Influence of Age on Retinal and Optic Nerve Head Blood Circulation

Groh, Michael J. M.; Michelson, Georg; Langhans, Marcus J.; Harazny, Joanna

doi:10.1016/s0161-6420(96)30662-3

Cited by 90 publications

(56 citation statements)

References 17 publications

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“…In addition to the cell density decreases, blood supply to the eye is reduced with age [32]. More specifically, it has been reported that retinal (6-11% per decade) [22,46] and choroidal [14,32] blood flow and the number of functioning choroidal arterioles [26] decrease in parallel with age. Increases in the diameter of the capillary-free zone [31] and some atrophy or occlusion of macular capillaries have also been reported [7,52].…”

Section: Discussionmentioning

confidence: 99%

Senescence of human multifocal electroretinogram components: a localized approach

Tzekov

Gerth

Werner

2004

Graefe's Arch Clin Exp Ophthalmol

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Background-Previous studies have shown significant age-related changes in the first-order kernel of multifocal ERG (mfERG) responses. All of these reports were based upon ring averages across the retinal field. This study was carried out to determine age-related changes in the localized response and localized variability in the mfERG parameters: N1P1 amplitude, scalar product and implicit time of P1.

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Section: Discussionmentioning

confidence: 99%

Senescence of human multifocal electroretinogram components: a localized approach

Tzekov

Gerth

Werner

2004

Graefe's Arch Clin Exp Ophthalmol

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“…Studies have shown that age and gender induce a decline in retrobulbar [1][2][3], choroidal [4,5] and retinal [6,7] blood flow. Further investigations have shown that hormones are also a factor in retrobulbar [8] and choroidal [9,10] circulation.…”

Section: Introductionmentioning

confidence: 99%

Gender and Age Effects on Pulsatile Ocular Blood Flow

et al. 2003

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Purpose: To examine gender and age effects on pulsatile ocular blood flow (POBF). Methods: Normal subjects, 152 females and 107 males, were separated into younger (40–50) and older (50–60) age groups. Results: For younger women, mean POBF (15.3 ± 3.7 µl/s) was significantly different (p < 0.01) than for older women (13.8 ± 3.5 µl/s), younger men (13.2 ± 3.3 µl/s), and older men (13.3 ± 3.1 µl/s). The mean POBFs for each of the latter three groups were not significantly different (p > 0.41) from one another. The four groups showed no significant differences in intraocular pressure (p > 0.07) or refraction (p > 0.46). Pulse rate for younger women was significantly higher (p < 0.05) than for the older two groups, but there were no significant pulse rate differences (p > 0.08) between other groups. POBF was not correlated with IOP (r² < 0.04), refraction (r² < 0.009) or pulse rate (r² < 0.04). Conclusion: Gender and age play an important role in POBF.

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“…In healthy individuals, CDI showed a decrease in blood flow parameters in both the ophthalmic and central retinal arteries correlating with increasing age (Williamson, 1995) (Lam, 2003). The resistance index of the vessels seems to increase with age, as a possible sign of increased arterial stiffness (Groh, 1996). Different devices have also identified choroidal and optic nerve head blood flow decreases (Ravalico, 1996) (Boehm, 2005).…”

Section: A Sick Eye In a Sick Bodymentioning

confidence: 99%