Influence of a Polyneurotransmitter on DNA-Mediated Förster-Based Resonance Energy Transfer: A Path Leading to White Light Generation

Abstract

The physiologically important biomolecule, dopamine (DA), shows strong self-oxidation and aggregation behaviors, which have been controlled and modulated to result in fluorescent polydopamine (F-PDA) nanoparticles. On the other hand, the simultaneous binding of two diverse deoxyribonucleic acid (DNA) binding probes, 4′,6-diamidino-2-phenylindole dihydrochloride (DAPI) and ethidium bromide (EtBr), has been elaborately established to follow the Forsterbased resonance energy transfer (FRET) pathway. The comparative understanding of this DNA-mediated FRET in three media, phosphate buffer saline (PBS) of pH 7.4, DA, and F-PDA, has concluded that the FRET efficiency in the three media follows the order: PBS > DA > F-PDA. This controlled FRET in the fluorescent F-PDA matrix serves a pivotal role for efficient white light (WL) generation with excellent Commission Internationale de l'Eclairage (CIE) parameters that match well with that of pure WL emission. The obtained WL emission has been shown to be very specific with respect to concentrations of different participating components and the excitation wavelength of the illuminating source. Furthermore, the optical properties of the WL emitting solution have been observed to be retained excellently inside the well-known agarose gel matrix. Finally, the mechanistic pathway behind such a FRET-based WL generation has been established in detail, and to the best of our knowledge, the current study offers the first and only report that discloses the influence of a fluorescent polyneurotransmitter matrix for successful generation of WL emission.

Ultrafast Dynamics of the Medicinal Pigment Curcumin inside the Imidazolium Surface Active Ionic Liquid Containing Giant Vesicles and White Light Generation via Triple-FRET Technique

“…In the [C 16 mim]Cl micellar solution, the CIE coordinate is (0.32, 0.35), which is close to the CIE coordinate (0.33, 0.33) of a pure WL system (Figure ). The CIE coordinates in Span 20 and Span 80 containing giant vesicles are (0.33, 0.37) and (0.33, 0.38), respectively (Figure ) and fall in the white light region. , Now, in addition to the CIE coordinates, the color rendering index (CRI) and correlated color temperature (CCT) are additional parameters that ensure the generation of efficient WL. Table provides the calculated CRI and CCT values for all of these systems.…”

“…The CRI values in the micellar and the vesicular systems are between 73 and 85, satisfying the WL generation condition (∼80), and the CCT values are within 5696 and 5905 K, exhibiting a good correlation with the CCT of daylight (i.e., 5650 K). 52,53 The details about the CIE coordinate, CRI, and CCT values are described in the Supporting Information.…”

Deciphering Dual Modes of Parkinsonian Biomolecules Derived Fluorescent Nanoparticles: Protein Specificity and White Light Generation

“…Now, all these WL emissive systems are two-component based luminescent systems, which provides an excellent optoelectronic response for the classic drug delivery application and also correlates with many recent important literature findings, which also focus on two or more component based WL emissive systems. 25,26 Furthermore, the molecular mechanism involved behind such WL generation has been supposed to be Forster based resonance energy transfer (FRET) 26,27 or a similar type of energy transfer, operating from the polymeric NPs (energy transfer donor) to the Dox center (energy transfer acceptor), and this has been spectroscopically established in Figure S9 and Table S9. The significantly small size of the synthesized NPs (Figure S2a) may allow the drug molecules to come in close contact with the NP surface after adsorption of protein, and as a consequence, energy transfer becomes favorable.…”