Influence of acupuncture on maternal serum levels of interleukin-8, prostaglandin f2alpha, and beta-endorphin: a matched pair study

Tempfer, Clemens; Zeisler, Harald; Heinzl, Harald; Hefler, Lukas; Husslein, Peter; Kainz, Ch.

doi:10.1016/s0029-7844(98)00200-2

Cited by 25 publications

(17 citation statements)

References 15 publications

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“…Acupuncture has been used in the treatment of various obstetric and gynecological disorders including female infertility, dysmenorrhea, nausea and vomiting during pregnancy and in antepartum treatment to shorten delivery time [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Influence of acupuncture on Doppler ultrasound in pregnant women

Zeisler

Eppel

Husslein

et al. 2001

Ultrasound in Obstet & Gyne

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Section: Introductionmentioning

confidence: 99%

Influence of acupuncture on Doppler ultrasound in pregnant women

Zeisler

Eppel

Husslein

et al. 2001

Ultrasound in Obstet & Gyne

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“…However, recent studies revealed two different opinions as to the effects of acupuncture on the labor. Studies by Tempfer et al (1998) and Zeisler et al (1998) showed a stimulating effect of acupuncture on labor, whereas other studies by Tsuei et al (1977) and Lyrenas et al (1987) indicated an inhibiting effect of acupuncture on labor. However, all of these studies used only statistical methods for explaining the efficacy of acupuncture and did not explain a specific role of acupuncture in regulating the uterus contractility.…”

Section: Discussionmentioning

confidence: 87%

Immunohistochemical Localization of Cyclooxygenase-2 in Pregnant Rat Uterus by Sp-6 Acupuncture

Kim

Hwang

et al. 2003

Am. J. Chin. Med.

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As pregnancy advances, prostaglandins (PG) increase in the uterus, leading to elevated uterine contractility. Therefore, regulating the concentration of PG in the uterus can be a key factor for controlling the duration of labor. Since the synthesis of PGs in the uterus is catalyzed by cyclooxygenase-2 (COX-2), devising a tool to regulate the expression of COX-2 could provide a method for treating complicated labor. In this study, Sp-6 acupuncture treatment was evaluated for its potential in controlling uterine motility. Immunohistochemical methods showed the COX-2 enzyme was primarily found in the endometrium and myometrium of rat uterus. COX-2 expression in these two locations were intensified by pregnancy, but reduced by acupuncture at the Sp-6 acupoint. Uterine motility monitored during Sp-6 acupuncture was reduced by 28.15% (p < 0.05) and 19.88% (p < 0.05) in pregnant rats and non-pregnant rats, respectively. The significant reduction of uterine motility in pregnant rat suggests a role for Sp-6 acupuncture in regulating the expression of COX-2 during pregnancy. These results suggest that Sp-6 acupuncture could be used as a complementary method for controlling labor in human pregnancy.

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“…A study in rats suggested that manual acupuncture analgesia probably occurred through a contribution from collagen fibers, whereas electroacupuncture analgesia is involved with peripheral nerve receptors [49]. Some studies have suggested that electroacupuncture is more effective than is manual acupuncture in raising the pain threshold and changing the blood flow by causing a greater effect on central endorphins, such as beta-endorphin or dynophins [50-52]. Other studies have reported that manual acupuncture and electroacupuncture have comparable effects [53,54], or that manual acupuncture is superior to electroacupuncture in similar conditions because it more readily elicits deqi sensations, which are conveyed by type III and IV nerve fibers [48].…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture to treat painful diabetic neuropathy: study protocol for a three-armed, randomized, controlled pilot trial

Lee

Kim

Shin

et al. 2013

Trials

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BackgroundThe purpose of this study is to conduct a basic analysis of the effectiveness and safety of electroacupuncture in the treatment of painful diabetic neuropathy (PDN) as compared to placebo and usual care and to evaluate the feasibility of large-scale clinical research.Methods/designThis study is a protocol for a three-armed, randomized, patient-assessor-blinded (to the type of treatment), controlled pilot trial. Forty-five participants with a ≥ six month history of PDN and a mean weekly pain score of ≥ 4 on the 11-point Pain Intensity Numerical Rating Scale (PI-NRS) will be assigned to the electroacupuncture group (n = 15), sham group (n = 15) or usual care group (n = 15). The participants assigned to the electroacupuncture group will receive electroacupuncture (remaining for 30 minutes with a mixed current of 2 Hz/120 Hz and 80% of the bearable intensity) at 12 standard acupuncture points (bilateral ST36, GB39, SP9, SP6, LR3 and GB41) twice per week for eight weeks (a total of 16 sessions) as well as the usual care. The participants in the sham group will receive sham electroacupuncture (no electrical current will be passed to the needle, but the light will be seen, and the sound of the pulse generator will be heard by the participants) at non-acupuncture points as well as the usual care. The participants in the usual care group will not receive electroacupuncture treatment during the study period and will receive only the usual care. The follow-up will be in the 5th, 9th and 17th weeks after random allocation. The PI-NRS score assessed at the ninth week will be the primary outcome measurement used in this study. The Short-Form McGill Pain Questionnaire (SF-MPQ), a sleep disturbance score (11-point Likert scale), the Short-Form 36v2 Health Survey (SF-36), the Beck Depression Inventory (BDI) and the Patient Global Impression of Change (PGIC) will be used as outcome variables to evaluate the effectiveness of the acupuncture. Safety will be assessed at every visit.DiscussionThe result of this trial will provide a basis for the effectiveness and safety of electroacupuncture for PDN.Trial registrationClinical Research information Service. Unique identifier: KCT0000466.

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Influence of acupuncture on maternal serum levels of interleukin-8, prostaglandin f2alpha, and beta-endorphin: a matched pair study

Cited by 25 publications

References 15 publications

Influence of acupuncture on Doppler ultrasound in pregnant women

Influence of acupuncture on Doppler ultrasound in pregnant women

Immunohistochemical Localization of Cyclooxygenase-2 in Pregnant Rat Uterus by Sp-6 Acupuncture

Electroacupuncture to treat painful diabetic neuropathy: study protocol for a three-armed, randomized, controlled pilot trial

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