Influence of age and gender on alveolar bone healing post tooth extraction in 129 Sv mice: a microtomographic, histological, and biochemical characterization

Biguetti, Cláudia Cristina; Chandrashekar, Bhuvana Lakkasetter; Simionato, Gustavo Baroni; Momesso, Nataira Regina; Duarte, Marco Antônio Húngaro; Rodrigues, Danieli C.; Matsumoto, Mariza Akemi

doi:10.1007/s00784-023-05087-y

Cited by 6 publications

(4 citation statements)

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“…Contrary to previous studies indicating increased muscle loss in female patients [ 26 ], the findings in this study highlight the benefits of BSM augmentation for female patients following traumatic long bone fractures. Although previous preclinical studies suggested increased resorption activity in female patients and a higher rate of osteoclasts and TRAP in aged female mice [ 2 ], the clinical findings contradict this assumption. Geriatric female patients demonstrated an improved bone healing process.…”

Section: Discussionmentioning

confidence: 80%

“…The findings of this study regarding reduced pseudarthrosis in female patients using bone substitute material align with the assumption that it supports the bone healing process following bone defect augmentation [ 31 ]. Notably, female geriatric patients exhibited an improved healing process with fewer nonunions, contrary to delayed bone healing processes observed in female geriatric mice [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Male subjects experienced greater regional bone mineral content and density loss, while females exhibited a trend toward increased muscle loss [ 1 ]. Additionally, aged female mice displayed increased resorption activity, larger osteoclasts, and elevated TRAP following alveolar extraction [ 2 ]. Middle-aged female osteotomized rats exhibited impaired bone healing [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the aging population and increased incidence of fractures in the elderly present a future challenge [ 17 ]. From the assumption of increased bone resorption activity following alveolar bone extraction in elderly mice, the bone healing process in female geriatric patients could be delayed [ 2 ]. Furthermore, elderly female patients exhibited decreased CFU-APs in the bone marrow essential for bone formation [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Retrospective Analysis of Bone Substitute Material for Traumatic Long Bone Fractures: Sex-Specific Outcomes

Pawelke,

Vinayahalingam,

Heiss

et al. 2023

IJMS

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Male patients often experience increased bone and muscle loss after traumatic fractures. This study aims to compare the treatment outcomes of male and female patients with large bone defects. A total of 345 trauma patients underwent surgery, with participants divided into two groups: one receiving bone substitute material (BSM) for augmented defects (n = 192) and the other without augmentation (empty defects = ED, n = 153). Outcome parameters were assessed among female (n = 184) and male (n = 161) patients. Descriptive statistics revealed no significant differences between male and female patients. Approximately one-half of the fractures resulted from high-energy trauma (n = 187). The BSM group experienced fewer complications (p = 0.004), including pseudarthrosis (BSM: n = 1, ED: n = 7; p = 0.02). Among female patients over 65, the incidence of pseudarthrosis was lower in the BSM group (p = 0.01), while younger females showed no significant differences (p = 0.4). Radiologically, we observed premature bone healing with subsequent harmonization. Post hoc power analysis demonstrated a power of 0.99. Augmenting bone defects, especially with bone substitute material, may reduce complications, including pseudarthrosis, in female patients. Additionally, this material accelerates bone healing. Further prospective studies are necessary for confirmation.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%