Influence of Additional Active Ingredients on the Effectiveness of Non‐Alcoholic Chlorhexidine Mouthwashes: A Randomized Controlled Trial

Bascones, A; Morante, S; Mateos, Leopoldo; Mata, Montserrat; Poblet, J.

doi:10.1902/jop.2005.76.9.1469

Cited by 29 publications

(42 citation statements)

References 20 publications

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“…[12] Plaque reduction has been the hallmark of preventive dentistry since the advent of antibiotics and the realization that bacteria are possible causative agents of the major dental diseases, caries, and periodontal disease. [3]…”

Section: Introductionmentioning

confidence: 99%

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Effect of Two Herbal Mouthwashes on Gingival Health of School Children

Sharma

Hebbal

Ankola

et al. 2014

Journal of Traditional and Complementary Medicine

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This study aimed at determining the effect of indigenously prepared neem and mango chewing stick mouthwashes on plaque and gingival indices. A sample of 105 children aged 12-15 years was randomized into three groups, namely neem, mango, and chlorhexidine mouthwash groups. All the children were examined at baseline and gingival and plaque indices were recorded. Baseline scores for plaque and gingivitis were fair and moderate, respectively, in all the three groups and there existed no statistically significant difference among them. Ten millilitres each of herbal and chlorhexidine mouthwashes (0.2%) were administered according to the group allocation twice daily for 21 days. Indices were reassessed at 21 days (immediately after intervention) and at 1 month, 2 months, and 3 months after discontinuing the mouthwashes. Statistically significant reduction (P < 0.001) in plaque index was found in all the three mouthwash groups at 21 days and at 1 month from discontinuing the mouthwash. Chlorhexidine additionally showed statistically significant reduction in plaque index at 2 months from discontinuing the mouthwash. Statistically significant reduction (P < 0.001) in gingival index was found in all the three mouthwash groups at 21 days (immediately after discontinuing the mouthwash) and at 1 and 2 months from discontinuing the mouthwash. To conclude, all the three mouthwashes were effective antiplaque and antigingivitis agents. Chlorhexidine and neem possess equivalent efficacy in reducing plaque, while chlorhexidine has superior antigingivitis properties.

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Section: Introductionmentioning

confidence: 99%

“…However, despite the potential for adequate mechanical plaque control, clinical experience and population-based studies demonstrate that such methods are not being employed sufficiently by large numbers of the population. [24]…”

Section: Introductionmentioning

confidence: 99%

Effect of Two Herbal Mouthwashes on Gingival Health of School Children

Sharma

Hebbal

Ankola

et al. 2014

Journal of Traditional and Complementary Medicine

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“…3 In our case, E cloacae could have played a role in the pathogenesis of black tongue. 1 Pigmented lesions of the tongue are reported in heroin addicts who inhale the heroin smoke.…”

Section: Commentmentioning

confidence: 50%

“…

Black Tongue and Enterobacter cloacae

B lack discoloration of the tongue should be distinguished from black "hairy" tongue, also known as lingua villosa nigra, characterized by hypertrophy or hyperkeratosis of the filiform papillae. 3 In our case, E cloacae could have played a role in the pathogenesis of black tongue. 1 We describe a 92-year-old woman presenting with a black tongue and positive culture findings for Enterobacter cloacae, and we discuss the duality of chlorhexidine and E cloacae in the pathogenesis of black tongue.

Report of a Case.

A 92-year-old woman presented with a black tongue associated with a concomitant dysphagia evolving over 1 year (Figure).

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confidence: 50%

Black Tongue and Enterobacter cloacae

Sayed¹

2007

Arch Dermatol

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“…CHX is a cationic biguanide with broad-spectrum antimicrobial action, whose effectiveness in decreasing the formation of dental biofilm (plaque) and gingivitis has been demonstrated in clinical studies [43, 44]. An important characteristic of chlorhexidine is its substantivity or persistence of action, which consists of the ability of this product to bind to oral tissues and remain active for long periods after application.…”

Section: Discussionmentioning

confidence: 99%

The effect of mouthwashes containing biguanides on the progression of erosion in dentin

et al. 2014

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BackgroundDental erosion is caused by frequent exposure to acids without the involvement of microorganism. This study analyzed the effect of biguanides (polyhexamethylene biguanide – PHMB and chlorhexidine – CHX) on dentin erosion due to their possible influence on the enzymatic degradation of the demineralized organic matrix.MethodSixty bovine dentin specimens were prepared. On both sides of their surface, nail varnish was applied to maintain the reference surfaces for the determination of dentin loss. Samples were cyclically de- and remineralized for 6 days. Demineralization was performed with a 0.87 M citric acid solution (6×5 min daily). Thereafter, samples were treated with distilled water (negative control), 0.12% CHX (positive control), 0.07% PHMB, Sanifill Perio Premium™ (0.07% PHMB plus 0.05% NaF), or F solution (0.05% NaF) for 1 min and then subjected to enzymatic challenge for 10 min using a bacterial collagenase (Clostridium hystoliticum, 100 μg/ml). Dentin loss was assessed using profilometry (μm) daily. Data were analyzed using 2-way repeated measures-ANOVA and Bonferroni’s test (p < 0.05).ResultsDentin loss progressed significantly for all groups during the 6 days. After the 3rd day, Sanifill Premium™, CHX, and PHMB significantly reduced dentin erosion compared to control. On the 6th day, the lowest mean (±SD) dentin loss was observed for Sanifill Perio Premium™ (94.4 ± 3.9 μm). PHMB and CHX led to intermediate dentin loss (129.9 ± 41.2 and 135.3 ± 33.5 μm, respectively) that was significantly lower than those found for negative control (168.2 ± 6.2 μm). F (157.4 ± 6.1 μm) did not significantly differ from negative control.ConclusionsSanifill Perio Premium™ mouthwash has a good potential to reduce dentin loss, which might be associated with the presence of PHMB.

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Influence of Additional Active Ingredients on the Effectiveness of Non‐Alcoholic Chlorhexidine Mouthwashes: A Randomized Controlled Trial

Abstract: In non-alcoholic 0.12% chlorhexidine mouthwashes, the addition of other active ingredients does not produce beneficial effects, but may even reduce the antiplaque effectiveness or increase tongue staining.

Cited by 29 publications

References 20 publications

Effect of Two Herbal Mouthwashes on Gingival Health of School Children

Effect of Two Herbal Mouthwashes on Gingival Health of School Children

Black Tongue and Enterobacter cloacae

The effect of mouthwashes containing biguanides on the progression of erosion in dentin

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