Influence of Age and Nutritional Status on Glycated Albumin Values in Hemodialysis Patients

Okada, Tomonari; Nakao, Toshiyuki; Matsumoto, Hiroshi; Yamanaka, Taro; Nagaoka, Yume; Tamekuni, Tokiyo

doi:10.2169/internalmedicine.48.2301

Cited by 14 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sev- eral previous studies demonstrated the factors affecting GA values, including body mass index (BMI) (9, 10), chronic liver disease (11), or thyroid function (12). Our previous study showed that age, BMI, and serum cholinesterase level were significantly associated with GA values in non-diabetic hemodialysis patients (13). The present study first showed the influence of proteinuria on GA values.…”

Section: Discussionsupporting

confidence: 55%

“…Glycated albumin (GA) is an alternative glycemic marker which has been shown to be more accurate for the assessment of glycemic control than HbA1c in diabetic dialysis patients (6)(7)(8). However, GA values are influenced by several physiological factors or diseases associated with albumin turnover (9)(10)(11)(12)(13). Therefore, it is possible that proteinuric renal diseases may influence GA values independent of glycemic state.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Proteinuria on Glycated Albumin Values in Diabetic Patients with Chronic Kidney Disease

et al. 2011

Self Cite

View full text Add to dashboard Cite

Background Glycated albumin (GA), which is an alternative glycemic marker, is influenced by factors associated with albumin turnover, and it is not clear whether proteinuria influences GA values in diabetic patients with chronic kidney disease (CKD). Methods We enrolled 94 diabetic patients with CKD stages 3 to 5. GA, glycated hemoglobin, and urinary protein excretion (UP) levels were consecutively obtained in each patient. The correlations between GA and UP and those between changes in GA and UP were examined. Results There was a significant correlation between GA and UP in all cases (r=-0.46, p<0.0001), however no significant correlation was found in cases with UP of 0-3.49 g/day (r=0.01). GA values in cases with UP "3.5 g/day were significantly lower than those in cases with UP <3.5 g/day [UP "3.5 g/day and serum albumin (Alb) !3 g/dL; 12.0 ± 1.3%, UP "3.5 g/day and Alb >3 g/dL; 17.8 ± 4.3%, 0" UP <3.5 g/day; 21.2 ± 4.2%], while no significant difference in HbA1c or glucose levels was found. In cases with a minimum of UP "0.5 g/day, no significant correlation was found between the difference in GA and the difference in UP at the point of maximum UP and minimum UP (r=0.04). Conclusion Nephrotic-range proteinuria decreases GA values independent of the glycemic state, while nonnephrotic range proteinuria has no significant influence on GA values in diabetic CKD patients.

show abstract

Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Influence of Proteinuria on Glycated Albumin Values in Diabetic Patients with Chronic Kidney Disease

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the precise mechanism for the lower GA in obesity is unclear. 52 , 53 , 56 – 58 GA may be artificially low in individuals with increased BMI, body fat mass, and visceral adiposity. 53 The mechanism for alterations in GA levels in these conditions is not well understood.…”

Section: Diagnostic Biomarkers and Their Clinical Utilitymentioning

confidence: 99%

Novel biomarkers for prediabetes, diabetes, and associated complications

Dorcely

Katz

Jagannathan

et al. 2017

DMSO

170

104

View full text Add to dashboard Cite

The number of individuals with prediabetes is expected to grow substantially and estimated to globally affect 482 million people by 2040. Therefore, effective methods for diagnosing prediabetes will be required to reduce the risk of progressing to diabetes and its complications. The current biomarkers, glycated hemoglobin (HbA1c), fructosamine, and glycated albumin have limitations including moderate sensitivity and specificity and are inaccurate in certain clinical conditions. Therefore, identification of additional biomarkers is being explored recognizing that any single biomarker will also likely have inherent limitations. Therefore, combining several biomarkers may more precisely identify those at high risk for developing prediabetes and subsequent progression to diabetes. This review describes recently identified biomarkers and their potential utility for addressing the burgeoning epidemic of dysglycemic disorders.

