Influence of 2-Weeks Ingestion of High Chlorogenic Acid Coffee on Mood State, Performance, and Postexercise Inflammation and Oxidative Stress: A Randomized, Placebo-Controlled Trial

Abstract

This study measured the influence of 2-weeks ingestion of high chlorogenic acid (CQA) coffee on postexercise inflammation and oxidative stress, with secondary outcomes including performance and mood state. Cyclists (N = 15) were randomized to CQA coffee or placebo (300 ml/day) for 2 weeks, participated in a 50-km cycling time trial, and then crossed over to the opposite condition with a 2-week washout period. Blood samples were collected pre- and postsupplementation, and immediately postexercise. CQA coffee was prepared using the Turkish method with 30 g lightly roasted, highly ground Hambela coffee beans in 300 ml boiling water, and provided 1,066 mg CQA and 474 mg caffeine versus 187 mg CQA and 33 mg caffeine for placebo. Plasma caffeine was higher with CQA coffee versus placebo after 2-weeks (3.3-fold) and postexercise (21.0-fold) (interaction effect, p < .001). Higher ferric reducing ability of plasma (FRAP) levels were measured after exercise with CQA coffee versus placebo (p = .01). No differences between CQA coffee and placebo were found for postexercise increases in plasma IL-6 (p = .74) and hydroxyoctadecadienoic acids (9 + 13 HODEs) (p = .99). Total mood disturbance (TMD) scores were lower with CQA coffee versus placebo (p = .04). 50-km cycling time performance and power did not differ between trials, with heart rate and ventilation higher with CQA coffee, especially after 30 min. In summary, despite more favorable TMD scores with CQA coffee, these data do not support the chronic use of coffee highly concentrated with chlorogenic acids and caffeine in mitigating postexercise inflammation or oxidative stress or improving 50-km cycling performance.

Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review

“…This review outlined a wide assortment of ingredients, functional foods, and dietary supplements that have been shown to affect EIMD-related outcomes, with varying levels of success. In addition to the topics covered in the present review, many emergent nutritional and supplementation strategies have not been fully explored, including black tea-sourced polyphenols [161], blueberries [162], chondroitin sulfate [163], high chlorogenic acid coffee [164], fasting [165], garlic [166], leucine metabolites such as HICA [167], lemon verbena [168], lychee [169], mate tea [170], pequi fruit [171, 172], quercetin [173], saffron [174], selenium [175], sesame [176], spinach [177], and tomato juice [178, 179]. Future research in these nascent areas may shed new light on potential treatment options for EIMD.…”

Health Effects of Coffee: Mechanism Unraveled?

“…Cross-sectional studies of the level of circulating immune or inflammatory markers have reported small and not consistent variations in relation to habitual coffee consumption [24,25]. Randomized controlled trials of several weeks of coffee consumption in comparison to a water control were also performed and small reductions of some immune/inflammatory mediator concentrations were found, but the opposite was also reported [26][27][28][29][30]. Medium, but not dark roast coffee consumption increased the level of adiponectin [31].…”

The Acute Effects of Low-Dose Coffee Consumption on Anaerobic Performance in Adolescent Female Handball Players

“…68,69 Farklı formlarda hazırlanmış kahvenin performansa etkilerinin araştırıldığı çalışma örneklerinde Türk usulü hazırlanan kahvenin (3 mg/kg) 5 km performansında artış sağladığı, bunun aksine ise 2 haftalık düzenli Türk kahvesi tüketiminin (474 mg kafein), 50 km bisiklet performansına etkisinin olmadığı da belirtilmiştir. 70,71 Adölesan ve çocuklarda kafein tüketimi artmasına rağmen atletik performansa etkileriyle ilgili araştırmalar nispeten daha azdır. Adölesan ve çocuklarda yüksek doz kafein tüketimi erişkinler-dekine benzer etkilere neden olabileceği gibi, 10-12 yaş kız ve erkek çocuklarda kola ve enerji içeceği gibi yüksek kafein içerikli içeceklerin tüketimi de doz-yanıt ilişkisi çerçevesinde baş ağrısı, iştahsızlık, uyku problemleri ve mide ağrısına neden olabilir.…”