Inflammatory responses and morphological changes of radiofrequency‐induced rat sciatic nerve fibres

Choi, Samjin; Choi, Hyunsu; Cheong, Youjin; Chung, Sunyang; Park, H.K.; Lim, Young-Jin

doi:10.1002/j.1532-2149.2013.00391.x

Cited by 23 publications

(23 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pulsed radiofrequency is a short intermittent pulse with 480 ms heat dissipation interval so that the temperature acting on the tissue does not exceed 42 • C. It does not cause nerve damage (Choi et al, 2014), only plays a role in neuromodulation (Lee et al, 2015). Therefore, PRF can act on the cervical nerve root for upper extremity PHN.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Pulsed Radiofrequency to Cervical Nerve Root for Postherpetic Neuralgia in Upper Extremity

Ding

Hong

et al. 2020

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Efficacy of Pulsed Radiofrequency to Cervical Nerve Root for Postherpetic Neuralgia in Upper Extremity

Ding

Hong

et al. 2020

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…was found to be exclusively expressed in astrocytes (50). Meanwhile, PRF may activate the expression of several types of cytokines (40). Overall, PRF application can directly and indirectly modulate neuron-glia-mediated spinal sensitization and neuroinflammation.…”

Section: Delayed Prf Effects: Prolonged Analgesia and P-erk Inhibitiomentioning

confidence: 99%

“…Though PRF can exert both thermal field (T-field) and electric field (E-field) effects, it generates stronger Efield and transmembrane potentials in neurons, but much lower T-field and temperature in comparison with CRF (8). E-field of PRF causes various degrees of microinjury in DRG neurons (10,(12)(13)(14)(15)39), but most damage is very mild and reversible within 4 weeks (40). Since E-field gradient across neural membrane is influenced by numerous factors such as the thickness of the myelin sheet, unmyelinated C-fibers may be vulnerable to Efield exposure (14).…”

Section: Wwwpainphysicianjournalcommentioning

confidence: 99%

Rapid and Delayed Effects of Pulsed Radiofrequency on Neuropathic Pain: Electrophysiological, Molecular, and Behavioral Evidence Supporting Long-Term Depression

Wen

2017

Pain Phys

View full text Add to dashboard Cite

Background: Pulsed radiofrequency (PRF) has been widely employed for ameliorating clinical neuropathic pain. How PRF alters electrophysiological transmission and modulates biomolecular functions in neural tissues has yet to be clarified. We previously demonstrated that an early application of low-voltage bipolar PRF adjacent to the dorsal root ganglion (DRG) reduced acute neuropathic pain in animals. By contrast, the present study investigated how PRF alters postsynaptic sensitization to produce early and delayed effects on neuropathic pain. Objectives: Our objective was to test the hypothesis that a 5-minute session of PRF could rapidly produce selective long-term depression (LTD) on C-fiber-mediated spinal sensitization and sustain the effect through the long-lasting inhibition of injury-induced ERK–MAPK activation. This may explain the prolonged analgesic effect of PRF on chronic neuropathic pain. Study Design: Experiments were conducted on both normal rats and neuropathic pain rats that received spinal nerve ligation (SNL) 8 days prior. Setting: An animal laboratory in a medical center of a university in Taiwan. Methods: We first compared changes in field potentials in the L5 superficial spinal dorsal horn (SDH) that were evoked by conditioning electrical stimuli in the sciatic nerve in male adult rats before (as the baseline) and after PRF stimulation for at least 2 hours. Bipolar PRF was applied adjacent to the L5 DRG at an intensity of 5 V for 5 minutes, whereas the control rats were treated with sham applications. The electrophysiological findings were tested for any correlation with induction of spinal phospho-ERK (p-ERK) in normal and neuropathic pain rats. We then investigated the delayed effect of PRF on SNL-maintained pain behaviors for 2 weeks as well as p-ERK in SDH among the control, SNL, and PRF groups. Finally, potential injury in the DRGs after PRF stimulation was evaluated through behavioral observations and ATF-3, a neuronal stress marker. Results: In the evoked field-potential study, the recordings mediated through A- and C-afferent fibers were identified as A-component and C-component, respectively. PRF significantly reduced the C-components over 2 hours in both the normal and SNL rats, but it did not affect the A-components. In the SNL rats, the C-component was significantly depressed in the PRF group compared with the sham group. PRF also inhibited acute p-ERK induced by mechanical nociception in both the control and SNL rats. For a longer period, PRF ameliorated SNL-maintained mechanical allodynia for 10 days and thermal analgesia for 14 days, and it significantly reduced late ERK activation within spinal neurons and astrocytes 14 days afterward. Moreover, PRF in the normal rats did not alter basal withdrawal thresholds or increase the expression and distribution of ATF-3 in the DRGs. Limitations: Several issues should be considered before translating the animal results to clinical applicationsConclusion: Low-voltage bipolar PRF produces LTD through selective suppression on the C-component, but not on the A-component. It also inhibits ERK activation within neurons and astrocytes in SDHs. The findings suggest that PRF alleviates long-lasting neuropathic pain by selectively and persistently modulating C-fiber-mediated spinal nociceptive hypersensitivity. Key words: Pulsed radiofrequency (PRF), dorsal root ganglion (DRG), neuropathic pain, ERK activation, evoked field potential, ATF-3, long-term depression (LTD), spinal nerve ligation (SNL)

