Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors

Tuet, Wing Y.; Chen, Yunle; Fok, Shierly; Champion, Julie A.; Ng, N. L.

doi:10.5194/acp-17-11423-2017

Cited by 82 publications

(142 citation statements)

References 111 publications

(156 reference statements)

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“…Also cellular tests with an ROS probe have been developed to measure ROS induced by aerosols in a biological system (Landreman et al, 2008;Zhang et al, 2016;Tuet et al, 2017). The DCFH (2 ,7 -dichlorofluorescin) assay has been shown to be sensitive to a broad range of organic peroxides, alkyl peroxide radicals, and hypochlorite, but not to components that are known to induce redox cycling (i.e., metal ions and quinones; Venkatachari and Hopke, 2008;Wang et al, 2011b;King and Weber, 2013;G. W. Fuller et al, 2014;.…”

Section: Introductionmentioning

confidence: 99%

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Particle-bound reactive oxygen species (PB-ROS) emissions and formation pathways in residential wood smoke under different combustion and aging conditions

et al. 2018

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Abstract. Wood combustion emissions can induce oxidative stress in the human respiratory tract by reactive oxygen species (ROS) in the aerosol particles, which are emitted either directly or formed through oxidation in the atmosphere. To improve our understanding of the particle-bound ROS (PB-ROS) generation potential of wood combustion emissions, a suite of smog chamber (SC) and potential aerosol mass (PAM) chamber experiments were conducted under well-determined conditions for different combustion devices and technologies, different fuel types, operation methods, combustion regimes, combustion phases, and aging conditions. The PB-ROS content and the chemical properties of the aerosols were quantified by a novel ROS analyzer using the DCFH (2′,7′-dichlorofluorescin) assay and a high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS). For all eight combustion devices tested, primary PB-ROS concentrations substantially increased upon aging. The level of primary and aged PB-ROS emission factors (EFROS) were dominated by the combustion device (within different combustion technologies) and to a greater extent by the combustion regimes: the variability within one device was much higher than the variability of EFROS from different devices. Aged EFROS under bad combustion conditions were ∼ 2–80 times higher than under optimum combustion conditions. EFROS from automatically operated combustion devices were on average 1 order of magnitude lower than those from manually operated devices, which indicates that automatic combustion devices operated at optimum conditions to achieve near-complete combustion should be employed to minimize PB-ROS emissions. The use of an electrostatic precipitator decreased the primary and aged ROS emissions by a factor of ∼ 1.5 which is however still within the burn-to-burn variability. The parameters controlling the PB-ROS formation in secondary organic aerosol were investigated by employing a regression model, including the fractions of the mass-to-charge ratios m∕z 44 and 43 in secondary organic aerosol (SOA; f44−SOA and f43−SOA), the OH exposure, and the total organic aerosol mass. The regression model results of the SC and PAM chamber aging experiments indicate that the PB-ROS content in SOA seems to increase with the SOA oxidation state, which initially increases with OH exposure and decreases with the additional partitioning of semi-volatile components with lower PB-ROS content at higher OA concentrations, while further aging seems to result in a decay of PB-ROS. The results and the special data analysis methods deployed in this study could provide a model for PB-ROS analysis of further wood or other combustion studies investigating different combustion conditions and aging methods.

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Section: Introductionmentioning

confidence: 99%

“…W. Fuller et al, 2014;. The DCFH assay has fast response rates and a linear response to varying ROS concentrations, for which reason it was applied as a suitable measure for the PB-ROS concentration (Zhou et al, 1997;Venkatachari and Hopke, 2008;Weber, 2013, Zhou et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Particle-bound reactive oxygen species (PB-ROS) emissions and formation pathways in residential wood smoke under different combustion and aging conditions

et al. 2018

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“…However, the SOA reactions concern the heterogenic aerosol chemistry section that is they are beyond the scope of our study. For more details about the SOA paths, please see the studies in Reference [65][66][67][68]. Therefore, we distinguish the quasi-heterogeneous gas chemistry and the heterogeneous gas chemistry.…”

