2019
DOI: 10.1016/j.ajic.2018.12.002
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Influence of a visible-light continuous environmental disinfection system on microbial contamination and surgical site infections in an orthopedic operating room

Abstract: Background: A growing body of research has demonstrated that manual cleaning and disinfection of the operating room (OR) is suboptimal. Residual environmental contamination may pose an infection risk to the surgical wound. This study evaluates the impact of a visible-light continuous environmental disinfection (CED) system on microbial surface contamination and surgical site infections (SSI) in an OR. Methods: Samples from 25 surfaces within 2 contiguous ORs sharing an air supply were obtained after manual cle… Show more

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Cited by 35 publications
(43 citation statements)
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“…The copyright holder for this preprint this version posted March 15, 2021. ; https://doi.org/10.1101/2021.03.14.435337 doi: bioRxiv preprint inactivation potential has been assessed in pathogenic bacteria such as Listeria spp and Clostridium spp 24,25 , and in fungal species such as Saccharomyces spp and Candida spp 26 . It is thought that the underlying mechanism of blue-light mediated inactivation is associated with absorption of light via photosensitizers such as porphyrins which results in the release of reactive oxygen species (ROS) 27,28 .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The copyright holder for this preprint this version posted March 15, 2021. ; https://doi.org/10.1101/2021.03.14.435337 doi: bioRxiv preprint inactivation potential has been assessed in pathogenic bacteria such as Listeria spp and Clostridium spp 24,25 , and in fungal species such as Saccharomyces spp and Candida spp 26 . It is thought that the underlying mechanism of blue-light mediated inactivation is associated with absorption of light via photosensitizers such as porphyrins which results in the release of reactive oxygen species (ROS) 27,28 .…”
Section: Introductionmentioning
confidence: 99%
“…Germicidal properties of violet-blue visible light (380-500 nm), especially within the range of 405 to 450 nm wavelengths have been appreciated as an alternative to UVC irradiation in whole-room disinfection scenarios where it has shown reduction of bacteria 22,23 in occupied rooms and reductions in surgical site infections 24 . Although 405 nm or closely related wavelengths have been shown to be less germicidal than UVC, its inactivation potential has been assessed in pathogenic bacteria such as Listeria spp and Clostridium spp 24,25 , and in fungal species such as Saccharomyces spp and Candida spp 26 . It is thought that the underlying mechanism of blue-light mediated inactivation is associated with absorption of light via photosensitizers such as porphyrins which results in the release of reactive oxygen species (ROS) 27,28 .…”
Section: Introductionmentioning
confidence: 99%
“…Visible blue light exhibits microbicidal effects in the wavelength range of 405–470 nm [ 25 , [84] , [85] , [86] , [87] , [88] ]. High-intensity narrow-spectrum light at 405 nm has been used for continuous decontamination of inpatient and outpatient burn units and patient-occupied intensive care isolation rooms, as well as the treatment of surgical site infections in an orthopedic operating room [ [89] , [90] , [91] ]. Compared to UV-C, in general terms antimicrobial blue light (aBL) requires a much higher radiant exposure (or longer exposure times) to reach similar levels of microbial inactivation if irradiance of the light sources is similar.…”
Section: Antimicrobial Blue Lightmentioning
confidence: 99%
“…Contamination can help mitigate human factors known to limit the impact of environmental surface cleaning alone. [76,77] An effective sampling strategy for OR PathTrac analysis has been delineated. [67] A 5-step strategy with simple interventions to decrease the incidence of HAI has been described in Table 2.…”
Section: The Anesthesia Providermentioning
confidence: 99%