Influence of age on the correlations of hematological and biochemical variables with the stability of erythrocyte membrane in relation to sodium dodecyl sulfate

Freitas, Mariana Vaini de; Márquez-Bernardes, Liandra Freitas; Arvelos, Letícia Ramos de; Paraíso, Lara Ferreira; Oliveira, Ana Flávia M. Gonçalves e; Netto, Rita de Cássia Mascarenhas; Neto, Morun Bernardino; Garrote-Filho, Mário da Silva; Souza, Paulo César A. de; Penha-Silva, Nilson

doi:10.1179/1607845413y.0000000145

Cited by 21 publications

(36 citation statements)

References 42 publications

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“…Wider patient series with longer follow-up periods are needed to increase the reliability of RDW results. In recent studies, it was reported that there was a positive correlation between age and RDW (14,15). Although age was not taken into account in our study, no significant differences were identified between groups in terms of age.…”

Section: Discussioncontrasting

confidence: 50%

What is the effect of treatment modality on red blood cell distribution width in patients with acute cholecystitis?

Yazici¹,

Demir²,

Bozdağ³

et al. 2015

UCD

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Objective:The red blood cell distribution width (RDW) has recently been used as a marker to predict outcome in various patient groups. In this study, we aimed to examine how RDW is influenced during the treatment and followup of cases of acute cholecystitis which is a common inflammatory disease.Material and Methods: Seventy-two patients who were treated for acute cholecystitis, were included into the study. The demographic data, leukocyte count, RDW, C-reactive protein (CRP) values and treatment protocols of these patients were prospectively recorded. The patients who received medical treatment for acute cholecystitis (Group A, n=33) and those who underwent surgery (Group B, n=39) were examined in separate groups.Results: There were 27 male and 45 female patients with a mean age of 50.1±18 years (min-max: 21-94). In Group B, 33 patients underwent laparoscopic cholecystectomy, whereas 6 patients underwent open cholecystectomy. The RDW values on admission were not significantly different between two groups. However the post-treatment/predischarge RDW values were significantly lower in the surgical group (14.4±1.9 to 13.6±1.1, respectively, p<0.05). Also, no significant RDW change was identified in the medical treatment group based on an intra-group assessment, whereas a significant decrease was observed in Group B (on admission and following surgical treatment: 14.3±1.3, 13.6±1.1, respectively, p=0.015). No significant differences were observed between groups in terms of CRP and leucocyte values. Conclusion:There was a significant decrease in RDW values in patients who were treated with surgery for acute cholecystitis, while this response could not be observed with medical treatment.

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Section: Discussioncontrasting

confidence: 50%

What is the effect of treatment modality on red blood cell distribution width in patients with acute cholecystitis?

Yazici¹,

Demir²,

Bozdağ³

et al. 2015

UCD

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“…À medida que a concentração salina no meio diminui, há um aumento gradativo da lise eritrocitária, que a partir de um determinado ponto sofre uma aceleração exponencial. Ao atingir o ponto intermediário da curva, a liberação de hemoglobina sofre uma desaceleração hiperbólica, até atingir um platô máximo estável (representado pela sigla A max ), que se refere ao valor estacionário máximo de absorvância de Freitas et al, 2014).…”

Section: Propriedades Da Membrana Eritrocitáriaunclassified

“…In this study, the possible association of alterations in erythrocyte behavior with PE will be investigated through the analysis of osmotic stability. The analysis of the erythrocyte behavior in an hyposmotic gradient is a powerful method that reflects the deformability [28], stability [29,30] and the membrane composition of these cells, allowing the investigation of the influences of the lipid blood levels [31] oxidative aggression [26], among other factors.…”

Section: Considerações Finaismentioning

confidence: 99%

“…In this work, the osmotic stability of erythrocytes was evaluated by statistical treatment of the hyposmotic gradient lysis curve, using variables and indices that have been very useful in the evaluation of several other physiologic or pathologic conditions [29,33] Faced with the need to better understand the differences between EOPE and LOPE, this study compared anthropometric, hemodynamic, biochemical, hematologic and osmotic stability profiles of red blood cells between these two types of PE.…”

Section: Considerações Finaismentioning

confidence: 99%

“…In addition, the erythrocyte membrane has a high content of phospholipids composed of polyunsaturated fatty acids, which makes it very susceptible to lipoperoxidation (Abad et al, 2010). The content of unsaturated fatty acids (of their phospholipids) in relation to the membrane cholesterol content is essential for maintaining the fluidity, deformability and stability of erythrocytes de Freitas et al, 2014). Lipoperoxidation alters this proportion of lipids and impairs the fluidity, deformability and stability of erythrocytes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alterações antropométricas, hemodinâmicas, hematológicas e bioquímicas na pré-eclâmpsia

Freitas¹

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Influence of Plasmodium vivax malaria on the relations between the osmotic stability of human erythrocyte membrane and hematological and biochemical variables

et al. 2013

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This study evaluated the influence of infection by Plasmodium vivax on the relations between hematological and biochemical variables and the osmotic stability of the erythrocyte membrane in a Brazilian Amazon population. A total of 72 patients with P. vivax malaria were included in the study and invited to return after 14 days, post-treatment with chloroquine and primaquine, for clinical and laboratorial reevaluations. The osmotic stability of the erythrocyte membrane was analyzed by nonlinear regression of the dependency of the absorbance of hemoglobin, released with hemolysis, as a function of the salt concentration, and it was represented by the inverse of the salt concentration at the midpoint of the curve (1/H 50) and by the variation of salt concentration, which promotes lysis (dX). Bivariate and multivariate methods were used in the analysis of the results. Prior to treatment of the disease, the erythrocytes showed greater stability, probably due to the natural selection of young and also more stable erythrocytes. The bivariate analysis showed that 1/H 50 was positively correlated with red cell distribution width (RDW), urea, triglycerides, and very low-density lipoprotein (VLDL)-cholesterol, but negatively associated with albumin, HDL-cholesterol, and indirect bilirubin, while dX was negatively associated with the mean corpuscular hemoglobin concentration. These associations were confirmed by canonical correlation analysis. Stepwise multiple linear regression showed that albumin, urea, triglycerides, and VLDL-cholesterol are the variables with the highest abilities of predicting erythrocyte stability. The bivariate analysis also showed that the hematological index RDW was related to elevated levels of bilirubin and decreased levels of albumin and urea, associated with liver damage resulting from malaria.

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Influence of age on the correlations of hematological and biochemical variables with the stability of erythrocyte membrane in relation to sodium dodecyl sulfate

Abstract: The positive association between erythrocyte stability and RDW may reflect one possible mechanism involved in the clinical meaning of this hematological index.

Cited by 21 publications

References 42 publications

What is the effect of treatment modality on red blood cell distribution width in patients with acute cholecystitis?

What is the effect of treatment modality on red blood cell distribution width in patients with acute cholecystitis?

Alterações antropométricas, hemodinâmicas, hematológicas e bioquímicas na pré-eclâmpsia

Influence of Plasmodium vivax malaria on the relations between the osmotic stability of human erythrocyte membrane and hematological and biochemical variables

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