Influence of a Cocoa-Enriched Diet on the Intestinal Immune System and Microbiota

Camps-Bossacoma, Mariona; Massot-Cladera, Malén; Pérez-Cano, Francisco J.; Castell, Margarida

doi:10.1016/b978-0-12-814468-8.00018-1

Cited by 4 publications

(2 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individual foods can also correlate with specific inflammatory patterns and bacteria [33]. For example, coffee, tea, and berries encourage Oscillibacter as well as anti-inflammatory pathways; red wine can induce beneficial changes in the microbiome [40]; the consumption of fish is associated with SCFA production [41]; and the consumption of chocolate is associated with changes in the microbiome and SCFA increases [42,43].…”

Section: Influences On the Microbiomementioning

confidence: 99%

Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome

Bicknell

Liebert

Borody

et al. 2023

IJMS

View full text Add to dashboard Cite

The human gut microbiome contains the largest number of bacteria in the body and has the potential to greatly influence metabolism, not only locally but also systemically. There is an established link between a healthy, balanced, and diverse microbiome and overall health. When the gut microbiome becomes unbalanced (dysbiosis) through dietary changes, medication use, lifestyle choices, environmental factors, and ageing, this has a profound effect on our health and is linked to many diseases, including lifestyle diseases, metabolic diseases, inflammatory diseases, and neurological diseases. While this link in humans is largely an association of dysbiosis with disease, in animal models, a causative link can be demonstrated. The link between the gut and the brain is particularly important in maintaining brain health, with a strong association between dysbiosis in the gut and neurodegenerative and neurodevelopmental diseases. This link suggests not only that the gut microbiota composition can be used to make an early diagnosis of neurodegenerative and neurodevelopmental diseases but also that modifying the gut microbiome to influence the microbiome–gut–brain axis might present a therapeutic target for diseases that have proved intractable, with the aim of altering the trajectory of neurodegenerative and neurodevelopmental diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, autism spectrum disorder, and attention-deficit hyperactivity disorder, among others. There is also a microbiome–gut–brain link to other potentially reversible neurological diseases, such as migraine, post-operative cognitive dysfunction, and long COVID, which might be considered models of therapy for neurodegenerative disease. The role of traditional methods in altering the microbiome, as well as newer, more novel treatments such as faecal microbiome transplants and photobiomodulation, are discussed.

show abstract

Section: Influences On the Microbiomementioning

confidence: 99%

Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome

Bicknell

Liebert

Borody

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Besides the influence on cardiovascular and nervous systems, we have demonstrated the anti-inflammatory and immunomodulatory properties of cocoa-enriched diets [ 10 , 18 , 19 ]. In this regard, a flavonoid-enriched cocoa extract was able to decrease, in vitro, the secretion of inflammatory mediators such as TNF-α, monocyte chemoattractant protein-1 and nitric oxide (NO) by macrophages [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Consumption of Two Peruvian Cocoa Populations on Mucosal and Systemic Immune Response in an Allergic Asthma Rat Model

et al. 2022

Self Cite

View full text Add to dashboard Cite

Different cocoa populations have demonstrated a protective role in a rat model of allergic asthma by attenuating the immunoglobulin (Ig) E synthesis and partially protecting against anaphylactic response. The aim of this study was to ascertain the effect of diets containing two native Peruvian cocoa populations (“Amazonas Peru” or APC, and “Criollo de Montaña” or CMC) and an ordinary cocoa (OC) on the bronchial compartment and the systemic and mucosal immune system in the same rat model of allergic asthma. Among other variables, cells and IgA content in the bronchoalveolar lavage fluid (BALF) and serum anti-allergen antibody response were analyzed. The three cocoa populations prevented the increase of the serum specific IgG1 (T helper 2 isotype). The three cocoa diets decreased asthma-induced granulocyte increase in the BALF, which was mainly due to the reduction in the proportion of eosinophils. Moreover, both the OC and CMC diets were able to prevent the leukocyte infiltration caused by asthma induction in both the trachea and nasal cavity and decreased the IgA in both fecal and BALF samples. Overall, these results highlight the potential of different cocoa populations in the prevention of allergic asthma.

show abstract

Pemberdayaan Kelompok Tani dalam Pemanfaatan Kulit Buah Kakao (Theobroma Cacao L.) sebagai Produk Suplemen Antioksidan

Oktoba

Adjeng²,

Sangging³

et al. 2023

JPMWP

View full text Add to dashboard Cite

Pemanfaatan limbah kulit buah kakao (Theobroma cacao L.) menjadi produk suplemen kesehatan antioksidan berupa sediaan kapsul. Kegiatan pengabdian kepada masyarakat bertujuan untuk mengenalkan bahwa limbah KBK yang dibuang oleh petani berupa cangkang menjadi limbah perkebunan yang tidak termanfaatkan dan menjadi sumber pencemaran. Senyawa fenolik sebagai antioksidan dari limbah KBK berkhasiat menghambat aktivitas radikal bebas pada tubuh manusia. Kandungan 6 – 9% protein kasar dari KBK telah dimanfaatkan dengan baik sebagai produk suplemen herbal antioksidan. Kegiatan ini dilakukan pada bulan Agustus 2022 yang merupakan bagian program pengabdian masyarakat unggulan Universitas Lampung. Pemanfaatan KBK sebagai produk kapsul suplemen herbal antioksidan, menciptakan kondisi lahan perkebunan kakao menjadi bersih, terhindar dari penyakit seperti busuk buah serta mengendalikan serangan hama. Pelaksanaan PKM bertujuan untuk meningkatkan kapasitas kesejahteraan dan kapasitas masyarakat kelompok tani kakao Pekondoh. Melalui dukungan pemanfaatan serta pemberdayaan potensi sumber daya pekon (desa) dengan cara penyuluhan pembuatan produk sediaan kapsul suplemen antioksidan dari limbah KBK. Hasil pelaksanaan PKM telah diterapkan dengan baik dengan memanfaatkan limbah KBK menjadi produk olahan sediaan kapsul WAKLATDO®. Pengetahuan serta pemahaman masarakat sebelum dan setelah terlibat dalam kegiatan pengabdian berbeda cukup signifikan. Pemanfatan KBK sebelum pendampingan (pre-test) adalah 27.33% dan setelah (post-test) adalah 80,12%. Hasil dapat dikatakan bahwa kegiatan pengabdian yang dilakukan cukup membawa dampak baik akan pengetahuan dalam pemanfaatn KBK.

show abstract

Influence of a Cocoa-Enriched Diet on the Intestinal Immune System and Microbiota

Cited by 4 publications

References 78 publications

Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome

Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome

Influence of Consumption of Two Peruvian Cocoa Populations on Mucosal and Systemic Immune Response in an Allergic Asthma Rat Model

Pemberdayaan Kelompok Tani dalam Pemanfaatan Kulit Buah Kakao (Theobroma Cacao L.) sebagai Produk Suplemen Antioksidan

Contact Info

Product

Resources

About