Influence of a Benzodiazepine Agonist and an Antagonist on Sleep-Eeg and the Nocturnal Prolactin Secretion

Preclinical data suggest that the imidazodiazepinone derivative bretazenil (Ro 16-6028) has anxiolytic and anticonvulsant properties with only weak sedative effects. We examined the influence of oral administration of 1 mg bretazenil on the sleep EEG and the concomitant nocturnal secretion of cortisol, growth hormone and prolactin in ten healthy young men. After bretazenil we found a significant increase in stage 2 sleep and a significant reduction in stage 3 sleep. REM latency was prolonged. Spectral analysis of sleep-EEG power revealed a decrease in delta and in theta power and an increase in sigma power. We found no significant influence on sleep onset latency or on intermittent wakefulness. Bretazenil prompted a significant decrease in cortisol secretion and a significant increase in prolactin release. It had no major influence on growth hormone secretion.

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Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men

Güldner

Trachsel

Kratschmayr

et al. 1995

Psychopharmacology

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Influence of a Benzodiazepine Agonist and an Antagonist on Sleep-Eeg and the Nocturnal Prolactin Secretion

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Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men

Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men

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