Influence of age on atrial activation as measured by the P-wave signal-averaged electrocardiogram

Babaev, Anvar; Vloka, Margot E.; Sadurski, Rafal; Steinberg, Jonathan S.

doi:10.1016/s0002-9149(00)01056-0

Cited by 41 publications

(33 citation statements)

References 11 publications

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“…The increase in left atrial size made atrial arrhythmias more likely [26][27][28]. An age dependent prolongation of FPD was also found in other studies [17,28].…”

Section: Age Dependent Relationshipsupporting

confidence: 73%

“…The increase in left atrial size made atrial arrhythmias more likely [26][27][28]. An age dependent prolongation of FPD was also found in other studies [17,28]. The reason for the positive correlation of atrial arrhythmias, FPD and atrial size seems to be the increased incidence of atrial fibrosis in the older population [29], which causes a reduction of conduction velocity in the atrium [30].…”

Section: Age Dependent Relationshipsupporting

confidence: 54%

See 1 more Smart Citation

P wave signal averaged ECG and chemoreflexsensitivity in paroxysmal atrial fibrillation

Budeus

Hennersdorf

Wieneke

et al. 2005

International Journal of Cardiology

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“…The increase in left atrial size made atrial arrhythmias more likely [26][27][28]. An age dependent prolongation of FPD was also found in other studies [17,28].…”

Section: Age Dependent Relationshipsupporting

confidence: 73%

Section: Age Dependent Relationshipsupporting

confidence: 54%

P wave signal averaged ECG and chemoreflexsensitivity in paroxysmal atrial fibrillation

Budeus

Hennersdorf

Wieneke

et al. 2005

International Journal of Cardiology

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“…Sakabe et al (13) reported a positive correlation between percentage atrial fragmentation index as a marker of conduction and advancing age in 73 patients with no history of AF or structural heart disease. P-wave duration on signal-averaged ECG has been shown to prolong with advancing age (15).…”

Section: Tionship To Atrial Structural Changesmentioning

confidence: 99%

Electrophysiologic and electroanatomic changes in the human atrium associated with age

Kistler

Sanders

Fynn

et al. 2004

Journal of the American College of Cardiology

388

270

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“…12 The reason for that is likely to be the age-related atrial fibrosis 13 that results in a slowing of atrial conduction observed during sinus rhythm, either as an increased prevalence of fractionated atrial electrograms 14 , or abnormal P-wave morphology 15 or duration. 16,17 Conduction slowing, therefore, can lead to less and larger reentry circuits expressed in a slower AFR on surface ECG. The age-related decrease in AFR observed in the MUSIC population is, therefore, well in line with these observations.…”

Section: Age-related Afr Slowingmentioning

confidence: 99%

Low Atrial Fibrillatory Rate Is Associated With Poor Outcome in Patients With Mild to Moderate Heart Failure

Platonov

Cygankiewicz

Stridh

et al. 2012

Circ: Arrhythmia and Electrophysiology

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Background-Atrial fibrillatory rate (AFR) is a measure of atrial remodeling caused by atrial fibrillation (AF), and its acceleration negatively affects outcome of interventions for persistent AF. However, the prognostic value of AFR in patients with congestive heart failure (CHF) has not been studied. We sought to evaluate whether AFR can predict outcome in patients with mild to moderate (New York Health Association II-III) CHF. Methods and Results-High-resolution 20-minute long Holter ECGs obtained from 169 CHF patients with AF at enrollment were analyzed. AFR was estimated using spatiotemporal QRST cancellation and time-frequency analysis. The patients were followed for a median of 44 months, with primary end point defined as total mortality and secondary end points as sudden death and heart failure death. Atrial signal quality was sufficient for AFR estimation in 142 patients (mean age 69Ϯ11 years, 101 male). Of those, 48 patients died during follow-up, including 18 because of CHF progression. Mean AFR was 390Ϯ60 fpm and decreased with age (rϭϪ0.3, PϽ0.001). Patients with AFR Յ371 fpm (lower tertile) had 44% 3-year mortality as compared with 26% with higher AFR. Lower AFR was an independent predictor of all cause mortality (HRϭ1.99, 95% CIϭ1.09 -3.63, Pϭ0.025) and CHF death (HRϭ3.74, 95% CIϭ1.38 -10.14, Pϭ0.010) after adjustment for significant clinical covariates in multivariable Cox analysis. Conclusions-In CHF patients with AF, reduced AFR assessed using noninvasive approach is associated with increased risk of death because of heart failure progression, and may be considered a predictor of outcome. (Circ Arrhythm Electrophysiol. 2012;5:77-83.)

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Influence of age on atrial activation as measured by the P-wave signal-averaged electrocardiogram

Cited by 41 publications

References 11 publications

P wave signal averaged ECG and chemoreflexsensitivity in paroxysmal atrial fibrillation

P wave signal averaged ECG and chemoreflexsensitivity in paroxysmal atrial fibrillation

Electrophysiologic and electroanatomic changes in the human atrium associated with age

Low Atrial Fibrillatory Rate Is Associated With Poor Outcome in Patients With Mild to Moderate Heart Failure

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