Infliximab‐induced neutrophilic eccrine hidradenitis in a patient with hidradenitis suppurativa

Feraru, Guy; Dodiuk‐Gad, Roni P.; Krausz, Judit; Ziv, Michael

doi:10.1111/dth.13900

Cited by 3 publications

(3 citation statements)

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“…However, where pathergy testing is conducted, one extra point may be assigned for a positive result International Study Group for Behçet's Disease criteria [109] International Criteria for Behçet's Disease [110] One inhibitors (adalimumab), antiretrovirals, immunosuppressants (azathioprine), and anticonvulsants (carbamazepine) [127]. Recently, NEH has been reported with infliximab, ticagrelor, and pegfilgrastim [128][129][130]. In healthy children, NEH is an idiopathic benign, self-limited eruption that tends to occur in summer months called idiopathic plantar hidradenitis (IPH) [131].…”

Section: Epidemiologymentioning

confidence: 99%

“…Other associated medications include antipyretics (acetaminophen), TNF inhibitors (adalimumab), antiretrovirals, immunosuppressants (azathioprine), and anticonvulsants (carbamazepine) [ 127 ]. Recently, NEH has been reported with infliximab, ticagrelor, and pegfilgrastim [ 128 – 130 ]. In healthy children, NEH is an idiopathic benign, self-limited eruption that tends to occur in summer months called idiopathic plantar hidradenitis (IPH) [ 131 ].…”

Section: Neutrophilic Eccrine Hidradenitismentioning

confidence: 99%

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Neutrophilic Dermatoses: a Clinical Update

Weiss

Leung

et al. 2022

Curr Derm Rep

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Purpose of Review Neutrophilic dermatoses are defined by the presence of a sterile neutrophilic infiltrate on histopathology. This review focuses on the pathogenesis, epidemiology, clinicopathological features, diagnosis, and management of four disorders: Sweet syndrome, pyoderma gangrenosum, Behçet syndrome, and neutrophilic eccrine hidradenitis.Recent Findings Recent studies have provided insight into the complex pathogenesis of neutrophilic dermatoses. Evidence supports an intricate interplay of abnormal neutrophil function and inflammasome activation, malignant transformation into dermal infiltrating neutrophils, and genetic predisposition. Summary Neutrophilic dermatoses have diverse cutaneous and extracutaneous manifestations and may be associated with significant morbidity and mortality. Common underlying associations include infectious, inflammatory, and neoplastic disorders, as well as drug reactions. Emerging diagnostic and therapeutic frameworks identify an expanding role for biologic and targeted anti-inflammatory therapies. KeywordsAcute febrile neutrophilic dermatosis • Behçet disease • Neutrophilic dermatosis • Neutrophilic eccrine hidradenitis • Pyoderma gangrenosum • Sweet syndrome This article is part of the Topical Collection on Hospital-Based Dermatology

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Section: Epidemiologymentioning

confidence: 99%

Section: Neutrophilic Eccrine Hidradenitismentioning

confidence: 99%

Neutrophilic Dermatoses: a Clinical Update

Weiss

Leung

et al. 2022

Curr Derm Rep

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“…42,48,49 Although effective, cost, availability, and possible side effects of biological drugs need to be considered by clinicians in the ME. Recently, a patient with HS was reported in Israel 50 that developed with infliximab-induced neutrophilic eccrine hidradenitis after about 6 months of treatment. While efficacy of other potential biologics in HS treatment is not well studied in the region, in Turkey, 51 a case has been reported in which the use of canakinumab (IL-1 inhibitors) resulted in the worsening of HS.…”

Section: Biological Treatmentsmentioning

confidence: 99%

Trends in the management of hidradenitis suppurativa in the Middle East region: a systematic review

et al. 2020

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Background Hidradenitis suppurativa (HS) is a chronic, painful, and severely debilitating inflammatory disease that affects apocrine gland-bearing skin. There is no universal consensus on the management of hidradenitis suppurativa (HS). Current available guidelines are from western countries, which may be of limited use in other parts of the world. In this study, we aim to identify trends in the management of HS in the Middle East (ME) and its differences with the West. Methods A systematic literature review was performed to identify all studies in HS management performed by experts in the ME from database inception to June 2020 using PubMed, EMBASE, and Cochrane Library databases. Only original articles published in English language were included. Guidelines from western countries were used for comparison.Results Fifty-four eligible studies comprising 7649 HS patients from the ME region and nine guidelines from the West were included. No established guidelines were found for the management of HS in the ME. Sex ratio of HS patients in the ME is different in that men reported to be affected at a higher rate than in the West. Different antibiotic regimens were recommended in the ME, and the experts in the ME tend to be more procedure intensive than experts in the West.Conclusions Establishing a guideline for HS management in the ME is recommended to address unique considerations in the countries in this region.There is no universal consensus on the best management of HS. 4,5 Although several guidelines are available for clinicians, most of these are from experts in western countries. There is a shortage of such guidelines for non-western countries. This shortage is particularly significant given that ethnicity as well as genetic, environmental, and cultural factors can all affect the clinical course of the disease and therapeutic options. As such, we aim to review approaches to HS management in the Middle East (ME) and compare them with those of the West, providing recommendations for HS management in the ME region. MethodsWe conducted a comprehensive literature search for HS management guidelines from database inception (April 1992) to

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