Influence of a hydrophobic diol on the micellar transitions of Pluronic P85 in aqueous solution

Bharatiya, Bhavesh; Aswal, Vinod K.; Hassan, P. A.; Bahadur, Pratap

doi:10.1016/j.jcis.2008.01.050

Cited by 22 publications

(9 citation statements)

References 45 publications

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“…The CMC values are 45, 60, and 120 mg l −1 for RL-F2, RL-F1, and the crude extracted mixture, respectively, which are in good agreement with the literature values (10 to 230 mg l −1 ) [1]. Theoretically, molecules with higher hydrophobicity are more prone to aggregate as micelles at a lower concentration [30]. However, in this study, the CMC value of the RL-F2 fraction was repeatedly found to be lower than that of RL-F1.…”

Section: Micellization Behaviors Of Rl-f1 Rl-f2 and Crude Extractssupporting

confidence: 88%

“…This is unexpectedly in line with previous findings from the CMC experiment. The increase of a hydrophobic core [30] and more effectively staggered array of alternating molecules with mono-or di-rhamnosyl moieties [14,29] in micelle for such multi-components of a di-rhamnolipid/monorhamnolipid/fatty acid system are mostly to favor the formation of much larger aggregates.…”

Section: Micellization Behaviors Of Rl-f1 Rl-f2 and Crude Extractsmentioning

confidence: 99%

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Characterization and micellization of rhamnolipidic fractions and crude extracts produced by Pseudomonas aeruginosa mutant MIG-N146

Guo

et al. 2009

Journal of Colloid and Interface Science

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Section: Micellization Behaviors Of Rl-f1 Rl-f2 and Crude Extractssupporting

confidence: 88%

Section: Micellization Behaviors Of Rl-f1 Rl-f2 and Crude Extractsmentioning

confidence: 99%

Characterization and micellization of rhamnolipidic fractions and crude extracts produced by Pseudomonas aeruginosa mutant MIG-N146

Guo

et al. 2009

Journal of Colloid and Interface Science

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“…Some reports on oil solubilization are available and clearly mention that the Pluronic micelles undergo remarkable phase transition under the effect of oils [49]. Previous studies on the effect of various alkanols [50], salts [51], diols [52] on TBCP micelles have shown similar results indicating that the micellar growth is not restricted to the partitioning of only aromatic oils.…”

Section: Cmts and Micellar Size Of Copolymers In Watermentioning

confidence: 84%

“…The aggregation number increased on solubilization though the micelles remained spherical. The addition of oils dehydrates the PEO shells and induces the hydrophobicity in the PPO block [52,55]. The radius of gyration of the polymer segment does not show any change in presence of additives, it has been kept fixed (14 Ǻ ).…”

Section: Cmts and Micellar Size Of Copolymers In Watermentioning

confidence: 99%

Solubilization of Aromatic Hydrocarbons in Ethylene Oxide‐Propylene Oxide Triblock Micelles: Location of Solubilizate and its Effect on Micelle Size from 2D NMR and Scattering Techniques

Parekh

Singh²,

Marangoni³

et al. 2011

J Surfact & Detergents

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The solubilization of benzene and toluene in micellar solutions and the effects on the micellization and micelle size of ethylene oxide-propylene oxide triblock copolymers were investigated by dynamic light scattering (DLS), small angle neutron scattering (SANS), and 2D NMR spectroscopy. The copolymeric surfactants have the same size as the middle hydrophobic polypropylene oxide block (Mol. Wt. 3250) and varying polyethylene oxide end blocks (30, 40 and 50%). The solubilization and the properties of the micelles in the presence of the solubilizates were investigated; the results reveal that the more hydrophobic copolymer showed better solubilization. The cloud points of the copolymers decreased in the presence of oils; the depression in the cloud point is due to the formation of an electron donor-acceptor complex. DLS shows that the effect of benzene is dominated at high oil concentration. SANS data show that the micelles remain spherical in shape and that the micellar core size does not change with higher benzene concentration; observed changes in the low scattering vector region could be because of some small amount of benzene clusters formed at higher benzene concentration. Finally, the locus of solubilization of the oils in the copolymer micelles was determined via 2D NMR experiments. In all cases, significant nuclear Overhauser effect spectroscopy (NOESY) cross peaks were observed that appeared to correlate well with the expected loci of these solubilizates in micelles. Hence, the noninvasive NOESY technique provides important information on the location of the aromatic solubilizates in these copolymer micelles that depends on the structure of the oils.

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“…Interestingly, LepNP85 had lower polydispersity and less aggregation than native leptin. Each sample exhibited a main fraction of small particles with an effective diameter of 5.3 nm for leptin and 8.2 nm for LepNP85, which is much smaller than the typical diameter of P85 micelles (around 16 nm [47]).…”

Section: Resultsmentioning

confidence: 99%

Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity

Yuan

Xiang

Zhao

et al. 2017

Journal of Controlled Release

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Leptin is an adipocyte-secreted hormone that is delivered via a specific transport system across the blood-brain barrier (BBB) to the brain where it acts on the hypothalamus receptors to control appetite and thermogenesis. Peripheral resistance to leptin due to its impaired brain delivery prevents therapeutic use of leptin in overweight and moderately obese patients. To address this problem, we modified the N-terminal amine of leptin with Pluronic P85 (LepNP85) and administered this conjugate intranasally using the nose-to-brain (INB) route to bypass the BBB. We compared this conjugate with the native leptin, the N-terminal leptin conjugate with poly(ethylene glycol) (LepNPEG5K), and two conjugates of leptin with Pluronic P85 attached randomly to the lysine amino groups of the hormone. Compared to the random conjugates of leptin with P85, LepNP85 has shown higher affinity upon binding with the leptin receptor, and similarly to native hormone activated hypothalamus receptors after direct injection into brain. After INB delivery, LepNP85 conjugate was transported to the brain and accumulated in the hypothalamus and hippocampus to a greater extent than the native leptin and LepNPEG5K and activated leptin receptors in hypothalamus at lower dose than native leptin. Our work suggests that LepNP85 can access the brain directly after INB delivery and confirms our hypothesis that the improvement in brain accumulation of this conjugate is due to its enhanced brain absorption. In conclusion, the LepNP85 with optimized conjugation chemistry is a promising candidate for treatment of obesity.

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Influence of a hydrophobic diol on the micellar transitions of Pluronic P85 in aqueous solution

Cited by 22 publications

References 45 publications

Characterization and micellization of rhamnolipidic fractions and crude extracts produced by Pseudomonas aeruginosa mutant MIG-N146

Characterization and micellization of rhamnolipidic fractions and crude extracts produced by Pseudomonas aeruginosa mutant MIG-N146

Solubilization of Aromatic Hydrocarbons in Ethylene Oxide‐Propylene Oxide Triblock Micelles: Location of Solubilizate and its Effect on Micelle Size from 2D NMR and Scattering Techniques

Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity

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