Influence of Acupuncture Treatment on Cerebral Activity in Functional Dyspepsia Patients and Its Relationship With Efficacy

Zeng, Fang; Qin, Wei; Ma, Tingting; Sun, Jinbo; Tang, Yong; Yuan, Kai; Liu, Ying; Liu, Jixin; Liu, Xuguang; Song, Wenqiang; Lan, Lei; Liu, Mailan; Yu, Shu-Guang; Gao, Xin; Tian, Jie; Liang, Fanrong

doi:10.1038/ajg.2012.53

Cited by 106 publications

(115 citation statements)

References 36 publications

Supporting

Mentioning

108

Contrasting

Order By: Relevance

“…In recent years, a considerable number of studies have been performed to establish the therapeutic roles of acupuncture in treating functional gastrointestinal diseases. [10][11][12] PC6 (Neiguan) and ST36 (Zusanli) are major acupuncture points for improving gastrointestinal motility disorders. 13 Electroacupuncture (EA) is a modified acupuncture technique in which small electric current is applied to the acupoints via the acupuncture needles.…”

Section: Introductionmentioning

confidence: 99%

Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects

Huang

Zhang²,

et al. 2016

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects

Huang

Zhang²,

et al. 2016

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…In our previous studies, we have demonstrated the therapeutic effect of acupuncture in treating FD by a large-sample randomized trial, in which itopride and non-acupoint acupuncture were used as positive and negative controls [15.] Further, we explored the biological effects and cerebral glycometabolic responses elicited by acupuncture by using metabonomic and neuroimaging approaches [16,17.] However, retrospective analyses of the differences in treatment response between FD subgroups are still needed to identify the type and symptoms of FD that are more responsive to acupuncture treatments.…”

Section: Introductionmentioning

confidence: 99%

Which Subtype of Functional Dyspepsia Patients Responses Better to Acupuncture? A Retrospective Analysis of a Randomized Controlled Trial

Ma¹,

Zeng²,

Li³

et al. 2015

Complement Med Res

Self Cite

View full text Add to dashboard Cite

Background: Whether subgroups of functional dyspepsia (FD) should be treated with different approaches is controversially discussed in research. As our previous study has demonstrated the effect of acupuncture in FD treatment, we now further analyze the therapeutic effect of acupuncture in the treatment of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Methods: A retrospective analysis was conducted in 465 eligible PDS patients and 241 EPS patients. 4 acupuncture groups (group A: specific acupoints along the stomach meridian; group B: non-specific acupoints along the stomach meridian; group C: alarm and transport acupoints; group D: specific acupoints along the gallbladder meridian) were compared with a non-acupoint sham acupuncture group and an itopride group. The patients were treated in 5 consecutive sessions per week for 4 weeks and were followed-up for 12 weeks afterwards. Primary outcome of the study was defined as response rate and symptom improvement as measured by the Symptom Index of Dyspepsia, while secondary outcome was designated as improvement in quality of life (QoL) as determined by the Nepean Dyspepsia Index. Results: Symptoms of dyspepsia and QoL were improved from baseline in all groups. In EPS patients, no statistically significant differences could be observed in response rate (p = 0.239) and symptoms improvement (p = 0.344 for epigastric pain; p = 0.465 for epigastric burning). In contrast, PDS patients of the acupuncture group A showed higher response rate (53.2% vs. 19.7%, p<0.001; 53.2% vs. 35.1%, p = 0.025) and score change in postprandial fullness (1.01 vs. 0.27, p<0.001; 1.01 vs. 0.57, p<0.001), early satiation (0.81 vs. 0.21, p<0.001; 0.81 vs. 0.39, p=0.001), and QoL (14.5 vs. 4.33, p<0.001; 14.5 vs. 8.5, p<0.001) compared to the sham acupuncture and itopride group. Conclusions: FD patients with PDS responded better to the acupuncture therapies, especially at the specific acupoints along the stomach meridian. The positive therapeutic effect of acupuncture on PDS was correlated with the improvement in postprandial fullness. Trial Registration: ClinicalTrial.gov NCT00599677.

show abstract

“…Li/Zeng/Yang/Chen/Zhang/Sun/Qin/Yang/ Liang more, our previous PET-CT study demonstrated that acupuncture treatment could not only modulate the homeostatic afferent network, including the insula, ACC and hypothalamus, but it could also significantly improve the symptoms and quality of life of FD patients [15]. It is thus clear that the efficacy of acupuncture treatments for FD might result partly from modulating the functions of the homeostatic afferent processing network.…”

Section: Discussionmentioning

confidence: 99%

Different Cerebral Responses to Puncturing at ST36 among Patients with Functional Dyspepsia and Healthy Subjects

Li¹,

Zeng²,

Yang³

et al. 2014

Complement Med Res

Self Cite

View full text Add to dashboard Cite

Background: Little research has been done on the connection between functional status and acupuncture efficacy; however, functional status is a key factor in the study of acupuncture efficacy. Therefore, we have tried to compare functional dyspepsia (FD) patients with healthy subjects (HS) to determine the different cerebral responses elicited by acupuncture stimulation at Zusanli (ST36). Patients and Methods: In this study, 24 FD patients and 24 HS were given acupuncture stimulation at ST36 while being monitored by an fMRI scan. Results: Compared with HS, FD patients showed an fMRI signal decrease in the right anterior cingulate cortex, right medial prefrontal cortex, right orbitofrontal cortex, left superior occipital gyrus, and right cuneus; but on the other hand, there was an fMRI signal increase in the right insula, right postcentral gyrus, and right supramarginal gyrus. Conclusion: Acupuncture stimulation at ST36 evoked pronounced changes, especially in the homeostatic afferent processing network of FD patients, compared to HS. We hypothesize that the cerebral responses elicited by acupuncture stimulation in certain diseases, such as FD are correlated to specific regions. The action of stimulating acupoints might be dynamic; the functional status is therefore an essential impact factor for cerebral responses to acupuncture stimulation.

show abstract

Influence of Acupuncture Treatment on Cerebral Activity in Functional Dyspepsia Patients and Its Relationship With Efficacy

Cited by 106 publications

References 36 publications

Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects

Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects

Which Subtype of Functional Dyspepsia Patients Responses Better to Acupuncture? A Retrospective Analysis of a Randomized Controlled Trial

Different Cerebral Responses to Puncturing at ST36 among Patients with Functional Dyspepsia and Healthy Subjects

Contact Info

Product

Resources

About