Influence of Age, Growth, Castration and Testosterone Treatment on the Noradrenaline Levels of the Ductus Deferens and the Auxiliary Male Reproductive Glands of the Rat

Sjöstrand, Nils O.; Swedin, Göran

doi:10.1111/j.1748-1716.1976.tb10317.x

Cited by 37 publications

(12 citation statements)

References 27 publications

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“…Thus, androgens are necessary for the development and function of the male genital tract (Sjöstrand and Swedin 1976;Pereira et al 1991) and androgens may also modulate the noradrenergic response in vas deferens isolated from rats (Pereira et al 1998). In the present study, treatment of intact rats with nandrolone decanoate for 2 weeks did not change either the body mass or vas deferens wet weight.…”

Section: Discussionmentioning

confidence: 96%

Effects of swimming and nandrolone decanoate treatment on vas deferens response to norepinephrine

2009

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Aims: To investigate the response to norepinephrine of vas deferens isolated from intact and castrated rats submitted to swimming and/or treated with nandrolone decanoate. Main methods: Intact and castrated male rats were submitted to swimming for 15 days, 1 session per day, 5 days/week and were either treated or not with 7.5 mg/kg of nandrolone decanoate on days 1, 5, 9, and 13 after the beginning of training. Plasma androgen concentration was measured by radioimmunoassay. Vas deferens was isolated and set up for analysis of its contractile capacity in response to norepinephrine. Key findings: In intact rats, nandrolone, training, and training plus nandrolone did not change body mass or vas deferens weight. In castrated rats, the vas deferens wet weight was decreased in both untrained and trained groups. In castrated rats, nandrolone prevented vas deferens atrophy. In intact animals, nandrolone decreased (P < 0.05) the androgen level in untrained group, while in castrated rats this treatment partially restored the androgen level. An increased sensitivity (P < 0.05) to norepinephrine was observed in vas deferens isolated from intact trained rats, treated or not with nandrolone decanoate, while nandrolone did not alter norepinephrine response in organs from untrained animals. In untrained castrated rats, nandrolone fully restored the sensitivity to norepinephrine in untrained rats, while in trained castrated rats the anabolic steroid only partially restored this response. Significance: The present results indicate that training can increase norepinephrine response of vas deferens in intact rats, while nandrolone decanoate can partially restore the responsiveness to norepinephrine in castrated rats.

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Section: Discussionmentioning

confidence: 96%

Effects of swimming and nandrolone decanoate treatment on vas deferens response to norepinephrine

2009

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“…Another potential T-NE interaction may occur through enhanced sympathetic outflow, which can increase blood pressure [14]. Sjöstrand and Swedin showed that androgens have no substantial direct effect on adrenergic innervation per se , but that they do affect the transmitter levels of the male organs indirectly through changes in the number, size and relative proportion of the target cells of the adrenergic nerves, that is, the smooth muscle cells [41]. Using males with defective ARs (testicular feminized males), our research group found that CAST decreased dopamine in several brain areas associated with blood pressure control [42].…”

Section: Discussionmentioning

confidence: 99%

Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation

et al. 2012

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BackgroundTestosterone (T) and the sympathetic nervous system each contribute to the pathology of hypertension. Altered blood vessel reactivity is also associated with the pathology of high blood pressure. The purpose of this study was to examine the effects of T manipulation in the regulation of resistance-sized blood vessel reactivity.MethodsAdult spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) male rats at 8 weeks of age were used. The rats were divided into groups consisting of gonadally intact controls (CONT), castrate with sham implant (CAST) and castrate with T implant (CAST + T) (n = 6 to 12 per group). Following a short-term period of T treatment (approximately 4 weeks), plasma norepinephrine (NE) and plasma T were assessed by performing high-performance liquid chromatography and RIA, respectively. Resistance-sized mesenteric artery reactivity was assessed on a pressurized arteriograph for myogenic reactivity (MYO), phenylephrine (PE) responsiveness and passive structural mechanics.ResultsSHR and WKY males exhibited similar physiological trends in T manipulation, with castration significantly lowering plasma T and NE and T replacement significantly increasing plasma T and NE. T manipulation in general resulted in significant alterations in MYO of second-order mesenteric arteries, with T replacement decreasing MYO in SHR (P < 0.05) compared to CONT, T replacement increasing MYO, and CAST decreasing MYO in WKY rats (P < 0.001) compared to CONT rats. Additionally, PE-induced constriction was significantly altered in both strains following T treatment, with the effective concentration of PE to constrict the vessel to 50% of the total diameter significantly increased in the CAST + T SHR compared to CONT (P < 0.05). Comparisons of passive structural mechanics between SHR and WKY treatment groups indicated in SHR a significantly increased wall-to-lumen ratio and decreased circumferential wall stress compared to WKY treatment groups.ConclusionsThese data suggest that T and NE are involved in a complex interaction with both myogenic reactivity and structural alterations of resistance-sized blood vessels and that these factors likely contribute to the development and maintenance of hypertension.

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“…NA was determined with the trihydroxyindole method according to Chang (1964). Extraction, absorption and elution were performed as described by Sjostrand and Swedin (1976). Except on the canine rp all estimations were done on pieces weighing about 0.5 g cut from the middle part of the muscle.…”

Section: Measurements Of Acetylcholine (Ach) and Noradrenaline ( N A )mentioning

confidence: 99%

“…This report presents evidence indicating that the function of cholinergic nerves in the dog rp as well as in the rp of some other species may in fact be suppression of the excitatory adrenergic neurotransmission. Preliminary accounts of the present study have been presented earlier Sjostrand 1976, Sjostrand and.…”

mentioning

confidence: 97%

Suppression of the Excitatory Adrenergic Neurotransmission; a Possible Role of Cholinergic Nerves in the Retractor Penis Muscle

Klinge

Sjöstrand

1977

Acta Physiologica Scandinavica

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The excitatory adrenergic response to transmural nerve stimulation of the isolated retractor penis (rp) of dog, cat, horse, boar, elk, bull, ram and goat, as well as the evoked release of 3H from dog rp preloaded with 3H-noradrenaline were studied. In untreated preparations a low concentration of scopolamine could markedly increase the excitatory adrenergic response. On the contrary, physostigmine per se suppressed this response and so did acetylcholine. Scopolamine or atropine totally prevented these suppressions. They also immediately restored the suppressed responses in spite of continuous presence of physostigmine and/or acetylcholine. In the rat rp there was no suppression of the response by physostigmine. Physostigmine decreased the evoked release of 3H and this effect was counteracted by scopolamine. The rp of dog, gelding, boar, hog, bull and ram contained considerable amounts of noradrenaline and also of acetylcholine. It is suggested that one action of cholinergic nerves in the rp is muscarine suppression of the excitatory adrenergic neurotransmission.

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Influence of Age, Growth, Castration and Testosterone Treatment on the Noradrenaline Levels of the Ductus Deferens and the Auxiliary Male Reproductive Glands of the Rat

Cited by 37 publications

References 27 publications

Effects of swimming and nandrolone decanoate treatment on vas deferens response to norepinephrine

Effects of swimming and nandrolone decanoate treatment on vas deferens response to norepinephrine

Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation

Suppression of the Excitatory Adrenergic Neurotransmission; a Possible Role of Cholinergic Nerves in the Retractor Penis Muscle

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