Influence of a thiazole derivative on ethanol and thermally oxidized sunflower oil‐induced oxidative stress

Abstract

The present work describes the protective influence of the dendrodoine analogue (DA) [4-amino-5-benzoyl-2-(4-methoxy phenylamino) thiazole] on thermally oxidized sunflower oil and ethanol-induced oxidative stress. Ethanol was fed to animals at a level of 20% [(7.9 g/kg body weight (bw)] and thermally oxidized sunflower oil at a level of 15% (15 mL/100 g feed). Hepatotoxicity was assessed by measuring the activity of plasma aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), which were elevated in thermally oxidized oil, and ethanol fed rats when compared with normal control rats. Tissue damage was associated with increased lipid peroxidation and disruption in the antioxidant defence mechanism in thermally oxidized oil- and ethanol-fed groups when compared with normal control group. The activity of liver marker enzymes (AST, ALP and GGT) and the level of lipid peroxidation decreased when DA was administered along with ethanol and thermally oxidized oil. The antioxidant status was near normal in DA-administered groups. Thus we propose that DA exerts antioxidant properties by modulating the activity of hepatic marker enzymes, level of lipid peroxidation and antioxidant status.

Transcriptome Analysis Reveals Crosstalk of Responsive Genes to Multiple Abiotic Stresses in Cotton (Gossypium hirsutum L.)

“…A glycolate oxidase (glcD) oxidoreductase gene was activated by NaCl treatment and a G. hirsutum Gibberellin 20-oxidase 1 ( GA20ox1 ) was up-regulated by pH treatment. Interestingly, a gene encoding thiazole biosynthetic enzyme (GeneBank ID: CO076413) was up-regulated over 18 times by all of the five stress conditions, similar result was also reported in other species such as yeast and sunflower [40,41]. Function of more than 40-50% of the identified stress-responsive genes remained unknown.…”

Renoprotective effect ofCapsicum annumagainst ethanol‐induced oxidative stress and renal apoptosis

“…In the present study, a low level of GSH along with elevated levels of GST, GPx, GR, and G6PD were observed in the only ethanol‐treated group. The decreased level of GSH in kidney of rats treated with alcohol is also reported in earlier studies (Kode, Rajagopalan, Penumathsa, & Menon, 2004; Rodrigo et al., 2002). Amplified GST activity may be correlated with the observed decrease in the GSH level of the kidney.…”

Identification of the Therapeutic Effects of Gamma-Irradiated Chamomile Aqueous Extract Against Alcohol Induced Hepato-nephrotoxicity in Rats

“…An over-production of free radicals through the intervention of XOD after alcohol administration could also result from substrates different from acetaldehyde and have greater affinities for XOD (Nordmann et al, 1992). Numerous reportsstated that GSH level was decreased in kidney tissue of alcohol treated rats (Rodrigo et al, 2002 andKode et al, 2004). The reactive oxygen intermediates generated during alcohol metabolism leads to GSH oxidation resulting in the depletion/reduction of GSH (Balasubramaniyan et al, 2003).…”