Influence of age and cognitive performance on resting-state functional connectivity of dopaminergic and noradrenergic centers

Zareba, Michal Rafal; Furman, Wiktoria; Binder, Marek

doi:10.1016/j.brainres.2022.148082

Cited by 3 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One sample t-tests revealed that the functional connectivity patterns of LC, VTA and DR were in line with those reported in the literature, thus confirming their correct delineation (Beliveau et al, 2015;Murty et al, 2014;Zareba et al, 2022). The results are presented in Supplementary Figures 2-4.…”

Section: Trait-anxiety Fully Mediates the Association Between Maladap...supporting

confidence: 85%

Noradrenergic and Dopaminergic Neural Correlates of Trait Anxiety: Unveiling the Impact of Maladaptive Emotion Regulation

Zareba,

Ariño-Braña,

Picó-Pérez

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Maladaptive emotion regulation plays a crucial role in the development and maintenance of elevated anxiety levels, both in patients and in individuals with subclinical symptomatology. While pharmacological treatments for anxiety target the emotion dysregulation through dopaminergic, noradrenergic and serotonergic systems, little is known about the underlying mechanisms. Therefore, the current study depicts the association of these neuromodulatory systems' resting-state functioning with trait-anxiety, investigating the role of maladaptive emotion regulation. Amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and whole-brain resting-state functional connectivity (rs-FC) were obtained from the ventral tegmental area (VTA), locus coeruleus (LC) and dorsal raphe, and correlated with trait-anxiety and self-reported maladaptive emotion regulation (N = 60). Trait-anxiety was positively associated with LC's fALFF and negatively with VTA's whole-brain rs-FC with the left inferior parietal lobule (L-IPL) and the left superior frontal gyrus (L-SFG). Maladaptive emotion regulation was negatively associated with VTA's rs-FC with these regions, with trait-anxiety fully mediating this association. VTA connectivity with the frontal region, but not parietal, positively predicted its amplitude of neural oscillations, an effect that was paralleled by stronger frontal dopaminergic innervation. In conclusion, noradrenergic and dopaminergic systems appear to contribute differently to subclinical anxiety. While noradrenaline likely acts through a more general mechanism, the dopaminergic dysconnectivity with the frontoparietal control network may act as one of the mechanisms of maladaptive emotion regulation, informing the models on the disorder development.

show abstract

Section: Trait-anxiety Fully Mediates the Association Between Maladap...supporting

confidence: 85%