Influence of age and vitamin C status on serum cholesterol

Kothari, L. K.; Pramod, John; Sharma, Praveen; Chaturvedi, Shashi

doi:10.1093/ije/17.4.929-a

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Average subject age varied between 48 and 82 years; and it is known that vitamin C concentration in serum decreases with aging, whereas a concomitant increase in total serum concentration occurs. 67 Differences in age and dietary characteristics may result in unevenly matched baseline plasma vitamin C concentrations. In the 9 groups where baseline plasma vitamin C concentrations were observed, the range varied between 28 and 75 μmol.…”

Section: Discussionmentioning

confidence: 99%

Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials

McRae

2008

Journal of Chiropractic Medicine

121

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials

McRae

2008

Journal of Chiropractic Medicine

121

View full text Add to dashboard Cite

show abstract

“…It is likely that cholesterol lowering effect of vitamin C is affected by several factors like initial cholesterol levels, age and sex of the subjects, dose and mode of the administration. The influence of age may be important because SAA levels have been found to be lower in elderly as compared to adolescents [101,102] and therefore elderly subjects could be more responsive to the administration of vitamin C. In UK, a study showed that the risk of stroke in those with highest intake of vitamin C was only half that of subjects with the lowest intake. No evidence is suggestive of lower rate of CHD in those with high vitamin C intake [103].…”

Section: Vitamin C and Atherosclerosismentioning

confidence: 99%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

Self Cite

View full text Add to dashboard Cite

The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management.

show abstract

“…It is a rich source of vitamin C (478.56 mg/100 ml) and the levels are much higher than those in oranges, tangerines, or lemons [12]. Studies have also reported that deficiencies of vitamin C may results into hyperlipidaemia and also affects the serum cholesterol levels associated with liver dysfunctions [16][17][18]. Besides, it also contains flavonoids including quercetin, kaempferol 3 O-a-L (600 methyl) rhamnopyranoside and kaempferol 3 O-a-L (600 ethyl) rhamnopyranoside [19,20] that are associate with its antioxidant potential.…”

Section: Introductionmentioning

confidence: 99%

Arsenic-Induced Hepatic Toxicity and Its Attenuation by Fruit Extract of Emblica officinalis (Amla) in Mice

et al. 2013

Self Cite

View full text Add to dashboard Cite

Arsenic a metalloid and environmental contaminated has been found to be associated with public health problems in the affected areas. It is naturally occurred in groundwater and its accumulation in plant and animals leads to toxicity in several tissues most notably hepatic organ. Arsenic exposures (3 mg/kg body weight/ day for 30 days) in mice exhibited increased arsenic and Zn levels in hepatocytes associated with enhanced oxidative stress in hepatocytes while there were no significantly changes were observed in Cu level. An increase in the lipid peroxidation and decrease in the levels of reduced glutathione and activity of superoxide dismutase, catalase, and glutathione peroxidase were observed in arsenic treated mice as compared to controls. Arsenic exposure in mice also caused a significant change in serum biomarkers in the SGOT, SGPT and creatinine as compared to the controls. There were no significant changes in the serum levels of total protein in these mice. Co-administration of arsenic and fruit extract of amla (500 mg/kg body weight/day for 30 days) caused a significant reduction of arsenic transference associated with significantly decreases hepatic arsenic levels and balanced the antioxidant enzyme and levels of serum hepatic enzymes like SGOT and SGPT. The results of the present study clearly demonstrate the antioxidant property of amla that could be responsible for its protective efficacy in arsenic induced hepatic toxicity.

show abstract

Influence of age and vitamin C status on serum cholesterol

Cited by 6 publications

References 0 publications

Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials

Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials

Vitamin C in Disease Prevention and Cure: An Overview

Arsenic-Induced Hepatic Toxicity and Its Attenuation by Fruit Extract of Emblica officinalis (Amla) in Mice

Contact Info

Product

Resources

About