Influence of acoustic stimulation on the circadian and ultradian rhythm of premature infants

Dorn, Franziska; Wirth, Lara; Gorbey, Stefan; Wege, Mirjam; Zemlin, Michael; Maier, Rolf F.

doi:10.3109/07420528.2014.948183

Cited by 30 publications

(58 citation statements)

References 75 publications

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“…The primary focus was not necessarily on CCR development [64]. The results from studies on preterm infants were either in line with ours regarding time for onset of CCR [70,74], or the studies were not designed to cover that time period (one month CA) [68,69,[71][72][73]. De Weerth et al investigated the dynamics of cortisol levels among infants age nine months, with risk factors similar to our group of infants at high psychosocial risk, and concluded that high maternal stress predicts high infant cortisol levels with high total AUC; our findings of high variability in AUC along with CCR curves that do not flatten over time are consistent with these results.…”

Section: Development Of Salivary Cortisol Circadian Rhythmsupporting

confidence: 57%

“…All samples were collected on the same day and not for the purpose of investigating CCR development. Viewing our results in relation to CCR development and comparing them with the diversity of approaches and results from earlier studies entailing a) infants at early age (<three weeks PNA) [69,71,73], b)…”

Section: Development Of Salivary Cortisol Circadian Rhythmmentioning

confidence: 99%

“…Cortisol levels peak in the morning and subsequently drop to a nadir in the evening [59,60] Seven earlier studies have explored the development of CCR in preterm infants [68][69][70][71][72][73][74], three of which investigated cortisol in saliva [69][70][71]. To date, there has been no general consensus regarding when CCR is established.…”

Section: Cortisol Circadian Rhythmmentioning

confidence: 99%

“…Seven earlier studies have investigated development of salivary CCR in full-term infants [61][62][63][64][65][66][67] and an additional seven studies have investigated CCR development in preterm infants [68][69][70][71][72][73][74] (saliva, plasma, or serum), whereas only one study has examined CCR in high psychosocial risk infants at <twelve months of age [100] (saliva).…”

Section: Development Of Salivary Cortisol Circadian Rhythmmentioning

confidence: 99%

“…To improve the situation for neonates in the NICU, stress-reducing interventions have been implemented [146][147][148][149][150] and evaluated [71,120,122]. Salivary cortisol levels early in the life of preterm infants have been studied in response to various painful treatmentrelated hospital interventions such as heel lance [124,[151][152][153][154][155][156][157], eye screening examination [122], and various other painful procedures [151].…”

Section: Interventionsmentioning

confidence: 99%

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Stress : Clinical and Developmental Aspects of Salivary Cortisol in Infants

Ivars¹

2016

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A functional stress-response system is essential for survival at birth, as well as for health and further development. Altered cortisol response and hypothalamic-pituitary-adrenal system function may have both short and long-term effects on health and development throughout life. Cortisol secretion follows a circadian rhythm in adults. Data in the literature concerning basal cortisol levels is scant, with divergent results regarding the timeframe for establishment of cortisol circadian rhythm in children. Nevertheless, cortisol is often studied in stress-related research concerning preterm infants, full-term infants, and infants at high psychosocial risk. This thesis aimed to investigate at what age cortisol circadian rhythm develops in healthy full-term infants, preterm infants, and infants at high psychosocial risk and to identify whether such development is dependent on gestational or postnatal age. A secondary aim was to investigate whether either behavioral regularity or daily life trauma are associated with establishment of cortisol circadian rhythm. The last two interventional studies explored whether a) parental participation in the Hagadal daycare attachment program in one study and b) oral administration of glucose during nasopharyngeal suctioning in the other study influenced development of salivary cortisol circadian rhythm and/or cortisol levels. The effects, if any, of the Hagadal daycare attachment program on caregiver sensitivity to infants were also investigated. The present thesis includes four original studies. Papers I, II, and III describes prospective, longitudinal studies extending over a year, including a survey of the cortisol levels and development of cortisol circadian rhythm in three infant groups. Paper III also included an intervention component addressing the possible effects of the Hagadal daycare attachment program. Paper IV describes a case-control study designed to generate paired baseline-response data concerning the effects of oral glucose administration during nasopharyngeal suctioning as an interventional procedure. Cortisol circadian rhythm in salivary cortisol secretion was similarly established at one month postnatal age in full-term infants and at one month corrected age in preterm infants, reflecting a process dependent on gestational age. This rhythm persisted throughout the first year of life in all infants and consolidated over time in healthy full-term and preterm infants, but not in infants at high psychosocial risk, who displayed higher variability in cortisol levels. The infants in paper IV had not yet reached one month of corrected age and therefore had not yet developed cortisol circadian rhythm at the time of the investigation. No correlation was found between development of cortisol circadian rhythm and either behavioral regularity or reported traumatic life events. This thesis presents data on salivary cortisol levels among three different groups of infants during the first year of life. Cortisol circadian rhythm among infants in study III evolved in respon...

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