Influence of Acute Alcohol Intake and Alcohol Withdrawal on Circulating Levels of Il-6, Il-8, Il-10 and Il-12.

González‐Quintela, Arturo; Domínguez-Santalla, Maria-Jesus; Pérez, Luis‐Fernando; Vidal, Carmen; Lojo, S.; Barrio, E.

doi:10.1006/cyto.2000.0715

Cited by 75 publications

(53 citation statements)

References 11 publications

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“…Therefore, it has been suggested that chronic ethanol ingestion per se may play a role in increasing IgE (Miguez Burbano et al, 1995). Likewise, it has been shown that ethanol-related IgE increase is independent of associated habits such as smoking, both in alcoholics and in a defined healthy population (González-Quintela et al, 2000). From this data it may be hypothesized that IgE increases in alcoholics might be due to alcohol and its metabolites per se, which would mean that alcohol could act as an additional antigen or allergen (Domínguez-Santalla et al, 2001).…”

Section: Ethanol and Humoral Immunitymentioning

confidence: 94%

“…On the other hand, IL-8 increases have been shown in healthy subjects after being submitted to alcohol consumption. It has been suggested that the increased synthesis especially of IL-6 and Th2 cytokines, such as IL-10 and IL-13, in alcoholics could be involved in promoting IgE synthesis (González-Quintela et al, 2000). However, further studies are necessary to establish the influence of alcohol consumption on interleukin production and its implication on IgE production.…”

Section: The Role Played By Cytokinesmentioning

confidence: 99%

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Influence of alcohol consumption on immunological status: a review

et al. 2002

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The aim of this review is to present and discuss the effect of different levels of alcohol consumption on the immune system. Not only the amount consumed but also the type of alcoholic beverage have to be taken into account in order to determine the consequences on activity, number, distribution, balance, interaction and response of immunocompetent cells. The association between alcohol exposure and the risk of developing an alcohol-related disease is multifactorial. In fact, age, gender, smoking habits, dietary intake and exercise are involved among other factors. The evaluation of the host cellular and humoral immune responses has shown that alcohol may induce some benefits when consumption is moderate. Moreover, those alcoholic beverages that contain antioxidants, such as red wine, could be protectors against immune cell damage. According to the literature consulted, the daily consumption of 10 -12 g and 20 -24 g of alcohol for women and men, respectively, is considered to be a moderate intake; the type of beverage has been established not to be important when defining moderation. Particular attention is often focused on the U-or J-shaped curve which also suggests that light to moderate drinking produces a protective effect. Such an inverse relationship indicates a reduction of risk for both light and moderate consumers and a higher risk not only for hard drinkers, but also for non-consumers.

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Section: Ethanol and Humoral Immunitymentioning

confidence: 94%

Section: The Role Played By Cytokinesmentioning

confidence: 99%

Influence of alcohol consumption on immunological status: a review

et al. 2002

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“…a reduction in CD3 + , CD4 + and CD8 + cell numbers) (21) and B lymphocytes, natural killer cells and monocytes/macrophages, as well as altering cytokine production (22)(23)(24) and concentration (i.e. an increase of pro-inflammatory cytokines such as TNFa and IL-6 (25)(26)(27) ). Moreover, high alcohol doses and abusive alcohol consumption lead to deterioration in both non-specific and cell-mediated immunity, independent of the alcoholic beverage type (5,(28)(29)(30) .…”

Section: Alcohol Abusementioning

confidence: 99%

“…For example, red wines contain many bioactive flavonoids and antioxidants (43) and beer contains phenolic compounds derived from hops and malts (44) . Several studies have stressed the importance of different active components contained in fermented alcoholic beverages such as wine or beer on immunity and inflammation, which may exert protective effects (5,25,35,39) . Although alcohol per se reliably increases HDLcholesterol levels, other effects on oxidation, endothelial function and the immune response seem to be due to the substances prevalent in polyphenol-rich alcoholic beverages other than ethanol itself (5,31,35,45) .…”

Section: Polyphenol-rich Alcoholic Beveragesmentioning

confidence: 99%

“…On the other hand, while a decrease in IL-10, IL-2 and interferon-g levels have frequently been found in alcoholic pathology (25,26) , moderate wine and beer consumption in human subjects has been shown to increase the production of anti-inflammatory IL-10 cytokine, also reducing some of the inflammatory mechanisms involved in atheromatous plaque formation (4,37) . Reviewing the literature, the relationship between the alcoholic beverage type and inflammation remains unresolved and requires further research.…”

Section: Alcohol and Inflammationmentioning

confidence: 99%

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Drinking pattern and socio-cultural aspects on immune response: an overview

2010

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Social acceptance of drinking involves social and cultural roles and has important implications for public health. Since extensive evidence indicates that alcohol possesses immunomodulatory properties, scientists have recently debated the influence of alcohol consumption on the immune response, particularly in countries where drinking in a social setting is a part of cultural identity. Experimental and clinical data support the conclusion that alcohol is a potent immunomodulator. While high alcohol consumption suppresses a wide range of immune responses, leading to an increased incidence of a number of infectious diseases, moderate alcohol consumption may have a beneficial impact on the immune system, compared to alcohol abuse or abstinence, most likely due to the multiple components of polyphenol-rich alcoholic contributing to the protective effect seen for moderate alcohol consumption on CVD and the immune system. Despite this, the scientific literature appears to be concerned about the diseases associated with excessive drinking in some societies and cultures. Thus, the present review recognizes the importance to consider social and cultural aspects of drinking when examining the whole dimension of alcohol consumption (amount, beverage type, frequency and variability), in order to estimate global risk of consequences on host defence to better understand alcohol-related harm or benefit.

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Affinity Peptidomics Approach to Protein Detection, Quantification, and Protein Affinity Assays: Application to Forensics and Biometrics

Bailes

Soloviev

2007

Peptidomics

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Influence of Acute Alcohol Intake and Alcohol Withdrawal on Circulating Levels of Il-6, Il-8, Il-10 and Il-12.

Cited by 75 publications

References 11 publications

Influence of alcohol consumption on immunological status: a review

Influence of alcohol consumption on immunological status: a review

Drinking pattern and socio-cultural aspects on immune response: an overview

Affinity Peptidomics Approach to Protein Detection, Quantification, and Protein Affinity Assays: Application to Forensics and Biometrics

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