2022
DOI: 10.3390/ma15062091
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Influence of 3D Printing Parameters on the Mechanical Stability of PCL Scaffolds and the Proliferation Behavior of Bone Cells

Abstract: Introduction The use of scaffolds in tissue engineering is becoming increasingly important as solutions need to be found for the problem of preserving human tissue, such as bone or cartilage. In this work, scaffolds were printed from the biomaterial known as polycaprolactone (PCL) on a 3D Bioplotter. Both the external and internal geometry were varied to investigate their influence on mechanical stability and biocompatibility. Materials and Methods: An Envisiontec 3D Bioplotter was used to fabricate the scaffo… Show more

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Cited by 13 publications
(16 citation statements)
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“…Compared to this, the compressive strengths of our scaffolds were in a similar range to Mullah et al [ 17 ] between 5 and 25 MPa. In our other works [ 27 ], we also investigated the compressive strength of PCL scaffolds with different inner and outer geometries. They reached 91.4 ± 1.4 MPa and were even smaller dimensioned than the CPC scaffolds.…”
Section: Discussionmentioning
confidence: 99%
“…Compared to this, the compressive strengths of our scaffolds were in a similar range to Mullah et al [ 17 ] between 5 and 25 MPa. In our other works [ 27 ], we also investigated the compressive strength of PCL scaffolds with different inner and outer geometries. They reached 91.4 ± 1.4 MPa and were even smaller dimensioned than the CPC scaffolds.…”
Section: Discussionmentioning
confidence: 99%
“…Collagen coating in the present project was performed analogously to work we have already published [ 11 , 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…This captures both images of the surface and laser scans. Surface-specific values such as surface roughness (center roughness Sa) can then be measured, analogous to our previous work [ 11 , 14 ]. To investigate the surface roughness before and after plasma treatment of the scaffolds, images were acquired using the 3D laser microscope and the surface roughness was measured at four random locations.…”
Section: Methodsmentioning
confidence: 96%
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“…The results of 3D laser scanning microscopy to determine the surface roughness of the TC scaffolds showed slightly lower values of 2.15 ± 0.43 µm compared to our other studies of scaffolds printed with the 3D bioplotter. The studies of Weingartner et al [ 26 ] and Huber et al [ 27 ] on the effect of collagen I coatings of 3D printed PCL scaffolds for bone replacement determined a surface roughness of 4.11 ± 0.27 µm and 5.42 ± 0.82 µm for uncoated specimens and 3.35 ± 0.3 µm and 2.75 ± 0.48 µm for specimens coated with type I collagen. However, these were only coatings with collagen in the micrometre range and not scaffolds of collagen.…”
Section: Discussionmentioning
confidence: 99%