Influence of age and subtype in outcome of operable liposarcoma

Greto, Daniela; Saieva, Calogero; Loi, Mauro; Terziani, Francesca; Visani, Luca; Garlatti, Pietro; Russo, Monica Lo; Muntoni, Cristina; Becherini, Carlotta; Topulli, J.; Campanacci, Domenico Andrea; Beltrami, Giovanni; Scoccianti, Guido; Muratori, Francesco; Bonomo, Pierluigi; Desideri, Isacco; Livi, Lorenzo

doi:10.1007/s11547-018-0958-4

Cited by 12 publications

(13 citation statements)

References 36 publications

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“…Liposarcoma histology also influences survival prognosis. Histological features such as differences in patterns of reoccurrence, metastatic risk, and grade, all influence survival [10,11,30]. Our data showed well-differentiated histology as the most common liposarcoma sub-type (33.04%) with the highest 5-year survival of 95.5% (Tables 2 and 4).…”

Section: Discussionmentioning

confidence: 66%

Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016

Bock

Hoffmann

Jiang

et al. 2020

IJERPH

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Rare cancers, affecting 1 in 5 cancer patients, disproportionally contribute to cancer mortality. This research focuses on liposarcoma, an understudied rare cancer with unknown risk factors and limited treatment options. Liposarcoma incident cases were identified from the U.S. Surveillance, Epidemiology, and End Result (SEER) program and the combined SEER-National Program of Cancer Registries (CNPCR) between 2001-2016. Incidence rates (age-adjusted and age-specific), 5-year survival, and the time trends were determined using SEER*stat software. Three-dimensional visualization of age-time curves was conducted for males and females. SEER liposarcoma cases represented~30% (n = 11,162) of the nationwide pool (N = 37,499). Both sources of data showed males accounting for~60% of the cases; 82%-86% cases were identified among whites. Age-adjusted incidence was greater among males vs. females and whites vs. blacks, whereas survival did not differ by sex and race. The dedifferentiated (57.2%), pleomorphic (64.1%), and retroperitoneal (63.9%) tumors had the worse survival. Nationwide, liposarcoma rates increased by 19%, with the annual percent increase (APC) of 1.43% (95% confidence interval (CI): 1.12-1.74). The APC was greater for males vs. females (1.67% vs. 0.89%) and retroperitoneal vs. extremity tumors (1.94% vs. 0.58%). Thus, incidence increased faster in the high-risk subgroup (males), and for retroperitoneal tumors, the low-survival subtype. The SEER generally over-estimated the rates and time trends compared to nationwide data but under-estimated time trends for retroperitoneal tumors. The time trends suggest an interaction between genetic and non-genetic modifiable risk factors may play a role in the etiology of this malignancy. Differences between SEER and CNCPR findings emphasize the need for nationwide cancer surveillance.have a considerable impact on the overall cancer outcomes. Limited treatment options, high costs of existing treatments, and frequent misdiagnosis of rare cancers burden patients, physicians, and health systems [4]. The lack of epidemiological knowledge about the risk factors associated with many rare cancers precludes the development of viable prevention, making it one of the most dramatic unresolved public health problems [1,3,5]. In comparison, well-studied cancers such as colorectal cancer, which constitutes a smaller portion of the overall cancer cases (13%), has had significant progress in cancer control and prevention [5,6]. The existing gaps in research and treatment are reflected in rare cancer survival rates. The 5-year survival for rare cancers is worse compared to common cancers: 49% vs. 63% in Europe [5]; and the U.S., 55% vs. 75% among males and 60% vs. 74% among females [4]. In light of these facts, population-based surveillance of rare cancers and their descriptive epidemiology provide the foundation for advancing etiological and clinical research with the ultimate goal of reducing the public health burden of rare cancers.This research focuses on the under-studied rare cancer...

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Section: Discussionmentioning

confidence: 66%

Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016

Bock

Hoffmann

Jiang

et al. 2020

IJERPH

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“…This study found that age at diagnosis was a significant independent predictor of survival. Greto et al, [ 15 ] confirmed that age older than 65 years was an adverse independent predictor of recurrence and OS among patients with operable LS. Maybe elderly patients obtain specific genomic alterations and present with larger tumors at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Maybe elderly patients obtain specific genomic alterations and present with larger tumors at diagnosis. [ 15 – 17 ] Langman et al, [ 13 ] however, reported that age at diagnosis of advanced disease was not associated with OS based on univariate analysis. We noted that sex was not a prognostic predictor, which was congruent with many previous studies.…”