show abstract

“…At the cytokine levels, PRF could upregulate the expression of glia cell line-derived neurotrophic factor (33), decrease the presynaptic release of glutamate and citrulline (34), and induce spinal descending inhibitory pathways via 5-hydroxytryptamine 3 and α2 receptors (35). However, Choi et al (36) found that the expression of inflammatory proteins in the PRF and CRF groups was upregulated. The upregulated expression of inflammatory cytokines in the PRF group returned to normal after one month.…”

Section: Crf Pcrfmentioning

confidence: 99%

Combination of Pulsed Radiofrequency with Continuous Radiofrequency Thermocoagulation at Low Temperature Improves Efficacy and Safety in V2/V3 Primary Trigeminal Neuralgia

Ding

Hong

et al. 2018

Pain Phys

View full text Add to dashboard Cite

Background: Primary trigeminal neuralgia (TN) is a common clinical refractory neuralgia. Severe pain is experienced during episodes, severely impacting the patient’s quality of life. Long-term suffering from the disease can lead to anxiety, depression, and even suicide. The pathological processes involved in TN are complex, the mechanisms of pathogenesis are unknown, and effective treatment is lacking. Objective: This study aimed to assess the efficacy and safety of computed tomography (CT)- guided pulsed radiofrequency (PRF) combined with low-temperature continuous radiofrequency (CRF) thermocoagulation in V2/V3 primary trigeminal neuralgia. Study Design: This research used a retrospective comparative study design. Setting: The research took place at Shengjing Hospital of China Medical University. Methods: A total of 80 hospitalized patients with TN were selected between January 2014 and December 2015 and randomly assigned to 2 groups differentiated by therapeutic method: CRF (CRF group, n = 40) and PRF + CRF (PCRF group, n = 40). Radiofrequency therapy was performed under the guidance of CT. Follow-up measures assessed preoperative conditions, pain remission, complications and side effects, recovery time, and recurrence rate over the 2 years following the surgery. Results: The Visual Analog Scale (VAS) scores decreased in both groups after surgery. After one month, the decrease in the VAS score in the PCRF group was more apparent, and this difference was maintained for 2 years. The total efficiency rates in the CRF and PCRF groups were 85% and 97.5%, respectively, at 6 months, 1 year, and 2 years post-surgery. The differences in total efficiency rate of pain between the 2 groups at 6 months, 1 year, and 2 years were statistically significant. Recovery times in the PCRF group were shorter than those in the CRF group. Specifically, recovery times for facial numbness in the CRF and PCRF groups were 3.12 ± 1.21 months and 2.23 ± 1.02 months, respectively. Recovery times for masticatory muscle weakness were 4.33 ± 1.54 months and 3.42 ± 0.98 months, respectively. Limitations: This study is limited by being a retrospective study, and by having a relatively small sample size from a single center. Conclusions: CT-guided PRF combined with low-temperature CRF thermocoagulation for treating V2/V3 primary TN effectively relieves pain, increases late-stage pain remission rate, reduces complications, and reduces the rate of recurrence. Key words: Complication, continuous radiofrequency thermocoagulation, pulsed radiofrequency, recurrence rate, trigeminal neuralgia, Visual Analog Scale

show abstract

Inflammatory responses and morphological changes of radiofrequency‐induced rat sciatic nerve fibres

Cited by 23 publications

References 31 publications

Efficacy of Pulsed Radiofrequency to Cervical Nerve Root for Postherpetic Neuralgia in Upper Extremity

Efficacy of Pulsed Radiofrequency to Cervical Nerve Root for Postherpetic Neuralgia in Upper Extremity

Rapid and Delayed Effects of Pulsed Radiofrequency on Neuropathic Pain: Electrophysiological, Molecular, and Behavioral Evidence Supporting Long-Term Depression

Combination of Pulsed Radiofrequency with Continuous Radiofrequency Thermocoagulation at Low Temperature Improves Efficacy and Safety in V2/V3 Primary Trigeminal Neuralgia

Contact Info

Product

Resources

About