Influence of adjuvant therapy with green tea extract in the treatment of experimental periodontitis

Almeida, Juliano Milanezi de; Marques, Bianca Mayara; Novaes, Vivian Cristina Noronha; Oliveira, Fred Lucas Pinto de; Matheus, Henrique Rinaldi; Fiorin, Luiz Guilherme; Ervolino, Edílson

doi:10.1016/j.archoralbio.2019.03.028

Cited by 16 publications

(9 citation statements)

References 45 publications

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“…Periodontitis is a chronic infectious disease with plaque as the starting factor, and the main principle of the animal periodontitis model is to promote plaque accumulation regardless of how the model is constructed. , Researchers at home and abroad can shorten the modeling time through the combination of various factors, − but the occurrence and development of periodontitis is affected by many factors. To avoid the influence of these factors on the modeling results, an animal model of periodontitis in Wistar rats was constructed by ligation and a high-sugar diet to finally obtain good and stable mold-making effects, , which was combined with simple ligation to successfully construct the periodontitis animal model in week 1, and the associated genes for inflammatory factors and alveolar bone absorption expression of simple ligation increased. , …”

Section: Discussionmentioning

confidence: 99%

“…To avoid the influence of these factors on the modeling results, an animal model of periodontitis in Wistar rats was constructed by ligation and a high-sugar diet to finally obtain good and stable mold-making effects, 36,37 which was combined with simple ligation to successfully construct the periodontitis animal model in week 1, and the associated genes for inflammatory factors and alveolar bone absorption expression of simple ligation increased. 38,39 After the modeling was successful, rats were administered periodically in groups, and then materials were obtained, the periodontal bag was measured, and the inflammatory factors in gingival crevicular fluid were detected, and Micro-CT and tissue histopathological staining were performed. The results showed that phase transfer lysozymes loaded with minocycline hydrochloride showed good anti-inflammatory effects in animal experiments.…”

Section: Discussionmentioning

confidence: 99%

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A Study on the Use of Phase Transition Lysozyme-Loaded Minocycline Hydrochloride in the Local Treatment of Chronic Periodontitis

Wang

Deng

Zhang

et al. 2022

ACS Appl. Bio Mater.

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Periodontitis is the most important oral disease causing human tooth loss. Although supragingival and subgingival scaling is the main strategy of periodontitis clinical treatments, drug treatment has an indispensable auxiliary role to some degree. Periodontitis medical treatment is divided into systemically administered treatments and local periodontally administered treatments. Compared with systemic administration, local administration can increase local drug concentrations, reduce dosages, and prolong action times while also improving patient compliance and avoiding possible adverse effects due to systemic administration responses. However, some studies show that minocycline ointment, a clinical local drug commonly used in periodontal pockets, has an unstable release rate; 80% of the drug is usually released within 2–3 days after pocket placement. This release is not conducive to controlling periodontal infection and may hinder the periodontal tissue repair and regeneration. Therefore, choosing a suitable carrier for minocycline hydrochloride is necessary to control its local release in periodontal tissue. Phase transition lysozyme (PTL) has been widely used in many studies and the development of macromolecular carrier material, and we selected PTL as the carrier for minocycline hydrochloride drugs because of its good biocompatibility, good drug-carrying capacity, and stable release. Due to its release characteristics and simple preparation, PTL is a promising carrier material.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Study on the Use of Phase Transition Lysozyme-Loaded Minocycline Hydrochloride in the Local Treatment of Chronic Periodontitis

Wang

Deng

Zhang

et al. 2022

ACS Appl. Bio Mater.

