Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female

Soro, Luis; Gust, Anthony; Purcell, Stephen M

doi:10.4103/2229-5178.120662

Cited by 17 publications

(16 citation statements)

References 6 publications

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“…The presence of CD8-positive lymphocytes tagging the dermoepidermal junction as well as ringing melanocytes is in line with recent work in murine models implicating CD8-positive cells as the effectors of melanocyte death [7]. Other reports in the literature describe the inflammatory border of IVRB as presenting with band-like infiltration of lymphocytes in the upper dermis, including CD4-positive and CD8-positive cells (see table 1 for selected examples) [2,8,11,12]. Le Poole et al [6] suggest that HLA-DR expression along stretches of basal and suprabasal keratinocytes may contribute to local T cell reactivity.…”

Section: Discussionsupporting

confidence: 64%

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Gunasekera

Murphy²,

Sheth³

2014

Dermatology

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Inflammatory vitiligo with raised borders (IVRB) is a rare subtype of vitiligo described as having a rim of raised erythema at the periphery of the depigmented patches. The etiology is poorly understood, and there are few reports of successful treatment of the condition in the literature. We report a 38-year-old South Asian male who presented with diffuse depigmented macules and patches surrounded by blue-gray rims involving a large body surface area. Light microscopy revealed inflammatory vitiligo. He was treated with 2 courses of oral prednisone and whole-body narrow-band ultraviolet B (NB-UVB) therapy, which resulted in cessation of disease spread as well as substantial repigmentation. Our observation suggests that early and aggressive treatment can lead to significant and rapid improvement in patients with IVRB.

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Section: Discussionsupporting

confidence: 64%

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Gunasekera

Murphy²,

Sheth³

2014

Dermatology

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“…Due to its inflammatory aspect, we recorded whether other concomitant diseases were reported (Table ). Autoimmunity was reported in 11 cases of these 25 cases . Inflammatory vitiligo needs to be differentiated from other dermatoses (e.g.…”

Section: Resultsmentioning

confidence: 99%

“…These inflammatory symptoms are described as ‘rare’ cases. Raised borders have been reported to affects less than 5% of all vitiligo cases, while another study reported erythema, scaling and/or hyperpigmentation in 13% . Due to its inflammatory aspect, we recorded whether other concomitant diseases were reported (Table ).…”

Section: Resultsmentioning

confidence: 99%

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Clinical visible signs of disease activity in vitiligo: a systematic review and meta‐analysis

Geel

Grine

Wispelaere

et al. 2019

Acad Dermatol Venereol

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Vitiligo is an unpredictable depigmenting disorder for which a static method to assess disease activity is lacking. Presence of certain skin manifestations may be indicative of disease activity. Here, we evaluated the current evidence for an association between clinical signs and reported disease activity in vitiligo. A systematic review and meta‐analysis was performed based on a search in PubMed, Embase and Cochrane Library. Literature reporting skin manifestations and disease activity was analysed based on descriptive analyses and, if applicable, odd ratios. Forty‐six observational studies were selected and analysed, including 28 case reports. Reported clinical signs in relation to active vitiligo were as follows: Koebner's phenomenon, confetti‐like depigmentations, tri‐ and hypochromic lesions (including poorly defined borders), inflammatory borders/areas, itch and leukotrichia. Based on this search, strong evidence was found for Koebner's phenomenon. Poorly defined borders and confetti lesions are potential markers, although more data are needed to confirm this. Evidence for other skin manifestations was inconclusive, whereas case reports on inflammatory borders were indicative of active disease. Limitations included the lack of randomized controlled trials, large‐scale prospective studies and heterogeneity due to inconsistent definitions. This systematic review urges the vitiligo community to come forward with consensus‐based definitions as well as a reliable scoring system to assess these clinical signs and to design optimal trials to investigate their true predictive value.

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“…A diagnosis was given to each case based on constellation of clinical and histopathological findings and according to criteria described in the literature. 3,4,[7][8][9][10][11][12][13][14] Data were coded and entered using Statistical Package for Special Science (SPSS) software computer program version 15. Data were described as mean 6 SD for quantitative (numerical) variables and as frequency and percentage for qualitative (categorical) variables.…”

Section: Methodsmentioning

confidence: 99%

Frequency of Hypopigmented Mycosis Fungoides in Egyptian Patients Presenting With Hypopigmented Lesions of the Trunk

Abdel‐Halim

El‐Nabarawy

Nemr³

et al. 2015

The American Journal of Dermatopathology

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Hypopigmented mycosis fungoides (HMF) is an uncommon variant of mycosis fungoides with an unknown exact frequency. We aimed to study the frequency of HMF in a cohort of Egyptian patients presenting to a tertiary care center in Cairo, Egypt, with hypopigmented lesions of the trunk. Hundred patients with hypopigmented lesions involving the trunk (with or without other sites involvement) were subjected to thorough clinical and histopathological examination. Immunohistochemical studies (S100, CD4, and CD8) were performed when indicated. Constellation of findings was used to reach a final diagnosis. Sixteen cases had HMF (16%). Other than HMF, our cohort included hypopigmented parapsoriasis en plaque (42 cases), postinflammatory hypopigmentation (28 cases), progressive macular hypomelanosis (12 cases), and pityriasis alba (2 cases). In comparison with other hypopigmented disorders, HMF was significantly associated with progressive disease course (P = 0.004), affection of distal upper limbs (P = 0.005), proximal lower limbs (P = 0.003), large-sized lesions (>5 cm) (P < 0.0001), well-defined margin (P < 0.0001), scaliness (P = 0.002), erythema (P < 0.0001), atrophy (P = 0.012), and mottled pigmentation (P < 0.0001). Awareness of HMF and its characteristic clinical features is mandatory to avoid underdiagnosis or overdiagnosis with subsequent morbidity or unnecessary aggressive therapy, respectively.

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Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female

Cited by 17 publications

References 6 publications

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Clinical visible signs of disease activity in vitiligo: a systematic review and meta‐analysis

Frequency of Hypopigmented Mycosis Fungoides in Egyptian Patients Presenting With Hypopigmented Lesions of the Trunk

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