Influence of a long-acting somatostatin analogue (SMS 201–995) in acromegalic patients

Effect of a single administration of somatostatin analogue (SMS 201-995) on GH, TSH and insulin secretion in patients with acromegaly.

“…This analogue was reported to show less rebound hypersecretion of GH (Althoff et al, 1984;Ch'ng et al, 1985 ;Mayer and Tillil, 1984 ;Lamberts et al, 1985 a, b ;Plewe et al, 1984 a, b 1985;Kraenzlin et al, 1985;Schulter et al, 1983;Spinas et al, 1984).…”

The effect of minisomatostatin on anomalous growth hormone responses in acromegaly

“…With the development of the long-acting somatostatin ana¬ logue SMS 201-995 (minisomatostatin, SMS) it became possible to normalize the GH levels in the majority of patients with acromegaly (Bauer et al 1982;von Werder et al 1984;Plewe et al 1984;Ch'ng et al 1985;Althoff et al 1984;Lamberts et al 1985Lamberts et al , 1986Pieters et al 1986). We studied the effects of 4 weeks of treatment with SMS on the GH responses to glucose loading, TRH, LRH and GHRH administration in 12 patients with acro¬ megaly.…”