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“…It has already been observed that the local irrigation of GTE at sites of experimental induction of periodontal disease with the technique of ligature in rats was an adjuvant in the reduction in inflammation, osteoclast activity and alveolar bone loss by histological analysis. 41 A randomized clinical study by Taleghani et al evaluated the effect of green tea consumption after brushing in patients with depth of probing ≥5 mm, showing that the consumption of green tea accompanied by basic periodontal treatment decreased the depth of probing without decreasing the biofilm index. 23 Systematic reviews, such as that of Gartenman et al, analysed the articles that used the topical application of GTE as an adjunct to conventional mechanical therapy, concluding that local application of GTE along with conventional therapy significantly reduced the progression of alveolar bone loss.…”

Section: Discussionmentioning

confidence: 99%

Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease

Sánchez

Pitol

Sousa

et al. 2020

Int J Experimental Path

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Periodontal disease and osteoporosis are characterized by bone resorption, and researchers have shown an association between these two diseases through increasing loss of systemic bone mass and triggering alveolar bone loss. Green tea is a common and easily accessible beverage, and evidences show that flavonoid epigallocatechin gallate (EGCG) could decrease bone loss in pathologies such as osteoporosis and periodontal disease. In order to verify its possible effects and apply them in the treatment and prevention of these diseases, this investigation aimed to evaluate the influence of green tea extract (GTE) on bone metabolism of ovariectomized rats after experimental periodontal disease (EPD) by histological, morphological and microtomographic parameters. Wistar female rats were divided into Sham, Sham + EPD, Sham + EPD + GTE, OVX, OVX + EPD and OVX + EPD + GTE groups. Immediately after surgery, gavage administration of 50 mg/kg of green tea extract (GTE) was performed for 60 days, with subsequent induction of periodontal disease by ligature 15 days before euthanasia. Mandible and femur samples were collected for histological, morphometric and microtomographic analysis. The results were analysed by means of statistical software with significance set at 5%. Histological and morphometric analysis showed a significant decrease in alveolar and femoral trabecular bone loss in groups that received GTE. Microtomographic results showed that trabecular thickness and bone surface density values in alveolar bone interradicular septum of the OVX + EPD + GTE groups were similar to the Sham group. The results obtained suggest that green tea extract may improve bone metabolism in osteoporotic rats with periodontal disease.

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“…The green tea application lowered as well the RANKL expression [102]. Camelia sinensis extract can reduce alveolar bone resorption by reducing cytokines and TRAP-positive multinucleated osteoclasts inhibiting periodontal inflammation [103]. Adjunctive topical extract therapy with a green tea gel reduces inflammation after 4 weeks of daily use [104].…”

Section: Tea Leaves (Camellia Sinensis)mentioning

confidence: 99%

Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review

Gościniak

Paczkowska-Walendowska

Skotnicka

et al. 2021

Pharmaceutics

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Periodontal diseases are one of the most significant challenges in dental health. It is estimated that only a few percent of the worldwide population have entirely healthy teeth, and according to WHO, oral diseases may affect up to 3.5 billion people worldwide. One of the most serious oral diseases is periodontitis, an inflammatory disease affecting periodontal tissues, caused by pathogenic bacteria and environmental factors such as the ageing population, abuse of tobacco products, and lack of adequate oral hygiene due low public awareness. Plant materials are widely and successfully used in the management of many conditions, including periodontitis. Plant materials for periodontitis exhibit antibacterial, anti-inflammatory, antioxidant activities and affect the periodontium structure. Numerous studies demonstrate the advantages of phytotherapy for periodontitis relief and indicate the usefulness of Baikal skullcap root, Pomegranate fruit peel and root cortex, Tea leaves, Chamomile flowers, Magnolia bark, Blackberry leaves and fruits, Cranberry fruits and Lippia sidoides essential oil. This review aims to analyze the use and applicability of selected plant materials in periodontitis management since it is of paramount importance to evaluate the evidence of the traditionally used plant materials in light of continuously growing interest in phytotherapy and its adjuvant role in the treatment of periodontitis.

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Influence of adjuvant therapy with green tea extract in the treatment of experimental periodontitis

Cited by 16 publications

References 45 publications

A Study on the Use of Phase Transition Lysozyme-Loaded Minocycline Hydrochloride in the Local Treatment of Chronic Periodontitis

A Study on the Use of Phase Transition Lysozyme-Loaded Minocycline Hydrochloride in the Local Treatment of Chronic Periodontitis

Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease

Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review

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