Influence of age and vascular disease on cerebral hemodynamics and metabolism

Fazekas, Joseph F.; Kleh, Jack; Finnerty, Frank A.

doi:10.1016/0002-9343(55)90228-x

Cited by 46 publications

(14 citation statements)

References 15 publications

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“…cerebral blood flow and cerebral metabolic rate decrease progressively with advancing age, while cerebro-vascular resistance increases. Several simi lar studies have confused these results by including patients with vascular dis ease [9,22] or specifically with cerebro-atherosclerosis [3][4][5], Further contami nation of the influence of age is provided by the investigation of mentally subnormal patients [10] and those confined in a psychiatric institution [16], Rheoencephalography (REG) is an adaptation of electrical impedance plethysmography applied to the cerebral circulation. The output of the trans ducer is in the form of an analogue of the pulse wave detected by electrodes applied to the scalp but dependent upon physiodynamics of electrical forces within the skull.…”

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confidence: 99%

Influence of Human Ageing on Aspects of the Cerebral Circulation

Doust¹

1972

Gerontology

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Cerebral impedance plethysmography (REG) is a non-traumatic, reproducible method of continuously monitoring aspects y of the cerebral circulation. Its use in more than 200 healthy subjects aged 6–70 years was investigated, measurements being applied to three characteristics of the standardized averaged REG wave form. It was found that inflow angle and percent rise time changed progressively and significantly as chronological age advanced but amplitude was not so affected. Menstrual status, sex and hemispheric sidedness were not significant variables. The role of REG as a monitor of the ageing process in man is discussed.

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confidence: 99%

Influence of Human Ageing on Aspects of the Cerebral Circulation

Doust¹

1972

Gerontology

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“…The relationship between cerebral blood flow and age has been discussed by many researchers 8–13 . According to these studies, the age‐related decline of cerebral blood flow seems to be a progressive phenomenon which begins in youth and continues through adulthood and old age.…”

Section: Discussionmentioning

confidence: 99%

“…Regional cerebral blood flow (rCBF) in man has been studied extensively in a variety of pathologic and physiologic conditions over the last two decades. Many studies showed that progressive rCBF reduction occurred with advancing age 8–13 . However there have been few reports about rCBF reduction in relation to brain atrophy during aging.…”

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confidence: 99%

Correlations between Regional Cerebral Blood Flow and Age‐related Brain Atrophy: A Quantitative Study with Computed Tomography and the Xenon‐133 Inhalation Method

Yamaguchi¹,

Hatazawa²,

Kubota³

et al. 1983

J American Geriatrics Society

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One hundred and two subjects (40 men and 62 women) neither having a history of neurologic deficits nor showing organic lesions on computed tomographic examination of the brain were studied. Ages of the subjects ranged from 26 to 81 years. Regional cerebral blood flow was measured by the xenon-133 inhalation method, and the volume percentage of brain with respect to the cranial cavity (craniocerebral index) was calculated by means of computer programs. Regional cerebral blood flow was computed as the fast component of two-compartmental analysis and as the initial slope index value. The percentage of each subject's craniocerebral index in relation to the standard for subjects with non-atrophied brains (brain volume index) was calculated as the indicator of brain atrophy. Both the mean brain fast component values and the mean brain initial slope index values correlated closely with the brain volume index in the elderly (r = 0.60, r = 0.62; P less than 0.0001 in each correlation coefficient). Low cerebral blood flow values coincided with loss of brain substance in the final stage of age-related brain atrophy, but not in the intermediate stage.

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“…Although this differenee was statistically significant, (p <.02) both values were "normal"' or slightly inereased for people in this age group. [9][10][11][12] In 10 persons with mild to nmoderate cardiac decomnpensation, relief of the congestive state was associated with a significant (p<.01) de-eline in cerebral blood flow. Mean arterial blood pressure also deereased significantly-(p<.02); cerebral vascular resistacee, on the other hand, remained unchanged.…”

Section: Measurements Of Cerebral Blood Flowmentioning

confidence: 96%