuals with AMS demonstrated a significantly greater increase in the percent change in physical activity metrics from baseline: total energy expenditure 19±13 vs. 5±7%, total steps 65±51 vs. 10±18%, metabolic equivalent of tasks 21±13 vs. 7±13%, and time spent performing moderate to vigorous physical activity 114±79 vs. 26±27% for individuals with AMS vs. no AMS, respectively, p<0.05. In addition, erythropoietin and vascular endothelial growth factor were 1.69 and 1.75 times higher, respectively, in those with AMS. In conclusion, workers who engaged in increased physical activity and activity intensity during initial exposure to the South Pole were more susceptible to developing AMS.

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“…Within the cerebrovasculature, acute hypoxia also induces changes in vascular function to maintain tissue oxygenation, including increases in blood flow in the vertebral artery (Ogoh et al 2013) and vasodilation of the cerebral arteries (Wilson et al 2011). Acute increases are also seen in a number of circulating factors including IL-6 (Hartmann et al 2000), HSP72 (Taylor et al 2010), and VEGF (Burki and Tetenta 2014).…”

Section: Hypoxia-based Interventionsmentioning

confidence: 99%

Non-pharmacological interventions for vascular health and the role of the endothelium

et al. 2022

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The most common non-pharmacological intervention for both peripheral and cerebral vascular health is regular physical activity (e.g., exercise training), which improves function across a range of exercise intensities and modalities. Numerous non-exercising approaches have also been suggested to improved vascular function, including repeated ischemic preconditioning (IPC); heat therapy such as hot water bathing and sauna; and pneumatic compression. Chronic adaptive responses have been observed across a number of these approaches, yet the precise mechanisms that underlie these effects in humans are not fully understood. Acute increases in blood flow and circulating signalling factors that induce responses in endothelial function are likely to be key moderators driving these adaptations. While the impact on circulating factors and environmental mechanisms for adaptation may vary between approaches, in essence, they all centre around acutely elevating blood flow throughout the circulation and stimulating improved endothelium-dependent vascular function and ultimately vascular health. Here, we review our current understanding of the mechanisms driving endothelial adaptation to repeated exposure to elevated blood flow, and the interplay between this response and changes in circulating factors. In addition, we will consider the limitations in our current knowledge base and how these may be best addressed through the selection of more physiologically relevant experimental models and research. Ultimately, improving our understanding of the unique impact that non-pharmacological interventions have on the vasculature will allow us to develop superior strategies to tackle declining vascular function across the lifespan, prevent avoidable vascular-related disease, and alleviate dependency on drug-based interventions.

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Inflammatory response to acute hypoxia in humans

Cited by 8 publications

References 31 publications

Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?

Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?

Relationship of Activity Patterns to Acute Mountain Sickness in South Pole Workers

Non-pharmacological interventions for vascular health and the role of the endothelium

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