Influence de l’arthrodèse vertébrale dorsale sélective T1–T6 sur la croissance thoracique : étude expérimentale chez des lapins New Zealand White prépubertaires

Canavese, Federico; Diméglio, Alain; Granier, M.; Beraldo, Paola; Bonnel, F.; Stebel, Marco; Daurès, Jean‐Pierre; Canavese, Bartolomeo; Cavalli, Fábio

doi:10.1016/j.rco.2008.04.002

Cited by 8 publications

(10 citation statements)

References 28 publications

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“…Alterations to any of these elements affect and change the development and growth of the others. Therefore, to preserve thoracic motility and permit a normal development of the respiratory tree, treatment should not only focus on the spine but also consider the rib-vertebral-sternal complex as a whole 1011242541…”

Section: Discussionmentioning

confidence: 99%

“…The inability of the thorax to ensure normal breathing and the accompanying serious respiratory insufficiency is characterized by the thoracic insufficiency syndrome. This clinical picture can be linked to costo-vertebral malformations, neuromuscular disease, syndromes such as Jeune and Jarcho-Levin, or to 50% fusion of the thoracic spine before the age of 7341011242541…”

Section: Discussionmentioning

confidence: 99%

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Effect of thoracic arthrodesis in prepubertal New Zealand white rabbits on cardio-pulmonary function

Canavese

Diméglio

Barbetta

et al. 2014

IJOO

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Background:This experimental study was aimed at evaluating the type of cardiac and pulmonary involvement, in relation to changes of the thoracic spine and cage in prepubertal rabbits with nondeformed spine following dorsal arthrodesis. The hypothesis was that T1-T12 arthrodesis modified thoracic dimensions, but would not modify cardiopulmonary function once skeletal maturity was reached.Materials and Methods:The study was conducted in 16 female New Zealand White (NZW) rabbits. Nine rabbits were subjected to T1-T12 dorsal arthrodesis while seven were sham-operated. Echocardiographic images were obtained at 12 months after surgery and parameters for 2-dimensional and M-mode echocardiographic variables were assessed. One week before echocardiographic examination, blood samples were withdrawn from the animals’ central artery of the left ear to obtain blood gas values. One week after echocardiographic assessment, a thoracic CT scan was performed under general anesthesia. Chest depth (CD) and width (CW), thoracic kyphosis (ThK) and sternal length (StL) were measured; thoracic index (ThI), expressed as CD/CW ratio. All subjects were euthanized after the CT scan. Heart and lungs were subsequently removed to measure weight and volume.Results:The values for 2-dimensional and M-mode echocardiographic variables were found to be uniformly and significantly higher, compared to those reported in anesthetized rabbits. CD, ThK, and StL were considerably lower in operated rabbits, as compared to the ones that were sham-operated. Similarly, the ThI was lower in operated rabbits than in sham-operated ones.Conclusion:Irregularities in thoracic cage growth resulting from thoracic spine arthrodesis did not alter blood and echocardiographic parameters in NZW rabbits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of thoracic arthrodesis in prepubertal New Zealand white rabbits on cardio-pulmonary function

Canavese

Diméglio

Barbetta

et al. 2014

IJOO

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“…Rabbits are sufficiently large, tolerate well GA and can be subjected to echocardiographic assessment [30][31][32][33][34] in the conscious state and allow easy blood withdrawals from artery and veins of the ears [13,14,23,[37][38][39][40][41]. Rabbits were prepubertal at the time of surgery and were followed for 1 year.…”

Section: Discussionmentioning

confidence: 99%

“…Thoracic cage shape was assessed on CT scan images. CT scans provide adequate images to allow the measurement of multiple thoracic cage parameters in arthrodesed rabbits [13,14].…”

Section: Discussionmentioning

confidence: 99%

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Thoracic cage plasticity in prepubertal New Zealand white rabbits submitted to T1–T12 dorsal arthrodesis: computed tomography evaluation, echocardiographic assessment and cardio-pulmonary measurements

et al. 2013

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Purpose We aimed to describe the morphological changes in the thoracic cage and spinal column induced in New Zealand White (NZW) prepubertal rabbits subjected to dorsal arthrodesis and observed at skeletal maturity by computed tomography (CT) scans. This was done to evaluate the plasticity of the thoracic cage of rabbits with non-deformed spine, by highlighting its modifications after spinal arthrodesis. Emogas data analysis, echocardiographic assessment and cardio-pulmonary measurements completed the evaluation.Methods Surgery was performed in 16 female rabbits, 6 weeks old. Nine were subjected to T1-T12 dorsal arthrodesis, while seven were sham-operated. Surgery involved the implant of two C-shaped stainless steel bars and heterologous bone graft. CT scans were performed before surgery, 2, 6 and 12 months after surgery. One week after the last CT scan, echocardiographic and emogas evaluations were performed. Results Chest depth (8 %), thoracic kyphosis (ThK) (23 %), dorsal and ventral length of the thoracic spine (11 %) and sternal length (7 %) were significantly reduced in operated compared to sham-operated rabbits. Mean values ± standard deviation (SD) of PaCO 2 , PaO 2 and sO 2 were not significantly different. Mean values ± SD of echocardiographic measurements were not significantly different between the two groups of rabbits, except for thickness of the interventricular septum in systole, contractile capacity of the left ventricle and ejection fraction. Conclusions T1-T12 dorsal arthrodesis in prepubertal NZW rabbits with non-deformed spine induced changes of the thoracic cage morphology. However, those changes are source of cardio-pulmonary complications not severe enough to reproduce a clinical picture comparable to thoracic insufficiency syndrome in humans.

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The growing spine: how spinal deformities influence normal spine and thoracic cage growth

2011

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Growth is a succession of acceleration and deceleration phases and a perfect knowledge of normal growth parameters is mandatory to understand the pathologic modifications induced on a growing spine by an early onset spinal deformity. The challenges associated with the growing spine for the surgeon include preservation of the thoracic spine, thoracic cage, and lung growth without reducing spinal motion.

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Influence de l’arthrodèse vertébrale dorsale sélective T1–T6 sur la croissance thoracique : étude expérimentale chez des lapins New Zealand White prépubertaires

Cited by 8 publications

References 28 publications

Effect of thoracic arthrodesis in prepubertal New Zealand white rabbits on cardio-pulmonary function

Effect of thoracic arthrodesis in prepubertal New Zealand white rabbits on cardio-pulmonary function

Thoracic cage plasticity in prepubertal New Zealand white rabbits submitted to T1–T12 dorsal arthrodesis: computed tomography evaluation, echocardiographic assessment and cardio-pulmonary measurements

The growing spine: how spinal deformities influence normal spine and thoracic cage growth

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