show abstract

“…(6) Glycated albumin is an alternative glycaemic marker, which is more accurate for the assessment of glycaemic control than HbA1c (M. Inaba et al, 2007). (6) However, glycated albumin values are influenced by several physiological factors or diseases associated with albumin turnover (T. Okada et al, 2009). (7) Glycated albumin (GA) (8) more accurately reflects changes in plasma glucose during the short term and postprandial plasma glucose.…”

Section: Introductionmentioning

confidence: 99%

“…(6) However, glycated albumin values are influenced by several physiological factors or diseases associated with albumin turnover (T. Okada et al, 2009). (7) Glycated albumin (GA) (8) more accurately reflects changes in plasma glucose during the short term and postprandial plasma glucose. It reflects mean glucose over the period of 2 -3 weeks (N. Furusyo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Study of Glycaemic Biomarkers in the Patients of Thyroid Disorders

Chowdhry¹,

Kaushik²

2017

jemds

View full text Add to dashboard Cite

BACKGROUNDThyroid disorders are commonest disorders worldwide. Various glycated proteins can be used as glycaemic biomarkers to determine the degree of glycaemia in thyroid patients. They are useful glycaemic biomarkers to monitor the short-term glycaemic changes in the patients with thyroid disorders and have a role in conjugation with glycated haemoglobin. Serum fructosamine and glycated albumin correlate well with serum glucose.So, the present study was conducted to evaluate the changes and compare the levels of various glycaemic biomarkers like serum fructosamine, glycated albumin, glycated haemoglobin in overt hypothyroid, subclinical hypothyroid, hyperthyroid patients in comparison to controls and the levels of total protein and serum albumin was estimated in thyroid disorder patients. MATERIALS AND METHODSThe present descriptive comparative study has been conducted on 300 subjects of either sex of various age groups. Study included diagnosed thyroid disorder patients (200) RESULTSThe mean serum fructosamine were higher in overt hypothyroid and subclinical hypothyroid patients in comparison to healthy control, vice-a-versa was found in hyperthyroid patients (p < 0.001) (HS). Mean glycated albumin levels were higher in overt hypothyroid patients (p < 0.005) and subclinical hypothyroid patients in comparison to healthy control, vice-a-versa was found in hyperthyroid patients. Total protein levels were higher in overt hypothyroid and subclinical hypothyroid patients. Serum albumin levels were higher in overt hypothyroid patients in comparison to hyperthyroid and healthy control, which was statistically significant. CONCLUSIONThe present study concluded that serum fructosamine and serum glycated albumin are better short-term glycaemic markers than glycated haemoglobin and fasting blood glucose level in thyroid disorder patients. KEYWORDSSerum Fructosamine, Glycated Albumin, Glycated Haemoglobin. HOW TO CITE THIS ARTICLE:Chowdhry V, Kaushik GG. Study of glycaemic biomarkers in the patients of thyroid disorders.

show abstract

Influence of Age and Nutritional Status on Glycated Albumin Values in Hemodialysis Patients

Abstract: Objective Several studies have shown glycated albumin (GA) BMI, and GA values (r=0.515, p= 0.0004, p=0.010, p=0.036). Stepwise multivariate regression analysis showed that age and ChE values were significant independent variables associated with GA values (β=0.479, R 2 =0.382

Cited by 14 publications

References 23 publications

Influence of Proteinuria on Glycated Albumin Values in Diabetic Patients with Chronic Kidney Disease

Influence of Proteinuria on Glycated Albumin Values in Diabetic Patients with Chronic Kidney Disease

Novel biomarkers for prediabetes, diabetes, and associated complications

Study of Glycaemic Biomarkers in the Patients of Thyroid Disorders

Contact Info

Product

Resources

About