Influence of a Novel Food-Grade Formulation of Red Chili Extract (<i>Capsicum annum</i>) on Overweight Subjects: Randomized, Double-Blinded, Placebo-Controlled Study

Joseph, Ashil; John, Febi; Thomas, Jestin V.; Sivadasan, Syam Das; Maliakel, Balu; Mohan, Ratheesh; Krishnakumar, I. M.

doi:10.1080/19390211.2020.1780363

Cited by 6 publications

(8 citation statements)

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“…This was achieved using a proprietary hydrogel technology known as FenuMat® ( 20 ). The microbeadlets known as Capsifen® (CapF) are bioavailable and safe at dosages of 200 mg/day in individuals with obesity and helped to reduce body weight following 28 days of supplementation ( 21 ). However, it is unknown whether lower dosages are efficacious for supporting weight management.…”

Section: Introductionmentioning

confidence: 99%

A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study

Roopashree,

Syam,

Krishnakumar

et al. 2024

Front. Nutr.

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IntroductionOverweight and obesity are major public health concerns, with a sharp increase in prevalence over the last few decades. The primary cause is an imbalance between calorie intake and expenditure due to a rise in calorie-rich processed food and reduced physical activity. Energy balance in humans involves complex processes including thermogenesis, a crucial factor in regulating energy expenditure.MethodsIn this randomized, double-blinded, placebo-controlled three-arm three-sequence study, we investigated the efficacy of Capsifen® (CapF), a pungency-masked sustained-intestinal release formulation of red chili extract, on energy expenditure, fat oxidation, and endurance using the Quark C-PET system in healthy overweight participants, with and without exercise. In the study, 105 healthy participants were randomized to receive either placebo, CapF 100 mg/day, or CapF 200 mg/day for 28 days.ResultsCapF demonstrated a dose-dependent response to increased energy expenditure and fatty acid oxidation with a concomitant reduction in body weight. Both CapF 100 and CapF 200 also increased the time to exhaustion.DiscussionThese results demonstrate the plausible efficacy of CapF in energy expenditure and physical performance in otherwise healthy adults who have a high body mass index.Clinical trial registrationhttps://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjQzNTg=&Enc=&userName=CTRI/2018/04/013157 dated 04 October 2018.

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Section: Introductionmentioning

confidence: 99%

A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study

Roopashree,

Syam,

Krishnakumar

et al. 2024

Front. Nutr.

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“…The articles included in this study were published between 1998 and 2021, spanning five continents in ten different countries, including Asia (26)(27)(28)(29)(30)(31)(32), Europe (33,34), Australia / Oceania (10), and North America (35)(36)(37)(38), South America (36), with the sample size ranging from 20 to 123. The detailed characteristics of the included studies were demonstrated in https://doi.org/10.1017/S0007114523000697 Published online by Cambridge University Press Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…All of the included studies used parallel designs. One study was conducted in female only (31) , another was conducted in the male participants only (26) and the rest of the studies were completed in both sexes. Nine studies were carried out in overweight individuals (10,(26)(27)(28)(29)(30)32,33,38) , while one study did not report BMI data and the rest were carried out in obese individuals.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…One study was conducted in female only (31) , another was conducted in the male participants only (26) and the rest of the studies were completed in both sexes. Nine studies were carried out in overweight individuals (10,(26)(27)(28)(29)(30)32,33,38) , while one study did not report BMI data and the rest were carried out in obese individuals. The intervention time of capsaicin supplementation ranged from 4 to 12 weeks, nine of which took capsaicin, and the rest took active supplements containing capsaicin (Table 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In stratified analyses by region (Asia v. others), ingestion form (capsaicin v. active supplement), duration of study (4 weeks v. 6-12 weeks) or body type (overweight v. obese), capsaicin supplementation had none significant decrease on WHR (Table 2). Hoeger (35) 1998 America 123 56/67 4 Take an over-the-counter dietary supplement/take placebo supplement Capsaicin 35•3 ± 6•0/ 32•8 ± 5•5 Ashil Joseph (26) 2021 Vogel (38) 2015 America 2).…”

Section: Effect Of Capsaicin Supplementation On Waist-to-hip Ratiomentioning

confidence: 99%

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The effects of capsaicin intake on weight loss among overweight and obese subjects: a systematic review and meta-analysis of randomised controlled trials

et al. 2023

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Animal studies have shown that capsaicin plays a positive role in weight management. However, the results in human research are controversial. Therefore, the present systematic review and meta-analysis aimed to evaluate the effect of capsaicin on weight loss in adults. We searched PubMed, Embase, China Biomedical Literature Database (CBM), Cochrane library and clinical registration center, identifying all randomized controlled trials (RCTs) published in English and Chinese to May 3, 2022. A random effect model was used to calculate the weighted mean difference (WMD) and 95% confidence interval (CI). Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I 2 ). Statistical analyses were performed using STATA version 15.1. P <0.05 were considered as statistically significant. From 2377 retrieved studies, 15 studies were finally included in the meta-analyses. Fifteen RCTs with 762 individuals were included in our meta-analysis. Compared with the control group, the supplementation of capsaicin resulted in significant reduction on body mass index (BMI) (WMD: -0.25 kg/m2, 95%CI=-0.35∼-0.15 kg/m2, P<0.05), body weight (BW) (WMD: -0.51 kg, 95%CI=-0.86∼-0.15 kg, P<0.05) and waist circumference (WC) (WMD: -1.12 cm, 95%CI=-2.00∼-0.24 cm, P<0.05). We found no detrimental effect of capsaicin on waist-to-hip ratio (WHR) (WMD: -0.05, 95%CI=-0.17∼0.06, P>0.05). The current meta-analysis suggests that capsaicin supplementation may have rather modest effects in reducing BMI, BW and WC for overweight or obese individuals.

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Aerobic Exercise Training Under Normobaric Hypoxic Conditions to Improve Glucose and Lipid Metabolism in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis

Guo,

Cheng,

Duolikun

et al. 2023

High Altitude Medicine & Biology

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Influence of a Novel Food-Grade Formulation of Red Chili Extract (Capsicum annum) on Overweight Subjects: Randomized, Double-Blinded, Placebo-Controlled Study

Cited by 6 publications

References 48 publications

A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study

A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study

The effects of capsaicin intake on weight loss among overweight and obese subjects: a systematic review and meta-analysis of randomised controlled trials

Aerobic Exercise Training Under Normobaric Hypoxic Conditions to Improve Glucose and Lipid Metabolism in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis

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