Influence of a low-calorie diet with inclusion of a specialised food product with modified carbohydrate profile on the parameters of glycaemic variability in patients with diabetes mellitus type 2

Шарафетдинов, Х Х; Плотникова, О А; Alekseeva, R I; Nazarova, A.M.; Sasunova, Armida; Pilipenko, V.V.; Кондратьева, О В

doi:10.20953/2224-5448-2019-3-16-21

Cited by 2 publications

(2 citation statements)

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“…The dried skimmed milk (GI 45), dried whole milk (GI 32), dried milk whey (GI 43), and dried permeate (GI 41) may be referred to such ingredients; their main component is carbohydrate of the animal origin, lactose, which is characterized by glycemic index of 46 and sweetness coefficient of 0.4 regarding sucrose [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Sucrose, Lactose, Thermogravimetry, and Differential Thermal Analysis: The Estimation of the Moisture Bond Types in Lactose-Containing Ingredients for Confectionery Products with Reduced Glycemic Index

Melnikova,

Bogdanova,

Paveleva

et al. 2023

International Journal of Food Science

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This research is aimed at conducting a comparative analysis of the dehydration process of lactose-containing ingredients and sucrose. Differential scanning calorimetry (DSC) and thermogravimetry (TG) methods were used to investigate the moisture bond types and the process of thermal degradation in native whey, dried skimmed milk, dried whole milk, dried milk whey demineralized, purified lactose, and sucrose. There were several peaks on the DSC and TG curves for lactose-containing ingredients. They determine the loss of the physically absorbed water on surfaces, physically occluded water and hydrate-forming water (up to 180°C), anomerization of lactose (160–220°C), and melting followed by decomposition (above 230°C). The multiple peaks on the dDSC curves from 135 to 170°C indicate the course of the Maillard reaction in the mix with proteins. For the native whey, the amount of chemically bound water was 56.11 ± 1 %; for the dried whole milk, it was 59.86 ± 1 %; for the milk whey demineralized, it was 64.56 ± 1 %; and for the dried skimmed milk, it was 67.17 ± 1 %. The results are presented as mean values ± SD ( n = 3 ) and were considered statistically significant when P < 0.05 . The similar to some extent form of the DSC and TG curves to lactose-containing ingredients and granulated sugar confirms the possibility of using them as the component of bakery and confectionery product formulas to reduce the glycemic index and improve organoleptic properties of products as well as correct their mineral compositions. Considering the constant changing of technologies for obtaining various dairy ingredients as well as the occurrence of their new kinds, such studies contribute to the expansion of existing knowledge and reference data.

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Section: Introductionmentioning

confidence: 99%

Sucrose, Lactose, Thermogravimetry, and Differential Thermal Analysis: The Estimation of the Moisture Bond Types in Lactose-Containing Ingredients for Confectionery Products with Reduced Glycemic Index

Melnikova,

Bogdanova,

Paveleva

et al. 2023

International Journal of Food Science

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“…These studies also demonstrated the use of pectin in applications such as coronary heart disease due to hypercholesterolemia and ischemic heart disease through its effect on platelet aggregation and blood clotting, type II diabetes, satiety, and obesity (Lorenzo et al, 1989;Savastano et al, 2014;Cerda et al, 1988;Challen et al, 1983;Asp et al, 1981;Sharafetdinov et al, 1993;Howarth et al, 2003;Liebermeister & Toluipur, 1980).…”

Section: Pectin's In Clinical Studiesmentioning

confidence: 96%

Evaluation of MCP anticancer activity using molecular imaging

Silva

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MCP is a polysaccharide found abundantly in the plant's primary wall and shows activity in several areas of the food industry and nutrition, serving in food production, improving intestinal flow, reducing cholesterol, and being an important nutritional compound. MCP can also act as an anti-tumorigenic molecule in several types of tumors, in addition to avoiding chemoresistance, modulating the immune system, and preventing renal disease caused by radiotherapy and chemotherapy in cancer treatments. This study was divided into three main parts. In the first part, a review was carried out to study the biological activity of MCP and its contribution to cancer therapy, demonstrating treatment doses, types of MCP used, and experimental design, providing a critical view of the exposed data and its relationship with galectin-3 and other theories regarding its mechanisms. In the second part, we radiolabeled MCP with 99m Tc and verified the biodistribution and pharmacokinetics of MCP-99m Tc orally and intravenously (IV) administrated. First, the structure and monosaccharide composition of MCP were studied, and it was demonstrated that there is a diversity of monosaccharides and molecular weights within the MCP structure and that MCP30 and MCP3 fractions are rich in galactose. Next, we studied the inhibition and binding affinity of MCP for galectin-3 and demonstrated that MCP partially binds Gal-3 and that MCP3 shows an inhibition capacity at a concentration of 25 mg/ml. We radiolabeled MCP with 99m Tc and verified its stability in saline in different pH, plasma, and in vivo. MCP-99m Tc has a low gastrointestinal absorption (5.27x10-6 % total radioactivity counts) and gastrointestinal elimination when administered via oral and renal and hepatobiliary elimination when administered via IV. Finally, the blood compartment distribution assay showed that MCP-99m Tc has a high affinity for plasma proteins and blood cells in C57BL/6 Lgals3 +/+ mice, and this affinity was partially lost when galectin-3 was deleted in C57BL/6 Lgals3 -/mice.The pharmacokinetic assay showed that MCP-99m Tc elimination speed was greater in the C57BL/6 Lgals3 -/mice than in the C57BL/6 Lgals3 +/+ , indicating that a lack of galectin-3 increases MCP elimination. In the third part, we analyzed the behavior of MCP-99m Tc in 8 animals with SKOV-3 and MKN45 tumors using molecular imaging. First, we demonstrated that cell binding and internalization of MCP were only partially influenced by Galectin-3 expression in vitro using SKOV-3 scrambled and SKOV-3 shRNAGal3 cells (knockdown of Gal-3 expression). Next, we showed that MCP (20 mg/kg) exhibited anticancer activity in a SKOV-3 cell tumor xenograft model, reducing tumor growth by 48.5% and tumor weight by 50% when administered intravenously; however, oral administration of MCP (200 mg/kg) did not show an anticancer effect. Subsequently, we demonstrated that MCP-99m Tc reached the tumor and bound to regions of necrosis in the SKOV-3 cell tumor xenograft model when administered intravenously. Finally, we demonstr...

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Influence of a low-calorie diet with inclusion of a specialised food product with modified carbohydrate profile on the parameters of glycaemic variability in patients with diabetes mellitus type 2

Cited by 2 publications

References 0 publications

Sucrose, Lactose, Thermogravimetry, and Differential Thermal Analysis: The Estimation of the Moisture Bond Types in Lactose-Containing Ingredients for Confectionery Products with Reduced Glycemic Index

Sucrose, Lactose, Thermogravimetry, and Differential Thermal Analysis: The Estimation of the Moisture Bond Types in Lactose-Containing Ingredients for Confectionery Products with Reduced Glycemic Index

Evaluation of MCP anticancer activity using molecular imaging

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