Influence of age on operative mortality and long‐term survival after lung resection for bronchogenic carcinoma

Abstract

Influence of age on operative mortality and long-term survival after lung resection for bronchogenic carcinoma. M. de Perrot, M. Licker, M.A. Reymond, J. Robert, A. Spiliopoulos. #ERS Journals Ltd 1999. ABSTRACT: The proportion of elderly patients presenting with bronchogenic carcinoma is increasing. To study the impact of age on clinical presentation, management and outcome of patients, the authors have reviewed their clinical experience over the last 20 yrs.Between 1977 and 1996, 1,079 patients underwent thoracotomy for primary lung carcinoma in the authors' institution. Patients were grouped by age at the time of surgery as <60 yrs, 60±69 yrs and $70 yrs.Although the mode of clinical presentation was similar between all age groups, patients <60 yrs were more prone to have advanced stage carcinoma at the time of diagnosis. The rates of exploratory thoracotomy and pneumonectomy were higher in patients <70 yrs, whereas lobectomies and lesser resections largely predominated in patients $70 yrs. The mortality rate following lobectomy and lesser resection increased from 1.3% in patients <60 yrs to 5.5% in patients $60 yrs (p=0.04) and the mortality rate following pneumonectomy increased from 6.5% in patients <60 yrs to 13.7% in patients $70 yrs (p=0.24). The specific long-term survival, which included only the patients who died from primary lung carcinoma, was similar in all age groups.Operative mortality and survival rates are acceptable in patients $70 yrs. Therefore, age in itself should not constitute a contraindication to surgical lung resection for primary lung carcinoma as long as a careful preoperative assessment is performed to appropriately select surgical candidates.

Management and outcome of patients undergoing thoracic surgery in a regional chest medical centre

“…Concerning lung cancer data, our perioperative mortality rate (2.6%) compares favourably with published data ( Table 5) and was slightly lower than operative mortality achieved by the same team of surgeons and anaesthesiologists at the University Hospital of Geneva (4.0%) [10]. The preoperative selection process probably accounted for these differences as higher risk patients were not accepted in Montana and were preferably admitted to the University Hospital.…”

Is it safe to include octogenarians at the start of a video-assisted thoracic surgery lobectomy programme?

“…In those offered surgery, 5-year survival rates were comparable (63.2%, 58.4% and 61.4%, respectively). For patients 80 years or older who received single-modality, less than lobectomy surgery, the outcome was statistically inferior [12,17,18].…”

Definition of stereotactic body radiotherapy

“…Perioperative morbidity is associated with older age (> 70 years) and the presence of comorbidities [38, 39]. Therefore, pulmonary function tests, as well as cardiac and performance status assessment are recommended before estimating the operative risk.…”