Influence of acute and unpredictable chronic stress on spatio-temporal dynamics of exploratory activity in zebrafish with emphasis on homebase-related behaviors

Borba, João V.; Biasuz, Eduarda; Sabadin, Giovana R.; Savicki, Ana C.; Canzian, Julia; Luchiari, Ana Carolina; Adedara, Isaac A.; Rosemberg, Denis Broock

doi:10.1016/j.bbr.2022.114034

Cited by 14 publications

(2 citation statements)

References 53 publications

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“…Thus, unlike terrestrial vertebrates and humans, zebrafish continuously absorb these substances, which in turn may also play a role in modulating their stress responsivity. Nevertheless, although this factor may contribute to some discrepancy in physiological and behavioral responses to stress in fish vs. humans, there are also multiple well-described and simple experimental protocols to access acute stress responses in zebrafish [ 34 , 37 ]. Thus, despite these environmental differences, the overall neuroendocrine similarity between zebrafish and humans, together with well-described behavioral stress protocols, collectively make zebrafish a reliable model to study stress-related brain disorders.…”

Section: Current State Of Studying Zebrafish Model Of Psychiatric Dis...mentioning

confidence: 99%

Current State of Modeling Human Psychiatric Disorders Using Zebrafish

Costa

Колесникова

Galstyan

et al. 2023

IJMS

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Psychiatric disorders are highly prevalent brain pathologies that represent an urgent, unmet biomedical problem. Since reliable clinical diagnoses are essential for the treatment of psychiatric disorders, their animal models with robust, relevant behavioral and physiological endpoints become necessary. Zebrafish (Danio rerio) display well-defined, complex behaviors in major neurobehavioral domains which are evolutionarily conserved and strikingly parallel to those seen in rodents and humans. Although zebrafish are increasingly often used to model psychiatric disorders, there are also multiple challenges with such models as well. The field may therefore benefit from a balanced, disease-oriented discussion that considers the clinical prevalence, the pathological complexity, and societal importance of the disorders in question, and the extent of its detalization in zebrafish central nervous system (CNS) studies. Here, we critically discuss the use of zebrafish for modeling human psychiatric disorders in general, and highlight the topics for further in-depth consideration, in order to foster and (re)focus translational biological neuroscience research utilizing zebrafish. Recent developments in molecular biology research utilizing this model species have also been summarized here, collectively calling for a wider use of zebrafish in translational CNS disease modeling.

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Section: Current State Of Studying Zebrafish Model Of Psychiatric Dis...mentioning

confidence: 99%

Current State of Modeling Human Psychiatric Disorders Using Zebrafish

Costa

Колесникова

Galstyan

et al. 2023

IJMS

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“…Many vertebrate and invertebrate species favour moving along walls as opposed to open areas [9][10][11][12]. The preference for wall following is driven by various factors, and avoiding predation, alleviating anxiety and using the wall as a means of exploration or an exit are the most common explanations [13][14][15][16]. Movement along walls differs from movement in open areas in various aspects, such as increasing or decreasing speed upon reaching the wall (cf.…”

Section: Introductionmentioning

confidence: 99%

Flour beetles prefer corners over walls and are slowed down with increasing habitat complexity

Scharf,

Radai,

Goldshtein

et al. 2024

R. Soc. Open Sci.

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Movement affects all key behaviours in which animals engage, including dispersal and habitat use. The red flour beetle, known as a cosmopolitan pest of stored products, was the subject of our study. We examined whether the beetles preferred corners, walls or open areas, and how turns or obstacles in corridors delayed the beetles' arrival at a target cell. Beetles spent significantly more time in corners than expected by chance, while they spent considerably less time in open areas than expected. However, no significant difference was observed between areas with two or three surrounding walls. This could be attributed to the beetles' stronger attraction to corners than crevices or the insufficient proximity of the third wall to the other two. Movement through the corridor was delayed by turns or obstacles, expressed in arrival probabilities, arrival times, time in the corridor or movement speed. Obstacles on the corridor's perimeter had a stronger effect on the beetle movement than those in the corridor's centre owing to the beetles' tendency to follow walls. The research is important also for applied purposes, such as better understanding beetle movement, how to delay their arrival to new patches, and where to place traps.

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