Section: Discussionmentioning

confidence: 99%

Isoprene, Methyl Vinyl Ketone and Methacrolein from TROICA-12 Measurements and WRF-CHEM and GEOS-CHEM Simulations in the Far East Region

et al. 2019

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Spatial and temporal distributions of isoprene and its oxidation products, methyl vinyl ketone and methacrolein in the Far East region of Russia were investigated. The measurement data were obtained from a mobile laboratory, which moved along the Trans-Siberian railway and from WRF-CHEM (Weather Research and Forecasting Chemical Model) and GEOS-CHEM (Goddard Earth Observing System Chemical Model) simulations. During the simulations, the RACM-MIM and MOZART mechanisms, included in the mesoscale WRF-CHEM model, as well as the Caltech Isoprene Scheme (CIS), built in the global GEOS-CHEM model, have been used. We found that the temporal distribution of the measured isoprene is in good agreement with the simulations. The measured isoprene, methyl vinyl ketone (MVK) and methacrolein (MACR) concentrations demonstrate pronounced diurnal variations. The correlation between the measured isoprene and MVK + MACR was good (R ~ 0.60–0.86). However, the simulated correlation between MVK + MACR and isoprene is very low, with the data for the night-time and daytime values varying. The simulated MVK + MACR to isoprene ratio, in comparison with the experimental result, has pronounced diurnal variations. During twilight and the night-time, the simulated MVK + MACR to isoprene ratio is more than 10. We propose that, due to the validity of the kinetic equations only in the homogeneous system, all chemical and transport (CTM) models, based on these kinetic equations, are not able to show an adequate simulation at night in the weak mixing atmosphere, when the atmospheric structure becomes heterogeneous. At moderate latitudes, we recommend the use of the turbulent Damköhler number and the Kolmogorov Damköhler numbers, which characterize the limits of CTM applicability, as the quality flags at the air quality forecast simulations.

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“…Various experiments have also shown that pure SOA does induce adverse effects upon exposure of airway epithelial cells (Arashiro et al, 2016(Arashiro et al, , 2018Gaschen et al, 2010;Lin et al, 2016;Chowdury et al, 2018;Jiang et al, 2016). Similarly, cellular based ROS assays show a strong connection with pure SOA or its fraction in PM (Tuet et al, 2016;Tuet et al, 2017a;Tuet et al, 2017b;Saffari et al, 2014). Further, Lakey et al (2016) developed a model to simulate the response of air pollutants including PM on the production rates and concentrations of ROS in the epithelial lining fluid of the human respiratory tract.…”

Section: Atmospheric Implicationsmentioning

confidence: 99%

Predominance of Secondary Organic Aerosol to Particle-bound Reactive Oxygen Species Activity in Fine Ambient Aerosol

Zhou¹,

Elser²,

Huang³

et al. 2019

Preprint

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<p><strong>Abstract.</strong> Reactive oxygen species (ROS) are believed to contribute to the adverse health effects of aerosols. This may happen by inhaled particle-bound (exogenic) ROS (PB-ROS) or by ROS formed within the respiratory tract by certain aerosol components (endogenic ROS). We investigated the chemical composition of aerosols and their exogenic ROS content at the two contrasting locations Beijing (China) and Bern (Switzerland). We apportioned the ambient organic aerosol to different sources and attributed the observed PB-ROS to them. The oxygenated organic aerosol (OOA, a proxy for secondary organic aerosol, SOA) explained the highest fraction of the exogenic ROS concentration variance at both locations. We also characterized primary and secondary aerosol emissions generated from different biogenic and anthropogenic sources in smog chamber experiments. The exogenic PB-ROS content in the OOA from these emission sources was comparable to that in the ambient measurements. Our results imply that SOA from gaseous precursors of different anthropogenic emission sources is a crucial source of PB-ROS and should be additionally considered in toxicological and epidemiological studies in an adequate way besides primary emissions. The importance of PB-ROS may be connected to the seasonal trends in health effects of PM reported by epidemiological studies, with elevated incidences of adverse effects in warmer seasons, which are accompanied by more intense atmospheric oxidation processes.</p>

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Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors

Cited by 82 publications

References 111 publications

Particle-bound reactive oxygen species (PB-ROS) emissions and formation pathways in residential wood smoke under different combustion and aging conditions

Particle-bound reactive oxygen species (PB-ROS) emissions and formation pathways in residential wood smoke under different combustion and aging conditions

Isoprene, Methyl Vinyl Ketone and Methacrolein from TROICA-12 Measurements and WRF-CHEM and GEOS-CHEM Simulations in the Far East Region

Predominance of Secondary Organic Aerosol to Particle-bound Reactive Oxygen Species Activity in Fine Ambient Aerosol

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