Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis

Abstract

Our results suggest that infliximab could contribute to the control of intestinal inflammation by modifying adipokine production by mesenteric adipose tissue.

Telmisartan attenuates the inflamed mesenteric adipose tissue in spontaneous colitis by mechanisms involving regulation of neurotensin/microRNA-155 pathway

“…In a recent study, methotrexate treatment was found to be associated with the decreased production of inflammatory adipokines in reactivated animal colitis [68]. In addition to control intestinal inflammation, infliximab treatment could restore the adipocyte morphology and PPAR-g expression [69]. In line with previous reports, our data Fig.…”

Protective efficacy of ursodeoxycholic acid nanoparticles in animal model of inflammatory bowel disease

“…Extensive accumulation of inflammatory cells was not observed in colon tissue of UNPtreated animals. Furthermore, consequently, there was a lesser accumulation of MPO in the colon tissue of the UNP-treated group of animals as observed from tissue biochemical analysis (Figure 8a), which can be corroborated by other studies (Clemente et al, 2012;Takagi et al, 2012). The UNPs reached the colon and maintained a constant level of drug in colon and delivered the total drug load that prevented ulcer formation showing the protective efficacy of UDCA (de Souza Almeida et al, 2011).…”

Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation

“…6A). Monoclonal antibodies against TNF-␣ ameliorate inflammation and improve mucosal healing in animal models of experimental colitis (12,58). We predicted that, independent of sex and CRF 2 levels, administration of therapeutic monoclonal anti-TNF-␣ antibody should reduce inflammation.…”