Infliximab for Behçet disease with aortic involvement: two novel case reports without concurrent use of immunosuppressive agents or corticosteroids

Effects of immunosuppressive drugs on oral mucosa in patients with Behçet’s disease: cytomorphological and cytopathological assessment

“…The use of immunosuppressive drugs can be associated with a number of adverse effects in many patients, and they can increase the risk of many diseases, such as hypertension, cancer (27,28), renal impairment (29)(30)(31), and skin atrophy (32,33). A number of studies have reported that immunosuppressive drugs (colchicine, cyclosporine, and infliximab) caused some pathologies, including aortic involvement, lower serum creatinine, and nephrotoxicity, in patients with BD (30,31,34). BD patients may be at a higher risk of such diseases because of longer periods of drug administration.…”

Vascular Manifestations of Behçet’s Disease

“…Several case reports showed the efficacy of antitumor necrosis factor-alpha (TNF-α) agents for BD patients with complications of vascular involvement, such as PAA, aortitis, and deep vein thrombosis. But only a limited number of studies about these agents have been published [91][92][93][94]. In contrast, several studies have raised caution regarding the possibility of development of thrombophlebitis as a side effect of infliximab in BD patients [95,96].…”