Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status, choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague–Dawley rats

Donahue, Douglas A.; Dougherty, Edward J.; Meserve, Lee A.

doi:10.1016/j.tox.2004.06.011

Cited by 50 publications

(24 citation statements)

References 19 publications

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“…Exposure of adult mice and rats to PBDE-47 or to the pentaBDE mixture, Bromkal 70-5DE, decreased serum total and free T 4 levels, without altering thyrotropin (TSH) levels (Hallgren and Darnerud, 2002;Hallgren et al, 2001). Previous studies have demonstrated a dose-dependent depression of thyroid hormones in response to concentrations of a complex PCBs mixture (Donahue et al, 2004). The concentration of T 4 in serum is also reduced in rats exposed to PCBs (Hood and Klaassen, 2000).…”

Section: Discussionmentioning

confidence: 98%

Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats

Wang

Niu

et al. 2010

Toxicol Ind Health

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Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are widespread environmental contaminants. There are potential interactive effects between PBDEs and PCBs, as these compounds share similar structures. The developmental neurotoxicity of 2, 2', 4, 4'-tetrabromodiphenyl ether (PBDE-47) and the interaction of PBDE-47 with 2, 2', 4, 4', 5, 5'-hexachlorobipheny (PCB153) were investigated herein, as the dominant congener forms of PBDEs and PCBs, respectively. SD rats were exposed to a single oral dose of PBDE-47 (1, 5, and 10 μg/g) and/or PCB153 (5 μg/g) on post-natal day (PND) 10. Concentrations of PBDE-47, triiodothyronine (T(3)), thyroxine (T(4)), and thyroid-stimulating hormone (TSH) in serum; organ-to-body weight ratios; as well as long-term learning and memory were measured in 2-month-old rats. The present study found that some doses of PBDE-47 decreased the organ-to-body weight ratios of the thyroid and uterus, decreased the concentration of T(4) in serum, and increased the organ-to-body weight ratio of the ovaries (p < 0.05). PCB153 could increase the action of PBDE-47 during combined exposure, but this interaction was not found between PBDE-47 and PCB153. In a Morris water maze experiment, the latency periods were significantly prolonged and time ratios were obviously depressed in all PBDE-47-treated groups compared to the control (p < 0.05); furthermore, significant interactions between PBDE-47 and PCB153 were observed (p < 0.05). In conclusion, PBDE-47 may depress thyroid development as well as the long-term learning and memory capabilities in adult rats exposed to PBDE-47 on PND 10. PCB153 can interact with PBDE-47, resulting in an increase in developmental neurotoxicity.

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Section: Discussionmentioning

confidence: 98%

Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats

Wang

Niu

et al. 2010

Toxicol Ind Health

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“…PCP decreased the plasma T4 levels in rats (BruckerDavis, 1998;Kawaguchi et al, 2008). Decreased T4 levels are frequently observed in mammals, amphibian and fish models exposed to TH endocrine disruptors, e.g., PBDEs (Tomy et al, 2004;Ellis-Hutchings et al, 2006;Lema et al, 2008;Yu et al, 2010), PCBs (Donahue et al, 2004;Martin and Klaassen, 2010;Schnitzler et al, 2011), and perchlorates (Mukhi and Patino, 2007;Opitz et al, 2009;Schmidt et al, 2012). Decreased TT4 and increased TT3 levels and the consequent increased ratio of T3/T4 are frequently observed in fish exposed to TH endocrine disruptors (Chen et al, 2012;Wang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Thyroid endocrine system disruption by pentachlorophenol: An in vitro and in vivo assay

Guo

Zhou

2013

Aquatic Toxicology

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“…High blood levels of POPs, including HCB, oxychlordane, DDT metabolites, and PCBs, have been associated with a decrease in viable offspring, a decrease in adult yearly survival rate, and an increase in wing feather asymmetry (Bustnes et al, 2002(Bustnes et al, , 2003Kuenzel, 2003;Leeson and Walsh, 2004). Thyroid hormone deficits during early life stages affect neurodevelopment and subsequent behavior and cognitive ability in vertebrates (Donahue et al, 2004;Jenssen, 2006). Studies of polar bears have shown disrupted thyroid hormone homeostasis induced by POP exposures (Norstrom, 2000;Skaare et al, 2001;Wiig, 1995).…”

Section: Altered Ecosystemsmentioning

confidence: 99%

The toxicology of climate change: Environmental contaminants in a warming world

Noyes

McElwee

Miller

et al. 2009

Environment International

970

569

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Climate change induced by anthropogenic warming of the earth's atmosphere is a daunting problem. This review examines one of the consequences of climate change that has only recently attracted attention: namely, the effects of climate change on the environmental distribution and toxicity of chemical pollutants. A review was undertaken of the scientific literature (original research articles, reviews, government and intergovernmental reports) focusing on the interactions of toxicants with the environmental parameters, temperature, precipitation, and salinity, as altered by climate change. Three broad classes of chemical toxicants of global significance were the focus: air pollutants, persistent organic pollutants (POPs), including some organochlorine pesticides, and other classes of pesticides. Generally, increases in temperature will enhance the toxicity of contaminants and increase concentrations of tropospheric ozone regionally, but will also likely increase rates of chemical degradation. While further research is needed, climate change coupled with air pollutant exposures may have potentially serious adverse consequences for human health in urban and polluted regions. Climate change producing alterations in: food webs, lipid dynamics, ice and snow melt, and organic carbon cycling could result in increased POP levels in water, soil, and biota. There is also compelling evidence that increasing temperatures could be deleterious to pollutant-exposed wildlife. For example, elevated water temperatures may alter the biotransformation of contaminants to more bioactive metabolites and impair homeostasis. The complex interactions between climate change and pollutants may be particularly problematic for species living at the edge of their physiological tolerance range where acclimation capacity may be limited. In addition to temperature increases, regional precipitation patterns are projected to be altered with climate change. Regions subject to decreases in precipitation may experience enhanced volatilization of POPs and pesticides to the atmosphere. Reduced precipitation will also increase air pollution in urbanized regions resulting in negative health effects, which may be exacerbated by temperature increases. Regions subject to increased precipitation will have lower levels of air pollution, but will likely experience enhanced surface deposition of airborne POPs and increased run-off of pesticides. Moreover, increases in the intensity and frequency of storm events linked to climate change could lead to more severe episodes of chemical contamination of water bodies and surrounding watersheds. Changes in salinity may affect aquatic organisms as an independent stressor as well as by altering the bioavailability and in some instances increasing the toxicity of chemicals. A paramount issue will be to identify species and populations especially vulnerable to climate-pollutant interactions, in the context of the many other physical, chemical, and biological stressors that will be altered with climate change. Moreover, it w...

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Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status, choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague–Dawley rats

Cited by 50 publications

References 19 publications

Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats

Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats

Thyroid endocrine system disruption by pentachlorophenol: An in vitro and in vivo assay

The toxicology of climate change: Environmental contaminants in a warming world

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