Influence of 2', 5' oligoadenylates and theirs analogues on the cyclic nucleotides level in vivo and in vitro

Tkachuk, Z. Yu.; Tkachuk, V. V.; Tkachuk, L. V.; Semernikova, L. I.; Matsuka, G. Kh.

doi:10.7124/bc.0005cd

Cited by 4 publications

(2 citation statements)

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“…Considering the strong interrelationship and interdependence between 2'-5'-A and cAMP systems, we evaluated the association between the action of 2'-5'-A analogs upon cell cultures and animal organs, on one side, and concentrations of cAMP and cGMP in these cells and tissues, on the other side. Incubation of T-lymphocytes with 2'-5'-A 3 epoxy was shown to be associated with an increase of cAMP levels, while 2'-5'-A 3 decreased cAMP levels by approximately 2-fold [44].…”

Section: '-5'-a 3 Epoxy 2'-5'-a 3 Cord 2'-5'-a 3 Amino 2'-5'-a 3 Inomentioning

confidence: 87%

“…2'-5'-A 3 epoxy and 2'-5'-A 3 caused 2-2.5-fold lowering of cAMP, while cGMP level remained the same as it was in the liver. Therefore, 2'-5'-A 3 analogs, in contrast to natural 2'-5'-A 3 , when introduced into animal organs and tissues, influence the cAMP levels in a concentration-dependent manner, and do not affect the cGMP levels [44].…”

Section: '-5'-a 3 Epoxy 2'-5'-a 3 Cord 2'-5'-a 3 Amino 2'-5'-a 3 Inomentioning

confidence: 95%

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2'-5'-Oligoadenylates as a «tool» of innate immunity

Tkachuk

2013

Biopolym. Cell

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It is a matter of common knowledge, that «core» 2'-5'-oligoadenylates and their analogues posses broader biological activity than it can be predicted within the traditional «interferon» hypothesis. They exhibit immunomodulatory effects and are effective immunosuppressive agents upon organ and tissue transplantation. Oligoadenylates render antiviral activity against a wide range of viruses both DNA and RNA origin. These drugs regulate apoptosis, cell proliferation and possess antitumor activity. Such polyvalent activity is based on their ability to bind signaling proteins, slightly altering their conformation and modulating their activity. They can also change the secondary structure of both viral DNA and RNA, making them accessible for enzymatic cleavage. The hypothesis forwarded within this review is aimed at making an attempt to explain the mechanism of 2'-5'-oligoadenylates antiviral action. Our recent papers, containing experimental data to support this hypothesis, are discussed in this review

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Section: '-5'-a 3 Epoxy 2'-5'-a 3 Cord 2'-5'-a 3 Amino 2'-5'-a 3 Inomentioning

confidence: 87%

Section: '-5'-a 3 Epoxy 2'-5'-a 3 Cord 2'-5'-a 3 Amino 2'-5'-a 3 Inomentioning

confidence: 95%

2'-5'-Oligoadenylates as a «tool» of innate immunity

Tkachuk

2013

Biopolym. Cell

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Charge Transfer Model of Polar Clusters, Nature of Their Infinite-Range Interaction and Freezing Phenomena in PMN-Type Relaxors

Vikhnin

Blinc

Pirc

2002

Ferroelectrics Letters Section

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Synthesis of 2’-5’-oligoadenylates and study on their effect on proliferation and migration of bone marrow stem cells of mice in vitro and in vivo

et al. 2007

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Triadenylate and its 3'-ep oxy an a logue were syn the sized by phosphotriester method in so lu tion. These com pounds are shown to ac cel er ate the mi gra tion of the bone mar row stem cells in do nor mice and their in clu sion into the spleen of re cip i ent mice upon syngenic trans plan ta tion in vivo. 2'-5'-Oligoadenylates and their de riv a tives de pend ing on their struc ture and con cen tra tion in flu ence apoptosis and pro lif er a tion of mice bone mar row cells in vi tro.

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Influence of 2', 5' oligoadenylates and theirs analogues on the cyclic nucleotides level in vivo and in vitro

Cited by 4 publications

References 5 publications

2'-5'-Oligoadenylates as a «tool» of innate immunity

2'-5'-Oligoadenylates as a «tool» of innate immunity

Charge Transfer Model of Polar Clusters, Nature of Their Infinite-Range Interaction and Freezing Phenomena in PMN-Type Relaxors

Synthesis of 2’-5’-oligoadenylates and study on their effect on proliferation and migration of bone marrow stem cells of mice in vitro and in vivo

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