2014
DOI: 10.1530/eje-13-1035
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Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women

Abstract: Objective: There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We aim to study the metabolic and endocrine characteristics of PCOS women with and without a family history (FHx) of type 2 diabetes mellitus (T2DM) and PCOS. Design: Cross-sectional study. Methods: We analysed the association of T2DM FHx and PCOS FHx with metabolic and endocrine parameters in 714 PCOS women. Results: A positive FHx of T2DM and PCOS were prevalent in 36.8 and 21.4% of PCOS women respectivel… Show more

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Cited by 37 publications
(27 citation statements)
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“…44 Moreover, women with monozygotic twin sisters with PCOS have twice the risk of developing the syndrome. 45 In a number of studies, polymorphisms in several genes, including thyroid associated protein, DENN/MADD domain containing 1A and luteinising hormone/choriogonadotropin receptor, were associated with increased risk for PCOS.…”
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confidence: 99%
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“…44 Moreover, women with monozygotic twin sisters with PCOS have twice the risk of developing the syndrome. 45 In a number of studies, polymorphisms in several genes, including thyroid associated protein, DENN/MADD domain containing 1A and luteinising hormone/choriogonadotropin receptor, were associated with increased risk for PCOS.…”
mentioning
confidence: 99%
“…45 In a number of studies, polymorphisms in several genes, including thyroid associated protein, DENN/MADD domain containing 1A and luteinising hormone/choriogonadotropin receptor, were associated with increased risk for PCOS. [44][45][46][47][48] Developmental programming, i.e. changes in gene expression due to the presence of increased steroids, mostly androgens, during fetal development, also appears to increase the risk for IR, prediabetes and T2DM in offspring of patients with PCOS.…”
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confidence: 99%
“…1964-Stein reported the reversal to normal menstrual cycles and conceptions after bilateral ovarian wedge resection in a significant number of PCOS patients. 1980-Burghen and coworkers first reported a close association of hyperandrogenism and hyperinsulinemia in PCOS women 11 .. 12 in 2014 analysed the association of family history of T2DM and PCOS. Results: A positive FHx of T2DM and PCOS were prevalent in 36.8 and 21.4% of PCOS women respectively.…”
Section: Review Of Literaturementioning
confidence: 99%
“…PCOS is characterized by hyperandrogenism, chronic anovulation, and polycystic ovarian morphology (Azziz et al, 2004;Goodarzi and Azziz, 2006). Both environmental and genetic factors contribute to the pathogenesis of PCOS (Azziz et al, 2004;Chen et al, 2011), the latter evidenced by familial aggregation (Goodarzi et al, 2011;Lerchbaum et al, 2014;Vink et al, 2006) and genome-wide association studies (GWAS) (Chen et al, 2011;Cui et al, 2013), which appear to be racially-determined (Wang and Alvero, 2013;Zhao and Qiao, 2013).…”
Section: Introductionmentioning
confidence: 99%