Influence of ageing on IgE‐mediated reactions in allergic patients

Hanneuse, Yvette; Delespesse, Guy; Hudson, D.G.; Halleux, F. de; Jacques, Julien

doi:10.1111/j.1365-2222.1978.tb00461.x

Cited by 58 publications

(20 citation statements)

References 7 publications

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“…No direct correlation between age and reactivity was observed. Workers like Kuhr et al (1990) and Hanneuse et al (1978) reported similar results. Although some patients with positive family history to allergic complaints reacted more, the difference in reactivity with the other group was not significant.…”

Section: Discussionsupporting

confidence: 88%

Studies on the allergenicity of nine tropical pollen allergens

Prakashkumar

Mathew

Ravindran

1998

Grana

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Section: Discussionsupporting

confidence: 88%

Studies on the allergenicity of nine tropical pollen allergens

Prakashkumar

Mathew

Ravindran

1998

Grana

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“…In addition, Hanneuse et al reported a declining trend with age in total serum IgE, circulating eosinophils, mean positive number of RAST as well as mean positive value of RAST to individual allergens that is more pronounced in atopic females than males. [47] Clinically, however, they noted a disconnect with a decreased corticosteroid requirement in younger atopic patients than older patients despite an increased prevalence in markers of atopy in the younger cohort. Raherison and colleagues found a strong relationship between percent positive RAST scores (40-42% in Asthma and/or allergic rhinitis versus 7% in healthy) and clinical symptoms of allergic rhinitis and asthma in elderly patients.…”

Section: Clinical Implications Of Atopy On Agingmentioning

confidence: 99%

Role of Allergen Sensitization in Older Adults

Viswanathan

Mathur

2011

Curr Allergy Asthma Rep

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There is a common perception among physicians and patients that allergic diseases are not relevant in older adults. There is recognition that both innate and adaptive immune functions decline with aging. It is the function of a variety of immune cells in the form of allergic inflammation that is a hallmark of allergic diseases. In fact, there is a fairly consistent observation that measures of allergic sensitization, such as skin prick testing, specific IgE or total IgE decline with age. Nonetheless, the association between allergic sensitization and allergic diseases, particularly asthma and allergic rhinitis, remains robust in the elderly population. Consequently, an appropriate evaluation of allergic sensitivities is warranted and indicated in older asthma and rhinitis patients in order to provide optimal care for the individual and minimize any resultant morbidity and mortality.

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“…Concerning allergic diseases, the incidence of onset of allergic symptoms, as well as their severity seems to decrease with age [1]. Atopy is a relatively common, adverse humoral immune system response to common environmental agents (allergens) involving the production of allergen-specific IgE.…”

Section: Introductionmentioning

confidence: 99%

Total and specific serum IgE decreases with age in patients with allergic rhinitis, asthma and insect allergy but not in patients with atopic dermatitis

Mediaty

Neuber

2005

Immun Ageing

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Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total and specific IgE. Atopic disorders are complex diseases that involve interactions among several physiological systems, e.g. skin, lung, mucosae, and the immune system. It was the aim of this study to compare the effects of age on total and specific IgE in patients with atopic dermatitis (AD), allergic rhinitis or asthma, and insect allergy, respectively.The study population consisted of 559 individuals (male: 229 and female: 330). Total and allergen specific IgE was measured in every individual. From the whole study population, 113 patients suffered from atopic dermatitis (AD), 132 had allergic rhinitis or asthma, and 314 were tested because of insect allergy. Total and specific serum IgE was significantly decreased as a function of age in patients with allergic rhinitis and asthma and with insect allergy. In contrast, no significant decrease of total and specific serum IgE in old individuals with AD was observed. Additionally, in the group of patients with a total IgE < 300 kU/l a reduction of total serum IgE was significantly correlated with age. In contrast, patients with IgE levels > 300 kU/l showed no correlation with age.

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Influence of ageing on IgE‐mediated reactions in allergic patients

Cited by 58 publications

References 7 publications

Studies on the allergenicity of nine tropical pollen allergens

Studies on the allergenicity of nine tropical pollen allergens

Role of Allergen Sensitization in Older Adults

Total and specific serum IgE decreases with age in patients with allergic rhinitis, asthma and insect allergy but not in patients with atopic dermatitis

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