Influence de la co-infection paludéenne placentaire et VIH sur la biométrie et l’indice d’Apgar du nouveau-né à Kinshasa, République démocratique du Congo

O’yandjo, Antoine Modia; Foidart, Jean‐Michel; Rigo, Jacques

doi:10.1016/j.jgyn.2011.03.002

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Pregnancy is associated with increased susceptibility to malaria in areas where malaria is endemic [ 14 , 15 ]. The control of malaria and HIV in pregnant sub-Saharan African women has, however, been particularly challenging [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…HIV increases the degree to which malaria is associated with severe anemia and low birth weight beyond the effect of HIV itself on these outcomes. HIV also puts women of all gravidities at risk for placental infection with malaria, not only women in their first or second pregnancy [ 3 - 5 , 7 - 9 , 15 , 23 ]. In addition, higher HIV prevalence rates exceeding sometime 40% have been reported among pregnant women in malaria endemic region of Africa [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Interactions between malaria and HIV infections in pregnant women: a first report of the magnitude, clinical and laboratory features, and predictive factors in Kinshasa, the Democratic Republic of Congo

Wumba

Zanga

Aloni

et al. 2015

Malar J

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BackgroundHIV and malaria are among the leading causes of morbidity and mortality during pregnancy in Africa. However, data from Congolese pregnant women are lacking. The aim of the study was to determine the magnitude, predictive factors, clinical, biologic and anthropometric consequences of malaria infection, HIV infection, and interactions between malaria and HIV infections in pregnant women.MethodsA cross-sectional study was conducted among pregnant women admitted and followed up at Camp Kokolo Military Hospital from 2009 to 2012 in Kinshasa, the Democratic Republic of Congo. Differences in means between malaria-positive and malaria-negative cases or between HIV-positive and HIV-negative cases were compared using the Student’s t-test or a non-parametric test, if appropriate. Categorical variables were compared using the Chi-square or Fisher’s exact test, if appropriate. Backward multivariable analysis was used to evaluate the potential risk factors of malaria and HIV infections. The odds ratios with their 95% confidence interval (95% CI) were estimated to measure the strengths of the associations. Analyses resulting in values of P < 0.05 were considered significant.ResultsA malaria infection was detected in 246/332 (74.1%) pregnant women, and 31.9% were anaemic. Overall, 7.5% (25/332) of mothers were infected by HIV, with a median CD4 count of 375 (191; 669) cells/μL. The mean (±SD) birth weight was 2,613 ± 227 g, with 35.7% of newborns weighing less than 2,500 g (low birth weight). Low birth weight, parity and occupation were significantly different between malaria-infected and uninfected women in adjusted models. However, fever, anemia, placenta previa, marital status and district of residence were significantly associated to HIV infection.ConclusionThe prevalence of malaria infection was high in pregnant women attending the antenatal facilities or hospitalized and increased when associated with HIV infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interactions between malaria and HIV infections in pregnant women: a first report of the magnitude, clinical and laboratory features, and predictive factors in Kinshasa, the Democratic Republic of Congo

Wumba

Zanga

Aloni

et al. 2015

Malar J

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TB and HIV in the Central African region: current knowledge and knowledge gaps

et al. 2013

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Despite the relatively high burden of HIV and TB in the Central African region, the amount of research activities on these topics is limited. A better understanding of the co-epidemics in this region is urgently needed. The occurrence of opportunistic infections, treatment complications and drug resistance in TB and HIV need to be better described; the failure of public health systems needs to be understood, and research infrastructure needs to be developed. Only then will it be possible to turn the tide against the HIV and TB epidemics in this region.

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Development, coinfection, and the syndemics of pregnancy in Sub-Saharan Africa

Singer

2013

Infect Dis Poverty

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Notable among gaps in the achievement of the global health Millennium Development Goals (MDG) are shortcomings in addressing maternal health, an issue addressed in the fifth MDG. This shortfall is particularly acute in Sub-Saharan Africa (SSA), where over half of all maternal deaths occur each year. While there is not as yet a comprehensive understanding of the biological and social causes of maternal death in SSA, it is evident that poverty, gendered economic marginalization, social disruptions, hindered access to care, unevenness in the quality of care, illegal and clandestine abortions, and infections are all critical factors. Beyond these factors, this paper presents a review of the existing literature on maternal health in SSA to argue that syndemics constitute a significant additional source of maternal morbidity and mortality in the region. Increasing focus on the nature, prevention, and treatment of syndemics, as a result, should be part and parcel of improving maternal health in SSA.

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Influence de la co-infection paludéenne placentaire et VIH sur la biométrie et l’indice d’Apgar du nouveau-né à Kinshasa, République démocratique du Congo

Cited by 6 publications

References 23 publications

Interactions between malaria and HIV infections in pregnant women: a first report of the magnitude, clinical and laboratory features, and predictive factors in Kinshasa, the Democratic Republic of Congo

Interactions between malaria and HIV infections in pregnant women: a first report of the magnitude, clinical and laboratory features, and predictive factors in Kinshasa, the Democratic Republic of Congo

TB and HIV in the Central African region: current knowledge and knowledge gaps

Development, coinfection, and the syndemics of pregnancy in Sub-Saharan Africa

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