Section: Discussionmentioning

confidence: 99%

Survival analysis and treatment strategies for limb liposarcoma patients with metastasis at presentation

et al. 2021

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Limited data exist on patients with limb liposarcoma (LLS) with metastasis at presentation Moreover, the potential prognostic factors of this patient population are poorly documented because of its rarity. Therefore, we conducted this study to evaluate the clinicopathologic characteristics and prognostic factors for patients with metastatic LLS. All patients with LLS with metastasis at presentation from 1975 to 2016 were identified by using the Surveillance, Epidemiology, and End Results (SEER) database. The following clinical data were derived from this clinical database: age, sex, histologic grade, subtype, size of tumor, surgery, radiotherapy, chemotherapy, vital status, cause of death, and survival duration. The Kaplan-Meier method was performed to calculate median survival time and draw survivorship curves. Cox-proportional hazards regression model was used to reveal the statistical independence between various variables. The present study collected 184 cases from SEER database for survival analysis. Mean age was 57.8 years with 63.6% (n = 117) men. The 3-year overall survival (OS) and cancer-specific survival (CSS) rates of this population were 27.8% and 30.1%, respectively. Univariate analysis revealed that age, tumor grade, and surgery were significantly correlated with survival. Sex and tumor size did not reach significant predictor status of survival. Multivariate analysis revealed that age at diagnosis <60, low tumor grade, and local surgery were significantly correlated with improved OS and CSS. Patients with LLS with metastasis at diagnosis experienced quite poor prognosis. Currently, surgery for the primary tumor significantly prolonged the survival of those patients, whereas chemotherapy and radiotherapy need to be further confirmed.

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“…In that nomogram, vascular sarcoma was associated with the poorest prognosis, while myxoid liposarcoma was associated with the best prognosis. Moreover, MPNST reportedly has a poor prognosis (8) and myxoid liposarcoma has a good prognosis (11,12), with the outcomes also potentially being affected by the occurrence of distant metastasis. In this context, chemotherapy and radiotherapy are thought to have an elevated influence on the prognosis of patients with distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Histological Subtype in Soft Tissue Sarcoma With Distant Metastasis

Tsuchie¹,

Emori²,

Miyakoshi³

et al. 2020

In Vivo

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Background/Aim: Few studies have examined the prognostic significance of histological subtypes in patients with soft tissue sarcoma (STS) and distant metastasis, and we evaluated the relationship between the histological subtypes and clinical outcomes. Patients and Methods: This retrospective study evaluated the histological subtypes of 105 patients with STS and distant metastasis. The STS histological subtypes were compared based on the clinical information. Results: The Kaplan-Meier curves for overall survival revealed that myxoid liposarcoma had a significantly better prognosis compared to Malignant Peripheral Nerve Sheath Tumor (MPNST) (p=0.0221). In the multivariate logistic regression analyses, the independent predictors of a poor prognosis were: i) large size, ii) advanced stage, and iii) non-surgical treatment for metastasis (p<0.05). The presence or absence of lung metastasis was not significantly associated with prognosis (p=0.4452). Conclusion: Myxoid liposarcoma had a better prognosis compared to MPNST in STS patients with distant metastasis. The surgical removal of distant metastatic lesions may improve the patient's prognosis. Soft tissue sarcoma (STS) is relatively rare, and mainly occurs in middle-aged or older individuals. Despite its low incidence, STS has various histological subtypes, such as liposarcoma and synovial sarcoma, which results in relatively small populations of patients with different histological types. Radical resection with adequate margins is important for treating STS, regardless of the histological subtype, in order to prevent local recurrence. However, recent developments in surgical treatment, radiotherapy, and chemotherapy have improved patient outcomes (1), and various studies have identified factors associated with prognosis among STS patients (2-10). There is consensus that distant metastasis, which mainly involves the lungs, has a strong influence on prognosis. However, the small sample sizes for each subtype typically prevent studies from identifying a clear relationship between subtype and prognosis, despite the fact that several reports have examined the prognostic significance of the STS histological subtypes (2-8, 11, 12). Moreover, only few studies have examined this topic among patients with STS and distant metastases. Therefore, the present study aimed to examine the association of clinical outcomes with the histological subtypes and distant metastasis sites in patients with STS and distant metastasis. 1975 This article is freely accessible online.

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Influence of age and subtype in outcome of operable liposarcoma

Cited by 12 publications

References 36 publications

Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016

Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016

Survival analysis and treatment strategies for limb liposarcoma patients with metastasis at presentation

Prognostic Significance of Histological Subtype in Soft Tissue Sarcoma With Distant Metastasis

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