Abstract:It was determined that change in DNA content in macronuclei occurs in the T. pyriformis infuso ria under the influence of an activator (caffeine) and inhibitors of Ca 2+ channels (verapamil), NiCl 2 , and CdCl 2 . Caffeine (10 mM) stimulates DNA synthesis. Verapamil (5 µM), CdCl 2 (125 µM), and NiCl 2 (100 µM) decrease DNA content in macronuclei by 30 min after proliferative stimulation. By 4 h of incuba tion, there is, on average, 10% less DNA in macronuclei of Tetrahymena preprocessed with verapamil than in … Show more
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