Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT study

Abstract

Elderly onset CD may be related to favorable outcomes in Korea. Thus, the heterogeneity of this disease should be considered when developing a tailored strategy for the treatment of CD.

Temporal trend of disease recognition, treatment paradigm, and clinical outcomes of Crohn disease in Thailand from 2000 through 2017

“…The majority of cohorts from Asia also showed L2 to be the least likely location of involvement; however, more colonic involvement was found in Western cohorts. [ 3 , 6 , 13 , 16 , 20 , 27 , 34 , 40 , 41 , 44 , 48 ] Similar to other studies, most of the patients in our study had inflammatory phenotype at diagnosis.…”

“…[ 3 , 6 , 9 , 12 – 14 , 16 , 20 , 22 , 25 , 27 , 28 , 30 , 34 , 40 , 41 , 44 , 48 – 50 ] There was no gender preference in our cohort, which is similar to many cohorts from Western countries, [ 3 , 20 , 31 , 35 , 41 ] but most cohorts from Asia reported male predominance at 60% to 70%. [ 6 , 9 , 13 , 15 , 22 , 27 , 28 , 30 , 34 , 44 , 48 , 49 ] The locations of disease at diagnosis in our cohort were L3 (40%), L1 (35%), and L2 (25%). The majority of cohorts from Asia also showed L2 to be the least likely location of involvement; however, more colonic involvement was found in Western cohorts.…”

“…These proportions of medications used are comparable to those reported from many cohorts from Asia with reported rates of mesalamine, glucocorticoids, thiopurines, and biologics use of 70% to 98.9%, 35% to 100%, 29% to 92.6%, and 0% to 33%, respectively. [ 9 , 12 , 13 , 15 , 27 , 28 , 33 , 48 ] Comparable rates of immunomodulator and biologic use were also reported from pre-2010 Western cohorts with rates of 25% to 64% for immunomodulators, and 0% to 32% for biologics. [ 14 , 20 , 31 , 35 , 40 ] Interestingly, there was a significant trend toward early initiation of immunomodulators and biologics in the later study period.…”

Doença inflamatória intestinal no idoso

“…A proporção de pacientes diagnosticados com DII aos 60 anos ou mais, demonstrada em uma série de estudos (Tabela 1), varia entre 3 e 21% para DC e de 7 a 29% para a RCU. A maioria (65%) foi diagnosticada durante a 6ª década de vida, 25% na 7ª e 10% na 8ª décadas [4][5][6][7][8][9][10][11][12] . No idoso, a incidência de RCU é maior do que a de DC.…”

“…Proporção de pacientes diagnosticados após os 60 anos entre todos os pacientes com doença inflamatória intestinal1,[4][5][6][7][8][9][10][11][12] …”