Zirconia is used as a biomaterial due to its mechanical and chemical properties, and acceptaple aesthetic outcomes. Zirconia is used for crown and bridge restorations, implant abutments, implant material, endodontic posts, orthodontic brackets and primary material crown in telescopic attachment in dentistry.In this article, mechanical and physical properties of zirconia in dentistry is reviewed, CAD-CAM systems and a focus on the clinical use and cementation procedures in dental practice with recent research is discussed.